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PDBsum entry 2he3

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protein metals links
Oxidoreductase PDB id
2he3
Jmol
Contents
Protein chain
185 a.a. *
Metals
_CL ×2
Waters ×135
* Residue conservation analysis
PDB id:
2he3
Name: Oxidoreductase
Title: Crystal structure of the selenocysteine to cysteine mutant o glutathionine peroxidase 2 (gpx2)
Structure: Glutathione peroxidase 2. Chain: a. Synonym: gshpx-2, gpx-2, glutathione peroxidase-gastrointes gshpx-gi, glutathione peroxidase- related protein 2, gastro glutathione peroxidase, gprp. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Tetramer (from PDB file)
Resolution:
2.10Å     R-factor:   0.158     R-free:   0.205
Authors: C.Johansson,K.L.Kavanagh,A.Rojkova,O.Gileadi,F.Von Delft, C.Arrowsmith,J.Weigelt,M.Sundstrom,A.Edwards,U.Oppermann,St Genomics Consortium (Sgc)
Key ref: K.L.Kavanagh and u.oppermann Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (gpx2). To be published, .
Date:
21-Jun-06     Release date:   25-Jul-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18283  (GPX2_HUMAN) -  Glutathione peroxidase 2
Seq:
Struc:
190 a.a.
185 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.11.1.9  - Glutathione peroxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
2 × glutathione
+ H(2)O(2)
= glutathione disulfide
+ 2 × H(2)O
      Cofactor: Se(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   3 terms 
  Biological process     oxidation-reduction process   6 terms 
  Biochemical function     electron carrier activity     4 terms