PDBsum entry 2hck

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protein ligands metals Protein-protein interface(s) links
Transferase PDB id
Protein chains
438 a.a. *
QUE ×2
_CA ×2
Waters ×4
* Residue conservation analysis
PDB id:
Name: Transferase
Title: Src family kinase hck-quercetin complex
Structure: Hematopoetic cell kinase hck. Chain: a, b. Fragment: sh3-sh2-kinase-regulatory tail. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Gene: human hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Biol. unit: Monomer (from PDB file)
3.00Å     R-factor:   0.228     R-free:   0.311
Authors: F.Sicheri,I.Moarefi,J.Kuriyan
Key ref: F.Sicheri et al. (1997). Crystal structure of the Src family tyrosine kinase Hck. Nature, 385, 602-609. PubMed id: 9024658
25-Feb-97     Release date:   20-Aug-97    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
P08631  (HCK_HUMAN) -  Tyrosine-protein kinase HCK
526 a.a.
438 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.  - Non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
+ [protein]-L-tyrosine
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     4 terms  


Nature 385:602-609 (1997)
PubMed id: 9024658  
Crystal structure of the Src family tyrosine kinase Hck.
F.Sicheri, I.Moarefi, J.Kuriyan.
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

Literature references that cite this PDB file's key reference

  PubMed id Reference
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Retroviral oncogenes: a historical primer.
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Crystal structure of inhibitor of κB kinase β.
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PDB codes: 3qa8 3qad 3rzf
21509657 H.Liang, T.Liu, F.Chen, Z.Liu, and S.Liu (2011).
A full-length 3D structure for MAPK/ERK kinase 2 (MEK2).
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21365684 J.Jung, I.J.Byeon, J.Ahn, and A.M.Gronenborn (2011).
Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.
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21359199 L.P.O'Reilly, S.C.Watkins, and T.E.Smithgall (2011).
An unexpected role for the clock protein timeless in developmental apoptosis.
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21474065 N.Jura, X.Zhang, N.F.Endres, M.A.Seeliger, T.Schindler, and J.Kuriyan (2011).
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
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21385611 R.Kristelly, T.W.Qiu, N.J.Gunn, D.B.Scanlon, and T.D.Mulhern (2011).
Bacterial expression and purification of active hematopoietic cell kinase.
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20925106 R.W.McLachlan, and A.S.Yap (2011).
Protein tyrosine phosphatase activity is necessary for E-cadherin-activated Src signaling.
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22101434 S.K.Yoo, T.W.Starnes, Q.Deng, and A.Huttenlocher (2011).
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.
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20585391 A.Dusa, C.Mouton, C.Pecquet, M.Herman, and S.N.Constantinescu (2010).
JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors.
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Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.
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20585582 K.F.Ahmad, and W.A.Lim (2010).
The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin.
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PDB code: 3jv3
20336692 M.Rabiller, M.Getlik, S.Klüter, A.Richters, S.Tückmantel, J.R.Simard, and D.Rauh (2010).
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Structural biology: Proteins in dynamic equilibrium.
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20584982 P.Patwardhan, and M.D.Resh (2010).
Myristoylation and membrane binding regulate c-Src stability and kinase activity.
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Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
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PDB codes: 3lj0 3lj1 3lj2
20421461 S.S.Taylor, and A.P.Kornev (2010).
Yet another "active" pseudokinase, Erb3.
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20798061 S.Yang, L.Blachowicz, L.Makowski, and B.Roux (2010).
Multidomain assembled states of Hck tyrosine kinase in solution.
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20685133 T.Gheyi, L.Rodgers, R.Romero, J.M.Sauder, and S.K.Burley (2010).
Mass spectrometry guided in situ proteolysis to obtain crystals for X-ray structure determination.
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Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
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PDB code: 3orm
20670214 X.Shi, S.Opi, A.Lugari, A.Restouin, T.Coursindel, I.Parrot, J.Perez, E.Madore, P.Zimmermann, J.Corbeil, M.Huang, S.T.Arold, Y.Collette, and X.Morelli (2010).
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20209159 Y.H.Hsu, and J.A.Traugh (2010).
Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysis.
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18827185 A.Quintás-Cardama, and J.Cortes (2009).
Molecular biology of bcr-abl1-positive chronic myeloid leukemia.
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19712106 A.Stein, R.A.Pache, P.Bernadó, M.Pons, and P.Aloy (2009).
Dynamic interactions of proteins in complex networks: a more structured view.
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19290920 B.B.Au-Yeung, S.Deindl, L.Y.Hsu, E.H.Palacios, S.E.Levin, J.Kuriyan, and A.Weiss (2009).
The structure, regulation, and function of ZAP-70.
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19805512 C.Brignatz, M.P.Paronetto, S.Opi, M.Cappellari, S.Audebert, V.Feuillet, G.Bismuth, S.Roche, S.T.Arold, C.Sette, and Y.Collette (2009).
Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.
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19743411 G.Yang, Q.Li, S.Ren, X.Lu, L.Fang, W.Zhou, F.Zhang, F.Xu, Z.Zhang, R.Zeng, F.Lottspeich, and Z.Chen (2009).
Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins.
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19124027 I.Westwood, D.M.Cheary, J.E.Baxter, M.W.Richards, R.L.van Montfort, A.M.Fry, and R.Bayliss (2009).
Insights into the conformational variability and regulation of human Nek2 kinase.
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PDB codes: 2w5a 2w5b 2w5h
19833732 J.Zhao, Y.Zhang, S.S.Ithychanda, Y.Tu, K.Chen, J.Qin, and C.Wu (2009).
Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling.
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19288491 K.F.Chan, Y.Zhao, T.W.Chow, C.S.Yan, D.L.Ma, B.A.Burkett, I.L.Wong, L.M.Chow, and T.H.Chan (2009).
Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.
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19244618 K.Huang, Y.H.Wang, A.Brown, and G.Sun (2009).
Identification of N-terminal lobe motifs that determine the kinase activity of the catalytic domains and regulatory strategies of Src and Csk protein tyrosine kinases.
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19787002 L.C.Kim, L.Song, and E.B.Haura (2009).
Src kinases as therapeutic targets for cancer.
  Nat Rev Clin Oncol, 6, 587-595.  
19825829 M.A.Meyn, and T.E.Smithgall (2009).
Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.
  Sci Signal, 2, ra64.  
19276351 M.A.Seeliger, P.Ranjitkar, C.Kasap, Y.Shan, D.E.Shaw, N.P.Shah, J.Kuriyan, and D.J.Maly (2009).
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations.
  Cancer Res, 69, 2384-2392.
PDB codes: 3g6g 3g6h
19776125 M.J.Wagner, and J.R.Smiley (2009).
Herpes simplex virus requires VP11/12 to induce phosphorylation of the activation loop tyrosine (Y394) of the Src family kinase Lck in T lymphocytes.
  J Virol, 83, 12452-12461.  
19489734 M.K.Tarrant, and P.A.Cole (2009).
The chemical biology of protein phosphorylation.
  Annu Rev Biochem, 78, 797-825.  
18815812 M.P.Kim, S.I.Park, S.Kopetz, and G.E.Gallick (2009).
Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis.
  Cell Tissue Res, 335, 249-259.  
19015244 M.Tanaka, K.Sasaki, R.Kamata, Y.Hoshino, K.Yanagihara, and R.Sakai (2009).
A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.
  Mol Cell Biol, 29, 402-413.  
19620276 N.Basu, R.Bhandari, V.T.Natarajan, and S.S.Visweswariah (2009).
Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis.
  Mol Cell Biol, 29, 5277-5289.  
19563760 N.Jura, N.F.Endres, K.Engel, S.Deindl, R.Das, M.H.Lamers, D.E.Wemmer, X.Zhang, and J.Kuriyan (2009).
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
  Cell, 137, 1293-1307.
PDB code: 3gt8
20007378 N.Jura, Y.Shan, X.Cao, D.E.Shaw, and J.Kuriyan (2009).
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
  Proc Natl Acad Sci U S A, 106, 21608-21613.
PDB code: 3kex
18623061 N.K.Banavali, and B.Roux (2009).
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases.
  Proteins, 74, 378-389.  
19888460 N.M.Levinson, P.R.Visperas, and J.Kuriyan (2009).
The tyrosine kinase Csk dimerizes through Its SH3 domain.
  PLoS One, 4, e7683.  
19920076 N.Yokoyama, and C.C.Malbon (2009).
Dishevelled-2 docks and activates Src in a Wnt-dependent manner.
  J Cell Sci, 122, 4439-4451.  
19926274 P.Filippakopoulos, S.Müller, and S.Knapp (2009).
SH2 domains: modulators of nonreceptor tyrosine kinase activity.
  Curr Opin Struct Biol, 19, 643-649.  
19168626 P.J.Mintz, M.Cardó-Vila, M.G.Ozawa, A.Hajitou, R.Rangel, L.Guzman-Rojas, D.R.Christianson, M.A.Arap, R.J.Giordano, G.R.Souza, J.Easley, A.Salameh, S.Oliviero, R.R.Brentani, E.Koivunen, W.Arap, and R.Pasqualini (2009).
An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.
  Proc Natl Acad Sci U S A, 106, 2182-2187.  
19717557 Q.Qi, and A.August (2009).
The Tec family kinase Itk exists as a folded monomer in vivo.
  J Biol Chem, 284, 29882-29892.  
19150426 R.Barouch-Bentov, J.Che, C.C.Lee, Y.Yang, A.Herman, Y.Jia, A.Velentza, J.Watson, L.Sternberg, S.Kim, N.Ziaee, A.Miller, C.Jackson, M.Fujimoto, M.Young, S.Batalov, Y.Liu, M.Warmuth, T.Wiltshire, M.P.Cooke, and K.Sauer (2009).
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.
  Mol Cell, 33, 43-52.  
19164531 R.E.Iacob, T.Pene-Dumitrescu, J.Zhang, N.S.Gray, T.E.Smithgall, and J.R.Engen (2009).
Conformational disturbance in Abl kinase upon mutation and deregulation.
  Proc Natl Acad Sci U S A, 106, 1386-1391.  
19296652 R.E.Wang, J.L.Kao, C.A.Hilliard, R.K.Pandita, J.L.Roti Roti, C.R.Hunt, and J.S.Taylor (2009).
Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives.
  J Med Chem, 52, 1912-1921.  
19920178 S.Deindl, T.A.Kadlecek, X.Cao, J.Kuriyan, and A.Weiss (2009).
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
  Proc Natl Acad Sci U S A, 106, 20699-20704.  
19225111 S.Yang, N.K.Banavali, and B.Roux (2009).
Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories.
  Proc Natl Acad Sci U S A, 106, 3776-3781.  
19290925 T.Kurosaki, and M.Hikida (2009).
Tyrosine kinases and their substrates in B lymphocytes.
  Immunol Rev, 228, 132-148.  
19909371 Y.Kulathu, G.Grothe, and M.Reth (2009).
Autoinhibition and adapter function of Syk.
  Immunol Rev, 232, 286-299.  
19109437 Y.Shan, M.A.Seeliger, M.P.Eastwood, F.Frank, H.Xu, M...Jensen, R.O.Dror, J.Kuriyan, and D.E.Shaw (2009).
A conserved protonation-dependent switch controls drug binding in the Abl kinase.
  Proc Natl Acad Sci U S A, 106, 139-144.  
19930468 Z.Honda, T.Suzuki, and H.Honda (2009).
Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction.
  Genes Cells, 14, 1383-1394.  
18283487 Z.Li, and Z.Xie (2009).
The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades.
  Pflugers Arch, 457, 635-644.  
18239682 A.C.Pike, P.Rellos, F.H.Niesen, A.Turnbull, A.W.Oliver, S.A.Parker, B.E.Turk, L.H.Pearl, and S.Knapp (2008).
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
  EMBO J, 27, 704-714.
PDB codes: 2j51 2j7t 2j90 2jfl 2jfm 2uv2
18155170 D.E.Johnson (2008).
Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis.
  Adv Enzyme Regul, 48, 98.  
18660530 D.Filipp, B.Moemeni, A.Ferzoco, K.Kathirkamathamby, J.Zhang, O.Ballek, D.Davidson, A.Veillette, and M.Julius (2008).
Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts.
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18268019 F.Liang, Y.Luo, Y.Dong, C.D.Walls, J.Liang, H.Y.Jiang, J.R.Sanford, R.C.Wek, and Z.Y.Zhang (2008).
Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase.
  J Biol Chem, 283, 10339-10346.  
19035848 I.Dufau, A.Lazzari, A.Samson, I.Pouny, and F.Ausseil (2008).
Optimization of a homogeneous assay for kinase inhibitors in plant extracts.
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18411193 I.G.Muñoz, F.J.Blanco, and G.Montoya (2008).
On the relevance of defining protein structures in cancer research.
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18841497 K.Kundrapu, L.Colenberg, and R.J.Duhé (2008).
Activation loop tyrosines allow the JAK2(V617F) mutant to attain hyperactivation.
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18421779 L.Pirola, and S.Fröjdö (2008).
Resveratrol: one molecule, many targets.
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18768392 L.Trentin, M.Frasson, A.Donella-Deana, F.Frezzato, M.A.Pagano, E.Tibaldi, C.Gattazzo, R.Zambello, G.Semenzato, and A.M.Brunati (2008).
Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia.
  Blood, 112, 4665-4674.  
18794843 M.Azam, M.A.Seeliger, N.S.Gray, J.Kuriyan, and G.Q.Daley (2008).
Activation of tyrosine kinases by mutation of the gatekeeper threonine.
  Nat Struct Mol Biol, 15, 1109-1118.
PDB codes: 3dqw 3dqx
17910071 M.D.Jacobs, P.R.Caron, and B.J.Hare (2008).
Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: structure of lck/imatinib complex.
  Proteins, 70, 1451-1460.
PDB code: 2pl0
18480048 M.L.Chu, L.M.Chavas, K.T.Douglas, P.A.Eyers, and L.Tabernero (2008).
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
  J Biol Chem, 283, 21495-21500.
PDB codes: 2zmc 2zmd
18775312 P.Filippakopoulos, M.Kofler, O.Hantschel, G.D.Gish, F.Grebien, E.Salah, P.Neudecker, L.E.Kay, B.E.Turk, G.Superti-Furga, T.Pawson, and S.Knapp (2008).
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
  Cell, 134, 793-803.
PDB codes: 3bkb 3cbl 3cd3
18727838 R.Mosca, B.Brannetti, and T.R.Schneider (2008).
Alignment of protein structures in the presence of domain motions.
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18452309 S.Chen, T.P.Dumitrescu, T.E.Smithgall, and J.R.Engen (2008).
Abl N-terminal cap stabilization of SH3 domain dynamics.
  Biochemistry, 47, 5795-5803.  
18541536 S.Granum, T.C.Andersen, M.Sørlie, M.Jørgensen, L.Koll, T.Berge, T.Lea, B.Fleckenstein, A.Spurkland, and V.Sundvold-Gjerstad (2008).
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
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18369437 S.Yang, and B.Roux (2008).
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
  PLoS Comput Biol, 4, e1000047.  
18842137 T.Lenaerts, J.Ferkinghoff-Borg, F.Stricher, L.Serrano, J.W.Schymkowitz, and F.Rousseau (2008).
Quantifying information transfer by protein domains: analysis of the Fyn SH2 domain structure.
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18177487 T.Senga, H.Hasegawa, M.Tanaka, M.A.Rahman, S.Ito, and M.Hamaguchi (2008).
The cysteine-cluster motif of c-Src: its role for the heavy metal-mediated activation of kinase.
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18390552 W.Li, S.L.Young, N.King, and W.T.Miller (2008).
Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation.
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18433075 Z.P.Xiao, H.Q.Li, L.Shi, P.C.Lv, Z.C.Song, and H.L.Zhu (2008).
Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones.
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17530729 A.Kumar, Y.Wang, X.Lin, G.Sun, and K.Parang (2007).
Synthesis and Evaluation of 3-Phenylpyrazolo[3,4-d]pyrimidine-Peptide Conjugates as Src Kinase Inhibitors.
  ChemMedChem, 2, 1346-1360.  
17349580 C.H.Yun, T.J.Boggon, Y.Li, M.S.Woo, H.Greulich, M.Meyerson, and M.J.Eck (2007).
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.
  Cancer Cell, 11, 217-227.
PDB codes: 2itn 2ito 2itp 2itq 2itt 2itu 2itv 2itw 2itx 2ity 2itz 2j6m
17192274 F.Liang, J.Liang, W.Q.Wang, J.P.Sun, E.Udho, and Z.Y.Zhang (2007).
PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation.
  J Biol Chem, 282, 5413-5419.  
17699616 J.D.Faraldo-Gómez, and B.Roux (2007).
On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
  Proc Natl Acad Sci U S A, 104, 13643-13648.  
18075577 J.Kuriyan, and D.Eisenberg (2007).
The origin of protein interactions and allostery in colocalization.
  Nature, 450, 983-990.  
17525997 J.P.Camiña, M.Lodeiro, O.Ischenko, A.C.Martini, and F.F.Casanueva (2007).
Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and beta-arrestins.
  J Cell Physiol, 213, 187-200.  
17698806 J.R.Gledhill, M.G.Montgomery, A.G.Leslie, and J.E.Walker (2007).
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols.
  Proc Natl Acad Sci U S A, 104, 13632-13637.
PDB codes: 2jiz 2jj1 2jj2
17897955 K.Nika, L.Tautz, Y.Arimura, T.Vang, S.Williams, and T.Mustelin (2007).
A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.
  J Biol Chem, 282, 36000-36009.  
17355866 M.A.Seeliger, B.Nagar, F.Frank, X.Cao, M.N.Henderson, and J.Kuriyan (2007).
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty.
  Structure, 15, 299-311.
PDB code: 2oiq
17976643 N.Bhattacharya, M.Yi, H.X.Zhou, and T.M.Logan (2007).
Backbone dynamics in an intramolecular prolylpeptide-SH3 complex from the diphtheria toxin repressor, DtxR.
  J Mol Biol, 374, 977-992.  
17380483 N.K.Banavali, and B.Roux (2007).
Anatomy of a structural pathway for activation of the catalytic domain of Src kinase Hck.
  Proteins, 67, 1096-1112.  
17652306 Q.Qi, and A.August (2007).
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
  Sci STKE, 2007, pe39.  
17327393 S.Chen, S.Brier, T.E.Smithgall, and J.R.Engen (2007).
The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.
  Protein Sci, 16, 572-581.  
17512407 S.Deindl, T.A.Kadlecek, T.Brdicka, X.Cao, A.Weiss, and J.Kuriyan (2007).
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
  Cell, 129, 735-746.
PDB code: 2ozo
17719722 S.S.Yadav, and W.T.Miller (2007).
Cooperative activation of Src family kinases by SH3 and SH2 ligands.
  Cancer Lett, 257, 116-123.  
17574014 T.A.Leonard, and J.H.Hurley (2007).
Two kinase family dramas.
  Cell, 129, 1037-1038.  
17583354 T.Furukawa, and J.Kurokawa (2007).
Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: implication for the gender difference in cardiac arrhythmias.
  Pharmacol Ther, 115, 106-115.  
17671637 T.Hunter (2007).
Treatment for chronic myelogenous leukemia: the long road to imatinib.
  J Clin Invest, 117, 2036-2043.  
17322911 T.Pawson, and N.Warner (2007).
Oncogenic re-wiring of cellular signaling pathways.
  Oncogene, 26, 1268-1275.  
18056643 X.Yu, J.P.Sun, Y.He, X.Guo, S.Liu, B.Zhou, A.Hudmon, and Z.Y.Zhang (2007).
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
  Proc Natl Acad Sci U S A, 104, 19767-19772.  
17674392 Y.Ahmadibeni, M.Hanley, M.White, M.Ayrapetov, X.Lin, G.Sun, and K.Parang (2007).
Metal-binding properties of a dicysteine-containing motif in protein tyrosine kinases.
  Chembiochem, 8, 1592-1605.  
17937769 Y.Pazos, C.J.Alvarez, J.P.Camiña, and F.F.Casanueva (2007).
Lysophosphatidic acid inhibits ghrelin secretion in the human gastric adenocarcinoma AGS cell line: role of mitogenic activated protein kinase signaling pathway.
  FEBS J, 274, 5714-5726.  
16722659 A.Kumar, G.Ye, Y.Wang, X.Lin, G.Sun, and K.Parang (2006).
Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibitors.
  J Med Chem, 49, 3395-3401.  
16543148 B.Nagar, O.Hantschel, M.Seeliger, J.M.Davies, W.I.Weis, G.Superti-Furga, and J.Kuriyan (2006).
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
  Mol Cell, 21, 787-798.
PDB code: 2fo0
16829979 B.T.Seet, I.Dikic, M.M.Zhou, and T.Pawson (2006).
Reading protein modifications with interaction domains.
  Nat Rev Mol Cell Biol, 7, 473-483.  
16492148 D.Dalgarno, T.Stehle, S.Narula, P.Schelling, M.R.van Schravendijk, S.Adams, L.Andrade, J.Keats, M.Ram, L.Jin, T.Grossman, I.MacNeil, C.Metcalf, W.Shakespeare, Y.Wang, T.Keenan, R.Sundaramoorthi, R.Bohacek, M.Weigele, and T.Sawyer (2006).
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
  Chem Biol Drug Des, 67, 46-57.
PDB codes: 2bdf 2bdj
16613860 D.T.Lodowski, V.M.Tesmer, J.L.Benovic, and J.J.Tesmer (2006).
The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.
  J Biol Chem, 281, 16785-16793.
PDB code: 2acx
16441665 E.Kim, S.Lee, M.F.Mian, S.U.Yun, M.Song, K.S.Yi, S.H.Ryu, and P.G.Suh (2006).
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling.
  FEBS J, 273, 793-804.  
16597828 E.Ozkirimli, and C.B.Post (2006).
Src kinase activation: A switched electrostatic network.
  Protein Sci, 15, 1051-1062.  
16245368 F.Nasertorabi, K.Tars, K.Becherer, R.Kodandapani, L.Liljas, K.Vuori, and K.R.Ely (2006).
Molecular basis for regulation of Src by the docking protein p130Cas.
  J Mol Recognit, 19, 30-38.
PDB code: 1x27
16864780 J.Inglese, D.S.Auld, A.Jadhav, R.L.Johnson, A.Simeonov, A.Yasgar, W.Zheng, and C.P.Austin (2006).
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
  Proc Natl Acad Sci U S A, 103, 11473-11478.  
16322569 J.M.Hochrein, E.C.Lerner, A.P.Schiavone, T.E.Smithgall, and J.R.Engen (2006).
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.
  Protein Sci, 15, 65-73.  
16940108 J.M.Pérez-Victoria, F.Cortés-Selva, A.Parodi-Talice, B.I.Bavchvarov, F.J.Pérez-Victoria, F.Muñoz-Martínez, M.Maitrejean, M.P.Costi, D.Barron, A.Di Pietro, S.Castanys, and F.Gamarro (2006).
Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.
  Antimicrob Agents Chemother, 50, 3102-3110.  
16754879 M.Azam, V.Nardi, W.C.Shakespeare, C.A.Metcalf, R.S.Bohacek, Y.Wang, R.Sundaramoorthi, P.Sliz, D.R.Veach, W.G.Bornmann, B.Clarkson, D.C.Dalgarno, T.K.Sawyer, and G.Q.Daley (2006).
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.
  Proc Natl Acad Sci U S A, 103, 9244-9249.  
17110931 M.Engel, V.Hindie, L.A.Lopez-Garcia, A.Stroba, F.Schaeffer, I.Adrian, J.Imig, L.Idrissova, W.Nastainczyk, S.Zeuzem, P.M.Alzari, R.W.Hartmann, A.Piiper, and R.M.Biondi (2006).
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.
  EMBO J, 25, 5469-5480.  
16790421 M.K.Ayrapetov, Y.H.Wang, X.Lin, X.Gu, K.Parang, and G.Sun (2006).
Conformational basis for SH2-Tyr(P)527 binding in Src inactivation.
  J Biol Chem, 281, 23776-23784.  
16777958 M.L.Galisteo, Y.Yang, J.Ureña, and J.Schlessinger (2006).
Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.
  Proc Natl Acad Sci U S A, 103, 9796-9801.  
16640460 N.M.Levinson, O.Kuchment, K.Shen, M.A.Young, M.Koldobskiy, M.Karplus, P.A.Cole, and J.Kuriyan (2006).
A Src-like inactive conformation in the abl tyrosine kinase domain.
  PLoS Biol, 4, e144.
PDB codes: 2g1t 2g2f 2g2h 2g2i
17079130 P.Pellicena, and J.Kuriyan (2006).
Protein-protein interactions in the allosteric regulation of protein kinases.
  Curr Opin Struct Biol, 16, 702-709.  
16756506 R.P.Bhattacharyya, A.Reményi, B.J.Yeh, and W.A.Lim (2006).
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.
  Annu Rev Biochem, 75, 655-680.  
16849330 R.P.Trible, L.Emert-Sedlak, and T.E.Smithgall (2006).
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.
  J Biol Chem, 281, 27029-27038.  
17018524 S.A.Lieser, J.Shaffer, and J.A.Adams (2006).
SRC tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase Csk.
  J Biol Chem, 281, 38004-38012.  
16425036 S.Calpe, E.Erdos, G.Liao, N.Wang, S.Rietdijk, M.Simarro, B.Scholtz, J.Mooney, C.H.Lee, M.S.Shin, E.Rajnavölgyi, J.Schatzle, H.C.Morse, C.Terhorst, and A.Lanyi (2006).
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.
  Immunogenetics, 58, 15-25.  
16636066 S.Frese, W.D.Schubert, A.C.Findeis, T.Marquardt, Y.S.Roske, T.E.Stradal, and D.W.Heinz (2006).
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.
  J Biol Chem, 281, 18236-18245.
PDB codes: 2ci8 2ci9 2cia
16439366 S.Lee, M.K.Ayrapetov, D.J.Kemble, K.Parang, and G.Sun (2006).
Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, C-terminal Src kinase (Csk).
  J Biol Chem, 281, 8183-8189.  
16959780 Y.P.Chong, A.S.Chan, K.C.Chan, N.A.Williamson, E.C.Lerner, T.E.Smithgall, J.D.Bjorge, D.J.Fujita, A.W.Purcell, G.Scholz, T.D.Mulhern, and H.C.Cheng (2006).
C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.
  J Biol Chem, 281, 32988-32999.  
16873552 Y.Segawa, H.Suga, N.Iwabe, C.Oneyama, T.Akagi, T.Miyata, and M.Okada (2006).
Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.
  Proc Natl Acad Sci U S A, 103, 12021-12026.  
15964839 A.K.Padyana, H.Qiu, A.Roll-Mecak, A.G.Hinnebusch, and S.K.Burley (2005).
Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.
  J Biol Chem, 280, 29289-29299.
PDB codes: 1zxe 1zy4 1zy5 1zyc 1zyd
15851033 C.H.Benes, N.Wu, A.E.Elia, T.Dharia, L.C.Cantley, and S.P.Soltoff (2005).
The C2 domain of PKCdelta is a phosphotyrosine binding domain.
  Cell, 121, 271-280.  
16158059 C.Reichman, K.Singh, Y.Liu, S.Singh, H.Li, J.E.Fajardo, A.Fiser, and R.B.Birge (2005).
Transactivation of Abl by the Crk II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain.
  Oncogene, 24, 8187-8199.  
16210316 E.C.Lerner, R.P.Trible, A.P.Schiavone, J.M.Hochrein, J.R.Engen, and T.E.Smithgall (2005).
Activation of the Src family kinase Hck without SH3-linker release.
  J Biol Chem, 280, 40832-40837.  
15866871 F.Liang, S.Y.Lee, J.Liang, D.S.Lawrence, and Z.Y.Zhang (2005).
The role of protein-tyrosine phosphatase 1B in integrin signaling.
  J Biol Chem, 280, 24857-24863.  
15618230 G.H.Iyer, M.J.Moore, and S.S.Taylor (2005).
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase.
  J Biol Chem, 280, 8800-8807.  
15961400 H.I.e.Kim, and S.T.Lee (2005).
An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.
  J Biol Chem, 280, 28973-28980.  
15851473 H.Tang, Q.Hao, S.A.Rutherford, B.Low, and Z.J.Zhao (2005).
Inactivation of SRC family tyrosine kinases by reactive oxygen species in vivo.
  J Biol Chem, 280, 23918-23925.  
15577939 J.Yang, S.M.Roe, M.J.Cliff, M.A.Williams, J.E.Ladbury, P.T.Cohen, and D.Barford (2005).
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
  EMBO J, 24, 1.
PDB code: 1wao
15880548 L.J.Ball, R.Kühne, J.Schneider-Mergener, and H.Oschkinat (2005).
Recognition of Proline-Rich Motifs by Protein-Protein-Interaction Domains.
  Angew Chem Int Ed Engl, 44, 2852-2869.  
16260764 M.A.Seeliger, M.Young, M.N.Henderson, P.Pellicena, D.S.King, A.M.Falick, and J.Kuriyan (2005).
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases.
  Protein Sci, 14, 3135-3139.  
15914019 M.I.Catalina, M.J.Fischer, F.J.Dekker, R.M.Liskamp, and A.J.Heck (2005).
Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.
  J Am Soc Mass Spectrom, 16, 1039-1051.  
15870208 M.Karplus, and J.Kuriyan (2005).
Molecular dynamics and protein function.
  Proc Natl Acad Sci U S A, 102, 6679-6685.  
16271895 N.K.Banavali, and B.Roux (2005).
The N-terminal end of the catalytic domain of SRC kinase Hck is a conformational switch implicated in long-range allosteric regulation.
  Structure, 13, 1715-1723.  
15952790 N.Yokoyama, C.D.deBakker, F.Zappacosta, M.J.Huddleston, R.S.Annan, K.S.Ravichandran, and W.T.Miller (2005).
Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.
  Biochemistry, 44, 8841-8849.  
15623523 S.A.Lieser, C.Shindler, B.E.Aubol, S.Lee, G.Sun, and J.A.Adams (2005).
Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition.
  J Biol Chem, 280, 7769-7776.  
16005629 S.J.Shattil (2005).
Integrins and Src: dynamic duo of adhesion signaling.
  Trends Cell Biol, 15, 399-403.  
16272732 S.Okombi, J.Schmidt, A.M.Mariotte, E.Perrier, and A.Boumendjel (2005).
A one-step synthesis of 2-Alkyl-5-hydroxychromones and 3-Alkoyl-2-alkyl-5-hydroxychromones.
  Chem Pharm Bull (Tokyo), 53, 1460-1462.  
15939018 S.W.Cowan-Jacob, G.Fendrich, P.W.Manley, W.Jahnke, D.Fabbro, J.Liebetanz, and T.Meyer (2005).
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation.
  Structure, 13, 861-871.
PDB code: 1y57
16166631 S.Xu, J.Huo, J.E.Tan, and K.P.Lam (2005).
Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development.
  Mol Cell Biol, 25, 8486-8495.  
15827961 V.Sundvold-Gjerstad, S.Granum, T.Mustelin, T.C.Andersen, T.Berge, M.J.Shapiro, V.S.Shapiro, A.Spurkland, and T.Lea (2005).
The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity.
  Eur J Immunol, 35, 1612-1620.  
16313344 W.C.Horne, A.Sanjay, A.Bruzzaniti, and R.Baron (2005).
The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function.
  Immunol Rev, 208, 106-125.  
16247798 W.K.Kim, and J.C.Ison (2005).
Survey of the geometric association of domain-domain interfaces.
  Proteins, 61, 1075-1088.  
16243715 Y.P.Chong, T.D.Mulhern, and H.C.Cheng (2005).
C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.
  Growth Factors, 23, 233-244.  
15568014 A.Citri, J.Gan, Y.Mosesson, G.Vereb, J.Szollosi, and Y.Yarden (2004).
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.
  EMBO Rep, 5, 1165-1170.  
15199125 A.Giannini, and M.J.Bijlmakers (2004).
Regulation of the Src family kinase Lck by Hsp90 and ubiquitination.
  Mol Cell Biol, 24, 5667-5676.  
15208330 A.K.Ghosh, A.L.Reddi, N.L.Rao, L.Duan, V.Band, and H.Band (2004).
Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.
  J Biol Chem, 279, 36132-36141.  
15507211 B.Canagarajah, F.C.Leskow, J.Y.Ho, H.Mischak, L.F.Saidi, M.G.Kazanietz, and J.H.Hurley (2004).
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.
  Cell, 119, 407-418.
PDB code: 1xa6
14960577 C.Yuan, and C.Kent (2004).
Identification of critical residues of choline kinase A2 from Caenorhabditis elegans.
  J Biol Chem, 279, 17801-17809.  
15457545 H.Harayama, M.Muroga, and M.Miyake (2004).
A cyclic adenosine 3',5'-monophosphate-induced tyrosine phosphorylation of Syk protein tyrosine kinase in the flagella of boar spermatozoa.
  Mol Reprod Dev, 69, 436-447.  
15543157 J.F.Ohren, H.Chen, A.Pavlovsky, C.Whitehead, E.Zhang, P.Kuffa, C.Yan, P.McConnell, C.Spessard, C.Banotai, W.T.Mueller, A.Delaney, C.Omer, J.Sebolt-Leopold, D.T.Dudley, I.K.Leung, C.Flamme, J.Warmus, M.Kaufman, S.Barrett, H.Tecle, and C.A.Hasemann (2004).
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
  Nat Struct Mol Biol, 11, 1192-1197.
PDB codes: 1s9i 1s9j
14625311 J.Felberg, D.C.Lefebvre, M.Lam, Y.Wang, D.H.Ng, D.Birkenhead, J.L.Cross, and P.Johnson (2004).
Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation.
  J Biol Chem, 279, 3455-3462.  
15173188 K.Kasahara, Y.Nakayama, K.Ikeda, Y.Fukushima, D.Matsuda, S.Horimoto, and N.Yamaguchi (2004).
Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.
  J Cell Biol, 165, 641-652.  
15143158 L.Cardone, A.Carlucci, A.Affaitati, A.Livigni, T.DeCristofaro, C.Garbi, S.Varrone, A.Ullrich, M.E.Gottesman, E.V.Avvedimento, and A.Feliciello (2004).
Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling.
  Mol Cell Biol, 24, 4613-4626.  
14757743 M.M.Gorska, S.J.Stafford, O.Cen, S.Sur, and R.Alam (2004).
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
  J Exp Med, 199, 369-379.  
15229886 N.Fernandez-Fuentes, A.Hermoso, J.Espadaler, E.Querol, F.X.Aviles, and B.Oliva (2004).
Classification of common functional loops of kinase super-families.
  Proteins, 56, 539-555.  
14708008 O.Hantschel, and G.Superti-Furga (2004).
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
  Nat Rev Mol Cell Biol, 5, 33-44.  
15147273 S.Yuzawa, N.N.Suzuki, Y.Fujioka, K.Ogura, H.Sumimoto, and F.Inagaki (2004).
A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase.
  Genes Cells, 9, 443-456.
PDB code: 1uec
14985335 Y.P.Chong, T.D.Mulhern, H.J.Zhu, D.J.Fujita, J.D.Bjorge, J.P.Tantiongco, N.Sotirellis, D.S.Lio, G.Scholz, and H.C.Cheng (2004).
A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity.
  J Biol Chem, 279, 20752-20766.  
12595692 A.E.Elia, L.C.Cantley, and M.B.Yaffe (2003).
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
  Science, 299, 1228-1231.  
14532005 A.E.Elia, P.Rellos, L.F.Haire, J.W.Chao, F.J.Ivins, K.Hoepker, D.Mohammad, L.C.Cantley, S.J.Smerdon, and M.B.Yaffe (2003).
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
  Cell, 115, 83-95.
PDB code: 1umw
12764189 D.T.Lodowski, J.A.Pitcher, W.D.Capel, R.J.Lefkowitz, and J.J.Tesmer (2003).
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
  Science, 300, 1256-1262.
PDB code: 1omw
14593208 E.G.Arias-Salgado, S.Lizano, S.Sarkar, J.S.Brugge, M.H.Ginsberg, and S.J.Shattil (2003).
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain.
  Proc Natl Acad Sci U S A, 100, 13298-13302.  
12857883 H.Friesen, K.Murphy, A.Breitkreutz, M.Tyers, and B.Andrews (2003).
Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation.
  Mol Biol Cell, 14, 3027-3040.  
12970174 J.A.Márquez, C.I.Smith, M.V.Petoukhov, P.Lo Surdo, P.T.Mattsson, M.Knekt, A.Westlund, K.Scheffzek, M.Saraste, and D.I.Svergun (2003).
Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.
  EMBO J, 22, 4616-4624.  
12473651 J.Zhou, J.Scholes, and J.T.Hsieh (2003).
Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer.
  J Biol Chem, 278, 6936-6941.  
12670404 K.Alexandropoulos, L.T.Donlin, L.Xing, and A.G.Regelmann (2003).
Sin: good or bad? A T lymphocyte perspective.
  Immunol Rev, 192, 181-195.  
12887890 K.M.Smith, R.Yacobi, and R.A.Van Etten (2003).
Autoinhibition of Bcr-Abl through its SH3 domain.
  Mol Cell, 12, 27-37.  
12748290 K.Q.Tanis, D.Veach, H.S.Duewel, W.G.Bornmann, and A.J.Koleske (2003).
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
  Mol Cell Biol, 23, 3884-3896.  
12499371 M.J.Moore, J.A.Adams, and S.S.Taylor (2003).
Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop.
  J Biol Chem, 278, 10613-10618.  
14506255 N.Yokoyama, and W.T.Miller (2003).
Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck.
  J Biol Chem, 278, 47713-47723.  
12496276 O.Cen, M.M.Gorska, S.J.Stafford, S.Sur, and R.Alam (2003).
Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.
  J Biol Chem, 278, 8837-8845.  
12654250 O.Hantschel, B.Nagar, S.Guettler, J.Kretzschmar, K.Dorey, J.Kuriyan, and G.Superti-Furga (2003).
A myristoyl/phosphotyrosine switch regulates c-Abl.
  Cell, 112, 845-857.  
12697809 P.M.Chan, S.Ilangumaran, J.La Rose, A.Chakrabartty, and R.Rottapel (2003).
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.
  Mol Cell Biol, 23, 3067-3078.  
12686600 P.Saharinen, M.Vihinen, and O.Silvennoinen (2003).
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.
  Mol Biol Cell, 14, 1448-1459.  
14551197 R.Shivakrupa, V.Radha, C.h.Sudhakar, and G.Swarup (2003).
Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.
  J Biol Chem, 278, 52188-52194.  
12654240 S.C.Harrison (2003).
Variation on an Src-like theme.
  Cell, 112, 737-740.  
14657361 S.Lee, X.Lin, N.H.Nam, K.Parang, and G.Sun (2003).
Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase.
  Proc Natl Acad Sci U S A, 100, 14707-14712.  
12707268 S.Li, N.D.Covino, E.G.Stein, J.H.Till, and S.R.Hubbard (2003).
Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.
  J Biol Chem, 278, 26007-26014.
PDB code: 1p14
12589038 S.Niu, H.Xie, and E.E.Marcantonio (2003).
Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
  Mol Biol Cell, 14, 349-360.  
12809525 W.T.Miller (2003).
Determinants of substrate recognition in nonreceptor tyrosine kinases.
  Acc Chem Res, 36, 393-400.  
12686554 X.Lin, S.Lee, and G.Sun (2003).
Functions of the activation loop in Csk protein-tyrosine kinase.
  J Biol Chem, 278, 24072-24077.  
14532001 Y.Chen, L.Deng, Y.Maeno-Hikichi, M.Lai, S.Chang, G.Chen, and J.F.Zhang (2003).
Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis.
  Cell, 115, 37-48.  
12210557 A.Boumendjel, A.Di Pietro, C.Dumontet, and D.Barron (2002).
Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.
  Med Res Rev, 22, 512-529.  
12045348 A.Boumendjel, C.Beney, N.Deka, A.M.Mariotte, M.A.Lawson, D.Trompier, H.Baubichon-Cortay, and A.Di Pietro (2002).
4-Hydroxy-6-methoxyaurones with high-affinity binding to cytosolic domain of P-glycoprotein.
  Chem Pharm Bull (Tokyo), 50, 854-856.  
12453410 A.Douangamath, F.V.Filipp, A.T.Klein, P.Barnett, P.Zou, T.Voorn-Brouwer, M.C.Vega, O.M.Mayans, M.Sattler, B.Distel, and M.Wilmanns (2002).
Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain.
  Mol Cell, 10, 1007-1017.
PDB codes: 1jqq 1n5z
11742120 A.Laederach, K.W.Cradic, K.N.Brazin, J.Zamoon, D.B.Fulton, X.Y.Huang, and A.H.Andreotti (2002).
Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization.
  Protein Sci, 11, 36-45.  
11973131 A.T.Miller, and L.J.Berg (2002).
New insights into the regulation and functions of Tec family tyrosine kinases in the immune system.
  Curr Opin Immunol, 14, 331-340.  
12086882 C.L.Sawyers (2002).
Disabling Abl-perspectives on Abl kinase regulation and cancer therapeutics.
  Cancer Cell, 1, 13-15.  
12100025 C.Yu, H.S.Yu, K.H.Sun, S.C.Hsieh, and C.Y.Tsai (2002).
Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase.
  Clin Exp Immunol, 129, 78-85.  
12181320 D.Wang, W.J.Esselman, and P.A.Cole (2002).
Substrate conformational restriction and CD45-catalyzed dephosphorylation of tail tyrosine-phosphorylated Src protein.
  J Biol Chem, 277, 40428-40433.  
11976726 E.C.Lerner, and T.E.Smithgall (2002).
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.
  Nat Struct Biol, 9, 365-369.  
12237287 G.M.Cheetham, R.M.Knegtel, J.T.Coll, S.B.Renwick, L.Swenson, P.Weber, J.A.Lippke, and D.A.Austen (2002).
Crystal structure of aurora-2, an oncogenic serine/threonine kinase.
  J Biol Chem, 277, 42419-42422.
PDB code: 1muo
12121988 H.Qiu, and W.T.Miller (2002).
Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition.
  J Biol Chem, 277, 34634-34641.  
12215220 I.Nakashima, M.Kato, A.A.Akhand, H.Suzuki, K.Takeda, K.Hossain, and Y.Kawamoto (2002).
Redox-linked signal transduction pathways for protein tyrosine kinase activation.
  Antioxid Redox Signal, 4, 517-531.  
12209126 K.A.Gallo, and G.L.Johnson (2002).
Mixed-lineage kinase control of JNK and p38 MAPK pathways.
  Nat Rev Mol Cell Biol, 3, 663-672.  
11830645 K.N.Brazin, R.J.Mallis, D.B.Fulton, and A.H.Andreotti (2002).
Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A.
  Proc Natl Acad Sci U S A, 99, 1899-1904.  
12048194 K.Sato, T.Nagao, M.Kakumoto, M.Kimoto, T.Otsuki, T.Iwasaki, A.A.Tokmakov, K.Owada, and Y.Fukami (2002).
Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.
  J Biol Chem, 277, 29568-29576.  
11955060 K.Schweimer, S.Hoffmann, F.Bauer, U.Friedrich, C.Kardinal, S.M.Feller, B.Biesinger, and H.Sticht (2002).
Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck.
  Biochemistry, 41, 5120-5130.
PDB codes: 1h92 1wa7
11943772 K.Suzuki-Inoue, D.Tulasne, Y.Shen, T.Bori-Sanz, O.Inoue, S.M.Jung, M.Moroi, R.K.Andrews, M.C.Berndt, and S.P.Watson (2002).
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling.
  J Biol Chem, 277, 21561-21566.  
12384576 L.W.Donaldson, G.Gish, T.Pawson, L.E.Kay, and J.D.Forman-Kay (2002).
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
  Proc Natl Acad Sci U S A, 99, 14053-14058.
PDB code: 1ju5
12142282 M.A.Pufall, and B.J.Graves (2002).
Autoinhibitory domains: modular effectors of cellular regulation.
  Annu Rev Cell Dev Biol, 18, 421-462.  
11994738 M.B.Yaffe (2002).
Phosphotyrosine-binding domains in signal transduction.
  Nat Rev Mol Cell Biol, 3, 177-186.  
11796103 M.B.Yaffe (2002).
MAGUK SH3 domains--swapped and stranded by their kinases?
  Structure, 10, 3-5.  
12015977 M.Huse, and J.Kuriyan (2002).
The conformational plasticity of protein kinases.
  Cell, 109, 275-282.  
  11805125 M.L.Dustin (2002).
Membrane domains and the immunological synapse: keeping T cells resting and ready.
  J Clin Invest, 109, 155-160.  
12208363 M.Minetti, C.Mallozzi, and A.M.Di Stasi (2002).
Peroxynitrite activates kinases of the src family and upregulates tyrosine phosphorylation signaling.
  Free Radic Biol Med, 33, 744-754.  
11877742 M.P.Okoh, and M.Vihinen (2002).
Interaction between Btk TH and SH3 domain.
  Biopolymers, 63, 325-334.  
12029088 M.P.Scott, F.Zappacosta, E.Y.Kim, R.S.Annan, and W.T.Miller (2002).
Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.
  J Biol Chem, 277, 28238-28246.  
12387321 M.Wigger, J.R.Eyler, S.A.Benner, W.Li, and A.G.Marshall (2002).
Fourier transform-ion cyclotron resonance mass spectrometric resolution, identification, and screening of non-covalent complexes of Hck Src homology 2 domain receptor and ligands from a 324-member peptide combinatorial library.
  J Am Soc Mass Spectrom, 13, 1162-1169.  
  19966925 N.Rao, A.K.Ghosh, P.Douillard, C.E.Andoniou, P.Zhou, and H.Band (2002).
An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.
  Signal Transduct, 2, 29-39.  
12191603 R.A.Engh, and D.Bossemeyer (2002).
Structural aspects of protein kinase control-role of conformational flexibility.
  Pharmacol Ther, 93, 99.  
11904303 S.Carréno, E.Caron, C.Cougoule, L.J.Emorine, and I.Maridonneau-Parini (2002).
p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.
  J Biol Chem, 277, 21007-21016.  
11684687 S.E.Pursglove, T.D.Mulhern, J.P.Mackay, M.G.Hinds, and G.W.Booker (2002).
The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain.
  J Biol Chem, 277, 755-762.
PDB code: 1gl5
12244095 S.J.Schreiner, A.P.Schiavone, and T.E.Smithgall (2002).
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.
  J Biol Chem, 277, 45680-45687.  
12005431 S.T.Arold, M.K.Hoellerer, and M.E.Noble (2002).
The structural basis of localization and signaling by the focal adhesion targeting domain.
  Structure, 10, 319-327.
PDB codes: 1k04 1k05
12121645 T.S.Ulmer, J.M.Werner, and I.D.Campbell (2002).
SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn.
  Structure, 10, 901-911.  
11839491 W.A.Lim (2002).
The modular logic of signaling proteins: building allosteric switches from simple binding domains.
  Curr Opin Struct Biol, 12, 61-68.  
12191618 Y.Fukami, T.Nagao, T.Iwasaki, and K.Sato (2002).
Inhibition and activation of c-Src: the head and tail of a coin.
  Pharmacol Ther, 93, 263-270.  
11598120 A.J.Ablooglu, M.Frankel, E.Rusinova, J.B.Ross, and R.A.Kohanski (2001).
Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain.
  J Biol Chem, 276, 46933-46940.  
11285216 A.R.Pickford, S.P.Smith, D.Staunton, J.Boyd, and I.D.Campbell (2001).
The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding.
  EMBO J, 20, 1519-1529.
PDB codes: 1e88 1e8b
11779504 A.W.McGee, S.R.Dakoji, O.Olsen, D.S.Bredt, W.A.Lim, and K.E.Prehoda (2001).
Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins.
  Mol Cell, 8, 1291-1301.
PDB code: 1kjw
11329267 D.Wang, X.Y.Huang, and P.A.Cole (2001).
Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail.
  Biochemistry, 40, 2004-2010.  
11558678 F.van den Akker (2001).
Detailed analysis of the atrial natriuretic factor receptor hormone-binding domain crystal structure.
  Can J Physiol Pharmacol, 79, 692-704.  
11779506 G.A.Tavares, E.H.Panepucci, and A.T.Brunger (2001).
Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.
  Mol Cell, 8, 1313-1325.
PDB codes: 1jxm 1jxo
11518702 H.Korkaya, S.Jameel, D.Gupta, S.Tyagi, R.Kumar, M.Zafrullah, M.Mazumdar, S.K.Lal, L.Xiaofang, D.Sehgal, S.R.Das, and D.Sahal (2001).
The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
  J Biol Chem, 276, 42389-42400.  
11389851 H.Yamaguchi, M.Matsushita, A.C.Nairn, and J.Kuriyan (2001).
Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity.
  Mol Cell, 7, 1047-1057.
PDB codes: 1ia9 1iah 1iaj
11590155 H.Zhang, and K.A.Gallo (2001).
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
  J Biol Chem, 276, 45598-45603.  
11158738 J.M.Pérez-Victoria, F.J.Pérez-Victoria, G.Conseil, M.Maitrejean, G.Comte, D.Barron, A.Di Pietro, S.Castanys, and F.Gamarro (2001).
High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.
  Antimicrob Agents Chemother, 45, 439-446.  
11551213 J.Shaffer, G.Sun, and J.A.Adams (2001).
Nucleotide release and associated conformational changes regulate function in the COOH-terminal Src kinase, Csk.
  Biochemistry, 40, 11149-11155.  
11779503 J.W.Wu, M.Hu, J.Chai, J.Seoane, M.Huse, C.Li, D.J.Rigotti, S.Kyin, T.W.Muir, R.Fairman, J.Massagué, and Y.Shi (2001).
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
  Mol Cell, 8, 1277-1289.
PDB code: 1khx
11316885 K.V.Kishan, M.E.Newcomer, T.H.Rhodes, and S.D.Guilliot (2001).
Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain.
  Protein Sci, 10, 1046-1055.
PDB codes: 1i07 1i0c
  11913947 L.B.Justement (2001).
The role of the protein tyrosine phosphatase CD45 in regulation of B lymphocyte activation.
  Int Rev Immunol, 20, 713-738.  
11572780 L.E.Wybenga-Groot, B.Baskin, S.H.Ong, J.Tong, T.Pawson, and F.Sicheri (2001).
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
  Cell, 106, 745-757.
PDB code: 1jpa
11157779 L.Xing, A.M.Venegas, A.Chen, L.Garrett-Beal, B.F.Boyce, H.E.Varmus, and P.L.Schwartzberg (2001).
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.
  Genes Dev, 15, 241-253.  
11687495 M.A.Shogren-Knaak, P.J.Alaimo, and K.M.Shokat (2001).
Recent advances in chemical approaches to the study of biological systems.
  Annu Rev Cell Dev Biol, 17, 405-433.  
11301007 M.A.Young, S.Gonfloni, G.Superti-Furga, B.Roux, and J.Kuriyan (2001).
Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation.
  Cell, 105, 115-126.  
11605670 M.Hadjeri, A.M.Mariotte, and A.Boumendjel (2001).
Alkylation of 2-phenyl-4-quinolones: synthetic and structural studies.
  Chem Pharm Bull (Tokyo), 49, 1352-1355.  
11354004 M.Miller, K.Ginalski, B.Lesyng, N.Nakaigawa, L.Schmidt, and B.Zbar (2001).
Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies.
  Proteins, 44, 32-43.  
11406576 M.Nishida, K.Nagata, Y.Hachimori, M.Horiuchi, K.Ogura, V.Mandiyan, J.Schlessinger, and F.Inagaki (2001).
Novel recognition mode between Vav and Grb2 SH3 domains.
  EMBO J, 20, 2995-3007.
PDB codes: 1gcp 1gcq
11258891 N.Beglova, C.L.North, and S.C.Blacklow (2001).
Backbone dynamics of a module pair from the ligand-binding domain of the LDL receptor.
  Biochemistry, 40, 2808-2815.  
11391566 N.V.Prabhu, S.A.Siddiqui, J.S.McMurray, and B.M.Pettitt (2001).
Structural basis for the activity of pp60(c-src) protein tyrosine kinase inhibitors.
  Biopolymers, 59, 167-179.  
11470597 P.J.Alaimo, M.A.Shogren-Knaak, and K.M.Shokat (2001).
Chemical genetic approaches for the elucidation of signaling pathways.
  Curr Opin Chem Biol, 5, 360-367.  
11440715 R.Dajani, E.Fraser, S.M.Roe, N.Young, V.Good, T.C.Dale, and L.H.Pearl (2001).
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.
  Cell, 105, 721-732.
PDB code: 1h8f
11558677 R.K.Sharma, P.Yadav, and T.Duda (2001).
Allosteric regulatory step and configuration of the ATP-binding pocket in atrial natriuretic factor receptor guanylate cyclase transduction mechanism.
  Can J Physiol Pharmacol, 79, 682-691.  
15992165 S.H.Coleman, J.R.Day, and J.C.Guatelli (2001).
The HIV-1 Nef protein as a target for antiretroviral therapy.
  Expert Opin Ther Targets, 5, 1.  
11244041 S.K.Bromley, W.R.Burack, K.G.Johnson, K.Somersalo, T.N.Sims, C.Sumen, M.M.Davis, A.S.Shaw, P.M.Allen, and M.L.Dustin (2001).
The immunological synapse.
  Annu Rev Immunol, 19, 375-396.  
11336673 S.M.Shamah, M.Z.Lin, J.L.Goldberg, S.Estrach, M.Sahin, L.Hu, M.Bazalakova, R.L.Neve, G.Corfas, A.Debant, and M.E.Greenberg (2001).
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin.
  Cell, 105, 233-244.  
11376431 T.R.Burke, Z.J.Yao, D.G.Liu, J.Voigt, and Y.Gao (2001).
Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors.
  Biopolymers, 60, 32-44.  
10940260 A.Bishop, O.Buzko, S.Heyeck-Dumas, I.Jung, B.Kraybill, Y.Liu, K.Shah, S.Ulrich, L.Witucki, F.Yang, C.Zhang, and K.M.Shokat (2000).
Unnatural ligands for engineered proteins: new tools for chemical genetics.
  Annu Rev Biophys Biomol Struct, 29, 577-606.  
11012022 A.F.Burchat, D.J.Calderwood, G.C.Hirst, N.J.Holman, D.N.Johnston, R.Munschauer, P.Rafferty, and G.B.Tometzki (2000).
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
  Bioorg Med Chem Lett, 10, 2171-2174.  
10933796 A.Y.Jan, E.F.Johnson, A.J.Diamonti, K.L.Carraway III, and K.S.Anderson (2000).
Insights into the HER-2 receptor tyrosine kinase mechanism and substrate specificity using a transient kinetic analysis.
  Biochemistry, 39, 9786-9803.  
11094067 B.J.Irvin, B.L.Williams, A.E.Nilson, H.O.Maynor, and R.T.Abraham (2000).
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
  Mol Cell Biol, 20, 9149-9161.  
10629042 C.E.Andoniou, N.L.Lill, C.B.Thien, M.L.Lupher, S.Ota, D.D.Bowtell, R.M.Scaife, W.Y.Langdon, and H.Band (2000).
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.
  Mol Cell Biol, 20, 851-867.  
  10739251 D.A.Horita, W.Zhang, T.E.Smithgall, W.H.Gmeiner, and R.A.Byrd (2000).
Dynamics of the Hck-SH3 domain: comparison of experiment with multiple molecular dynamics simulations.
  Protein Sci, 9, 95.  
11106755 D.Durocher, I.A.Taylor, D.Sarbassova, L.F.Haire, S.L.Westcott, S.P.Jackson, S.J.Smerdon, and M.B.Yaffe (2000).
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
  Mol Cell, 6, 1169-1182.
PDB code: 1g6g
11090628 E.H.Walker, M.E.Pacold, O.Perisic, L.Stephens, P.T.Hawkins, M.P.Wymann, and R.L.Williams (2000).
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
  Mol Cell, 6, 909-919.
PDB codes: 1e7u 1e7v 1e8w 1e8x 1e8y 1e8z 1e90
  11071920 G.Bottger, P.Barnett, A.T.Klein, A.Kragt, H.F.Tabak, and B.Distel (2000).
Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.
  Mol Biol Cell, 11, 3963-3976.  
10841772 G.Conseil, A.Decottignies, J.M.Jault, G.Comte, D.Barron, A.Goffeau, and A.Di Pietro (2000).
Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.
  Biochemistry, 39, 6910-6917.  
10692391 G.G.Chiang, and B.M.Sefton (2000).
Phosphorylation of a Src kinase at the autophosphorylation site in the absence of Src kinase activity.
  J Biol Chem, 275, 6055-6058.  
10799548 G.Scholz, K.Cartledge, and A.R.Dunn (2000).
Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
  J Biol Chem, 275, 14615-14623.  
10958693 G.Scholz, S.D.Hartson, K.Cartledge, N.Hall, J.Shao, A.R.Dunn, and R.L.Matts (2000).
p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.
  Mol Cell Biol, 20, 6984-6995.  
11060025 H.Wu, C.Reissner, S.Kuhlendahl, B.Coblentz, S.Reuver, S.Kindler, E.D.Gundelfinger, and C.C.Garner (2000).
Intramolecular interactions regulate SAP97 binding to GKAP.
  EMBO J, 19, 5740-5751.  
10713991 K.A.Denessiouk, and M.S.Johnson (2000).
When fold is not important: a common structural framework for adenine and AMP binding in 12 unrelated protein families.
  Proteins, 38, 310-326.  
10848605 K.L.Binns, P.P.Taylor, F.Sicheri, T.Pawson, and S.J.Holland (2000).
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.
  Mol Cell Biol, 20, 4791-4805.  
11012021 L.D.Arnold, D.J.Calderwood, R.W.Dixon, D.N.Johnston, J.S.Kamens, R.Munschauer, P.Rafferty, and S.E.Ratnofsky (2000).
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.
  Bioorg Med Chem Lett, 10, 2167-2170.  
10625501 L.Konkol, T.J.Hirai, and J.A.Adams (2000).
Substrate specificity of the oncoprotein v-Fps: site-specific mutagenesis of the putative P+1 pocket.
  Biochemistry, 39, 255-262.  
10893547 L.Sun, and G.McMahon (2000).
Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors.
  Drug Discov Today, 5, 344-353.  
10982853 L.Xing, C.Ge, R.Zeltser, G.Maskevitch, B.J.Mayer, and K.Alexandropoulos (2000).
c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.
  Mol Cell Biol, 20, 7363-7377.  
  10793137 M.J.Bijlmakers, and M.Marsh (2000).
Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).
  Mol Biol Cell, 11, 1585-1595.  
10644735 M.Porter, T.Schindler, J.Kuriyan, and W.T.Miller (2000).
Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand.
  J Biol Chem, 275, 2721-2726.  
10913170 M.R.Burnham, P.J.Bruce-Staskal, M.T.Harte, C.L.Weidow, A.Ma, S.A.Weed, and A.H.Bouton (2000).
Regulation of c-SRC activity and function by the adapter protein CAS.
  Mol Cell Biol, 20, 5865-5878.  
11121839 M.Susva, M.Missbach, and J.Green (2000).
Src inhibitors: drugs for the treatment of osteoporosis, cancer or both?
  Trends Pharmacol Sci, 21, 489-495.  
10848956 N.Isakov, and B.Biesinger (2000).
Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.
  Eur J Biochem, 267, 3413-3421.  
10779328 P.Saharinen, K.Takaluoma, and O.Silvennoinen (2000).
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain.
  Mol Cell Biol, 20, 3387-3395.  
10777567 R.T.Glover, M.Angiolieri, S.Kelly, D.T.Monaghan, J.Y.Wang, T.E.Smithgall, and A.L.Buller (2000).
Interaction of the N-methyl-D-aspartic acid receptor NR2D subunit with the c-Abl tyrosine kinase.
  J Biol Chem, 275, 12725-12729.  
10642173 S.D.Briggs, E.C.Lerner, and T.E.Smithgall (2000).
Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.
  Biochemistry, 39, 489-495.  
  11087177 S.Inouye, R.Jain, T.Ueki, H.Nariya, C.Y.Xu, M.Y.Hsu, B.A.Fernandez-Luque, J.Munoz-Dorado, E.Farez-Vidal, and M.Inouye (2000).
A large family of eukaryotic-like protein Ser/Thr kinases of Myxococcus xanthus, a developmental bacterium.
  Microb Comp Genomics, 5, 103-120.  
  11152127 S.M.Larson, and A.R.Davidson (2000).
The identification of conserved interactions within the SH3 domain by alignment of sequences and structures.
  Protein Sci, 9, 2170-2180.  
11106432 S.M.Robbins, N.A.Quintrell, and J.M.Bishop (2000).
Mercuric chloride activates the Src-family protein tyrosine kinase, Hck in myelomonocytic cells.
  Eur J Biochem, 267, 7201-7208.  
10966463 S.R.Hubbard, and J.H.Till (2000).
Protein tyrosine kinase structure and function.
  Annu Rev Biochem, 69, 373-398.  
10829062 T.Shishido, T.Akagi, T.Ouchi, M.M.Georgescu, W.Y.Langdon, and H.Hanafusa (2000).
The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.
  Proc Natl Acad Sci U S A, 97, 6439-6444.  
10698938 X.M.Zheng, R.J.Resnick, and D.Shalloway (2000).
A phosphotyrosine displacement mechanism for activation of Src by PTPalpha.
  EMBO J, 19, 964-978.  
11007482 Y.C.Ma, J.Huang, S.Ali, W.Lowry, and X.Y.Huang (2000).
Src tyrosine kinase is a novel direct effector of G proteins.
  Cell, 102, 635-646.  
11087392 Y.Liu, L.A.Witucki, K.Shah, A.C.Bishop, and K.M.Shokat (2000).
Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities.
  Biochemistry, 39, 14400-14408.  
10669752 Z.Honda, T.Suzuki, H.Kono, M.Okada, T.Yamamoto, C.Ra, Y.Morita, and K.Yamamoto (2000).
Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.
  Mol Cell Biol, 20, 1759-1771.  
10464322 A.A.Akhand, M.Pu, T.Senga, M.Kato, H.Suzuki, T.Miyata, M.Hamaguchi, and I.Nakashima (1999).
Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism.
  J Biol Chem, 274, 25821-25826.  
10430626 A.D.Holdorf, J.M.Green, S.D.Levin, M.F.Denny, D.B.Straus, V.Link, P.S.Changelian, P.M.Allen, and A.S.Shaw (1999).
Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation.
  J Exp Med, 190, 375-384.  
  10364375 A.L.Greenway, H.Dutartre, K.Allen, D.A.McPhee, D.Olive, and Y.Collette (1999).
Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.
  J Virol, 73, 6152-6158.  
10454200 A.Levitzki (1999).
Protein tyrosine kinase inhibitors as novel therapeutic agents.
  Pharmacol Ther, 82, 231-239.  
10066823 A.M.Brunati, A.Donella-Deana, P.James, M.Quadroni, A.Contri, O.Marin, and L.A.Pinna (1999).
Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.
  J Biol Chem, 274, 7557-7564.  
10391941 A.W.Craig, R.Zirngibl, and P.Greer (1999).
Disruption of coiled-coil domains in Fer protein-tyrosine kinase abolishes trimerization but not kinase activation.
  J Biol Chem, 274, 19934-19942.  
  10091661 B.J.Stapley, and T.P.Creamer (1999).
A survey of left-handed polyproline II helices.
  Protein Sci, 8, 587-595.  
10398926 C.B.Post, B.S.Gaul, E.Z.Eisenmesser, and M.L.Schneider (1999).
NMR structure of phospho-tyrosine signaling complexes.
  Med Res Rev, 19, 295-305.  
10194304 C.L.North, and S.C.Blacklow (1999).
Structural independence of ligand-binding modules five and six of the LDL receptor.
  Biochemistry, 38, 3926-3935.  
10205168 C.S.Mason, C.J.Springer, R.G.Cooper, G.Superti-Furga, C.J.Marshall, and R.Marais (1999).
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
  EMBO J, 18, 2137-2148.  
10400611 D.A.Hartley, T.R.Hurley, J.S.Hardwick, T.C.Lund, P.G.Medveczky, and B.M.Sefton (1999).
Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation.
  J Biol Chem, 274, 20056-20059.  
10196227 D.C.Edwards, and G.N.Gill (1999).
Structural features of LIM kinase that control effects on the actin cytoskeleton.
  J Biol Chem, 274, 11352-11361.  
10339551 G.Wang, G.P.Wylie, P.D.Twigg, D.L.Caspar, J.R.Murphy, and T.M.Logan (1999).
Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein.
  Proc Natl Acad Sci U S A, 96, 6119-6124.
PDB code: 1bym
  10567558 H.Cheng, J.A.Rogers, N.A.Dunham, and T.E.Smithgall (1999).
Regulation of c-Fes tyrosine kinase and biological activities by N-terminal coiled-coil oligomerization domains.
  Mol Cell Biol, 19, 8335-8343.  
10647781 H.Mano (1999).
Tec family of protein-tyrosine kinases: an overview of their structure and function.
  Cytokine Growth Factor Rev, 10, 267-280.  
10449731 H.Oda, S.Kumar, and P.M.Howley (1999).
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.
  Proc Natl Acad Sci U S A, 96, 9557-9562.  
  10564270 J.B.McCabe, and L.G.Berthiaume (1999).
Functional roles for fatty acylated amino-terminal domains in subcellular localization.
  Mol Biol Cell, 10, 3771-3786.  
10607674 J.D.Forman-Kay, and T.Pawson (1999).
Diversity in protein recognition by PTB domains.
  Curr Opin Struct Biol, 9, 690-695.  
9874568 J.F.Cloutier, and A.Veillette (1999).
Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase.
  J Exp Med, 189, 111-121.  
9988744 J.H.Till, P.M.Chan, and W.T.Miller (1999).
Engineering the substrate specificity of the Abl tyrosine kinase.
  J Biol Chem, 274, 4995-5003.  
10488144 J.M.Smith, S.Katz, and B.J.Mayer (1999).
Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.
  J Biol Chem, 274, 27956-27962.  
10454194 J.M.Sowadski, L.F.Epstein, L.Lankiewicz, and R.Karlsson (1999).
Conformational diversity of catalytic cores of protein kinases.
  Pharmacol Ther, 82, 157-164.  
10413466 J.R.Engen, W.H.Gmeiner, T.E.Smithgall, and D.L.Smith (1999).
Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
  Biochemistry, 38, 8926-8935.  
10386963 L.A.Kobierski, A.E.Wong, S.Srivastava, D.Borsook, and S.E.Hyman (1999).
Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase.
  J Neurochem, 73, 129-138.  
  10512882 M.D.Schaller, J.D.Hildebrand, and J.T.Parsons (1999).
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.
  Mol Biol Cell, 10, 3489-3505.  
9988764 M.F.Denny, H.C.Kaufman, A.C.Chan, and D.B.Straus (1999).
The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.
  J Biol Chem, 274, 5146-5152.  
10025408 M.Huse, Y.G.Chen, J.Massagué, and J.Kuriyan (1999).
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.
  Cell, 96, 425-436.
PDB code: 1b6c
10187789 M.Matsushita, and A.C.Nairn (1999).
Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.
  J Biol Chem, 274, 10086-10093.  
10318843 M.Pelosi, V.Di Bartolo, V.Mounier, D.Mège, J.M.Pascussi, E.Dufour, A.Blondel, and O.Acuto (1999).
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
  J Biol Chem, 274, 14229-14237.  
10029530 N.Narayana, T.C.Diller, K.Koide, M.E.Bunnage, K.C.Nicolaou, L.L.Brunton, N.H.Xuong, L.F.Ten Eyck, and S.S.Taylor (1999).
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
  Biochemistry, 38, 2367-2376.
PDB code: 1bx6
10454199 P.A.Cole, D.Sondhi, and K.Kim (1999).
Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design.
  Pharmacol Ther, 82, 219-229.  
10454197 P.Traxler, and P.Furet (1999).
Strategies toward the design of novel and selective protein tyrosine kinase inhibitors.
  Pharmacol Ther, 82, 195-206.  
10090735 Q.Xu, J.Zheng, R.Xu, G.Barany, and D.Cowburn (1999).
Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH(32) of abelson.
  Biochemistry, 38, 3491-3497.  
10336376 R.Schleif (1999).
Arm-domain interactions in proteins: a review.
  Proteins, 34, 1-3.  
10473622 S.D.Briggs, and T.E.Smithgall (1999).
SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.
  J Biol Chem, 274, 26579-26583.  
10074361 S.M.Bishop, J.B.Ross, and R.A.Kohanski (1999).
Autophosphorylation dependent destabilization of the insulin receptor kinase domain: tryptophan-1175 reports changes in the catalytic cleft.
  Biochemistry, 38, 3079-3089.  
10092645 S.Mahajan, S.Ghosh, E.A.Sudbeck, Y.Zheng, S.Downs, M.Hupke, and F.M.Uckun (1999).
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide].
  J Biol Chem, 274, 9587-9599.  
10454192 S.S.Taylor, E.Radzio-Andzelm, Madhusudan, X.Cheng, L.Ten Eyck, and N.Narayana (1999).
Catalytic subunit of cyclic AMP-dependent protein kinase: structure and dynamics of the active site cleft.
  Pharmacol Ther, 82, 133-141.  
10791898 S.Sinha, and S.J.Corey (1999).
Implications for Src kinases in hematopoiesis: signal transduction therapeutics.
  J Hematother Stem Cell Res, 8, 465-480.  
10559253 T.Ago, H.Nunoi, T.Ito, and H.Sumimoto (1999).
Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase.
  J Biol Chem, 274, 33644-33653.  
10358768 T.Kurosaki (1999).
Genetic analysis of B cell antigen receptor signaling.
  Annu Rev Immunol, 17, 555-592.  
10360180 T.Schindler, F.Sicheri, A.Pico, A.Gazit, A.Levitzki, and J.Kuriyan (1999).
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.
  Mol Cell, 3, 639-648.
PDB code: 1qcf
10339589 T.Yamadori, Y.Baba, M.Matsushita, S.Hashimoto, M.Kurosaki, T.Kurosaki, T.Kishimoto, and S.Tsukada (1999).
Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.
  Proc Natl Acad Sci U S A, 96, 6341-6346.  
  10490624 V.S.Kasi, and D.Kuppuswamy (1999).
Inhibition of src family kinases by a combinatorial action of 5'-AMP and small heat shock proteins, identified from the adult heart.
  Mol Cell Biol, 19, 6858-6871.  
10360179 W.Xu, A.Doshi, M.Lei, M.J.Eck, and S.C.Harrison (1999).
Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
  Mol Cell, 3, 629-638.
PDB code: 2src
10404594 X.Zhu, J.L.Kim, J.R.Newcomb, P.E.Rose, D.R.Stover, L.M.Toledo, H.Zhao, and K.A.Morgenstern (1999).
Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
  Structure, 7, 651-661.
PDB codes: 1qpc 1qpd 1qpe 1qpj
10508617 Y.Hakak, and G.S.Martin (1999).
Ubiquitin-dependent degradation of active Src.
  Curr Biol, 9, 1039-1042.  
10467133 Y.Liu, A.Bishop, L.Witucki, B.Kraybill, E.Shimizu, J.Tsien, J.Ubersax, J.Blethrow, D.O.Morgan, and K.M.Shokat (1999).
Structural basis for selective inhibition of Src family kinases by PP1.
  Chem Biol, 6, 671-678.  
9989791 Y.Ma, B.J.Longley, X.Wang, J.L.Blount, K.Langley, and G.H.Caughey (1999).
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms.
  J Invest Dermatol, 112, 165-170.  
10224103 Y.Ma, M.E.Cunningham, X.Wang, I.Ghosh, L.Regan, and B.J.Longley (1999).
Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region.
  J Biol Chem, 274, 13399-13402.  
9501066 A.C.Bishop, K.Shah, Y.Liu, L.Witucki, C.Kung, and K.M.Shokat (1998).
Design of allele-specific inhibitors to probe protein kinase signaling.
  Curr Biol, 8, 257-266.  
9698376 A.D.Cann, S.M.Bishop, A.J.Ablooglu, and R.A.Kohanski (1998).
Partial activation of the insulin receptor kinase domain by juxtamembrane autophosphorylation.
  Biochemistry, 37, 11289-11300.  
9477973 A.Donella-Deana, L.Cesaro, M.Ruzzene, A.M.Brunati, O.Marin, and L.A.Pinna (1998).
Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity.
  Biochemistry, 37, 1438-1446.  
  9584165 B.Y.Chang, K.B.Conroy, E.M.Machleder, and C.A.Cartwright (1998).
RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.
  Mol Cell Biol, 18, 3245-3256.  
9618763 C.I.Smith, C.M.Bäckesjö, A.Berglöf, L.J.Brandén, T.Islam, P.T.Mattsson, A.J.Mohamed, S.Müller, B.Nore, and M.Vihinen (1998).
X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.
  Springer Semin Immunopathol, 19, 369-381.  
9759495 D.A.Fruman, R.E.Meyers, and L.C.Cantley (1998).
Phosphoinositide kinases.
  Annu Rev Biochem, 67, 481-507.  
9551546 D.Barford, and B.G.Neel (1998).
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
  Structure, 6, 249-254.  
9500553 D.Barilá, and G.Superti-Furga (1998).
An intramolecular SH3-domain interaction regulates c-Abl activity.
  Nat Genet, 18, 280-282.  
9425036 D.Sondhi, W.Xu, Z.Songyang, M.J.Eck, and P.A.Cole (1998).
Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism.
  Biochemistry, 37, 165-172.  
9817025, J.J.Wu, and K.S.Lam (1998).
Protein tyrosine kinases: structure, substrate specificity, and drug discovery.
  Biopolymers, 47, 197-223.  
9707561 G.Conseil, H.Baubichon-Cortay, G.Dayan, J.M.Jault, D.Barron, and A.Di Pietro (1998).
Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.
  Proc Natl Acad Sci U S A, 95, 9831-9836.  
9485443 H.Hansson, P.T.Mattsson, P.Allard, P.Haapaniemi, M.Vihinen, C.I.Smith, and T.Hard (1998).
Solution structure of the SH3 domain from Bruton's tyrosine kinase.
  Biochemistry, 37, 2912-2924.
PDB codes: 1aww 1awx
9677430 H.Lin, J.E.Hutchcroft, C.E.Andoniou, M.Kamoun, H.Band, and B.E.Bierer (1998).
Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.
  J Biol Chem, 273, 19914-19921.  
9700498 I.D.Campbell (1998).
The modular architecture of leukocyte cell-surface receptors.
  Immunol Rev, 163, 11-18.  
9612082 J.C.Williams, R.K.Wierenga, and M.Saraste (1998).
Insights into Src kinase functions: structural comparisons.
  Trends Biochem Sci, 23, 179-184.  
9763421 J.D.Gary, A.E.Wurmser, C.J.Bonangelino, L.S.Weisman, and S.D.Emr (1998).
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis.
  J Cell Biol, 143, 65-79.  
9651387 J.Felberg, and P.Johnson (1998).
Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions.
  J Biol Chem, 273, 17839-17845.  
9570401 J.Reizer, C.Hoischen, F.Titgemeyer, C.Rivolta, R.Rabus, J.Stülke, D.Karamata, M.H.Saier, and W.Hillen (1998).
A novel protein kinase that controls carbon catabolite repression in bacteria.
  Mol Microbiol, 27, 1157-1169.  
9417118 J.W.Thomas, B.Ellis, R.J.Boerner, W.B.Knight, G.C.White, and M.D.Schaller (1998).
SH2- and SH3-mediated interactions between focal adhesion kinase and Src.
  J Biol Chem, 273, 577-583.  
  9566904 J.Wong, D.Straus, and A.C.Chan (1998).
Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.
  Mol Cell Biol, 18, 2855-2866.  
9662064 J.Y.Wang (1998).
Protein kinases entering the information age.
  J Biomed Sci, 5, 73.  
9461621 K.Hata, T.Ito, K.Takeshige, and H.Sumimoto (1998).
Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions.
  J Biol Chem, 273, 4232-4236.  
9839441 M.D.Resh (1998).
Fyn, a Src family tyrosine kinase.
  Int J Biochem Cell Biol, 30, 1159-1162.  
  9774683 M.Daub, J.Jöckel, T.Quack, C.K.Weber, F.Schmitz, U.R.Rapp, A.Wittinghofer, and C.Block (1998).
The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation.
  Mol Cell Biol, 18, 6698-6710.  
9739093 M.Holford, and T.W.Muir (1998).
Adding 'splice' to protein engineering.
  Structure, 6, 951-956.  
  9566880 M.J.Wallace, C.Fladd, J.Batt, and D.Rotin (1998).
The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.
  Mol Cell Biol, 18, 2608-2616.  
9822689 M.LaFevre-Bernt, F.Sicheri, A.Pico, M.Porter, J.Kuriyan, and W.T.Miller (1998).
Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue.
  J Biol Chem, 273, 32129-32134.  
9662509 P.Cohen, and M.Goedert (1998).
Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid.
  Chem Biol, 5, R161-R164.  
9491886 P.Hof, S.Pluskey, S.Dhe-Paganon, M.J.Eck, and S.E.Shoelson (1998).
Crystal structure of the tyrosine phosphatase SHP-2.
  Cell, 92, 441-450.
PDB code: 2shp
9687503 P.Lock, C.L.Abram, T.Gibson, and S.A.Courtneidge (1998).
A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate.
  EMBO J, 17, 4346-4357.  
9624111 P.Pellicena, K.R.Stowell, and W.T.Miller (1998).
Enhanced phosphorylation of Src family kinase substrates containing SH2 domain binding sites.
  J Biol Chem, 273, 15325-15328.  
  9573250 R.A.Lutzke, and R.H.Plasterk (1998).
Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding.
  J Virol, 72, 4841-4848.  
9642231 R.J.Sicilia, M.L.Hibbs, P.A.Bello, J.D.Bjorge, D.J.Fujita, I.J.Stanley, A.R.Dunn, and H.C.Cheng (1998).
Common in vitro substrate specificity and differential Src homology 2 domain accessibility displayed by two members of the Src family of protein-tyrosine kinases, c-Src and Hck.
  J Biol Chem, 273, 16756-16763.  
9629920 R.K.Rasmussen, H.Ji, J.S.Eddes, R.L.Moritz, G.E.Reid, R.J.Simpson, and D.S.Dorow (1998).
Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins.
  Electrophoresis, 19, 809-817.  
9642269 R.M.Baxter, J.P.Secrist, R.R.Vaillancourt, and A.Kazlauskas (1998).
Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events.
  J Biol Chem, 273, 17050-17055.  
9778343 S.Arold, R.O'Brien, P.Franken, M.P.Strub, F.Hoh, C.Dumas, and J.E.Ladbury (1998).
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.
  Biochemistry, 37, 14683-14691.
PDB code: 1bu1
  9447984 S.Corbalan-Garcia, S.M.Margarit, D.Galron, S.S.Yang, and D.Bar-Sagi (1998).
Regulation of Sos activity by intramolecular interactions.
  Mol Cell Biol, 18, 880-886.  
9525961 S.D.Hartson, E.A.Ottinger, W.Huang, G.Barany, P.Burn, and R.L.Matts (1998).
Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase.
  J Biol Chem, 273, 8475-8482.  
9452436 S.J.Corey, P.M.Dombrosky-Ferlan, S.Zuo, E.Krohn, A.D.Donnenberg, P.Zorich, G.Romero, M.Takata, and T.Kurosaki (1998).
Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.
  J Biol Chem, 273, 3230-3235.  
9593201 S.Knapp, P.T.Mattson, P.Christova, K.D.Berndt, A.Karshikoff, M.Vihinen, C.I.Smith, and R.Ladenstein (1998).
Thermal unfolding of small proteins with SH3 domain folding pattern.
  Proteins, 31, 309-319.  
9564038 S.Okada, M.Matsuda, M.Anafi, T.Pawson, and J.E.Pessin (1998).
Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.
  EMBO J, 17, 2554-2565.  
9548930 S.Qin, T.Kurosaki, and H.Yamamura (1998).
Differential regulation of oxidative and osmotic stress induced Syk activation by both autophosphorylation and SH2 domains.
  Biochemistry, 37, 5481-5486.  
9575136 S.R.Hubbard, M.Mohammadi, and J.Schlessinger (1998).
Autoregulatory mechanisms in protein-tyrosine kinases.
  J Biol Chem, 273, 11987-11990.  
9435218 S.Shaltiel, S.Cox, and S.S.Taylor (1998).
Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A.
  Proc Natl Acad Sci U S A, 95, 484-491.  
9618476 T.W.Muir, D.Sondhi, and P.A.Cole (1998).
Expressed protein ligation: a general method for protein engineering.
  Proc Natl Acad Sci U S A, 95, 6705-6710.  
9753329 V.D.Rao, S.Misra, I.V.Boronenkov, R.A.Anderson, and J.H.Hurley (1998).
Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.
  Cell, 94, 829-839.
PDB code: 1bo1
9585523 W.Zhang, T.E.Smithgall, and W.H.Gmeiner (1998).
Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms.
  Biochemistry, 37, 7119-7126.  
9770463 Y.C.Ma, and X.Y.Huang (1998).
Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase.
  Proc Natl Acad Sci U S A, 95, 12197-12201.  
9115388 B.J.Mayer (1997).
Signal transduction: clamping down on Src activity.
  Curr Biol, 7, R295-R298.  
9368069 B.K.Jaitner, J.Becker, T.Linnemann, C.Herrmann, A.Wittinghofer, and C.Block (1997).
Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysis.
  J Biol Chem, 272, 29927-29933.  
9252391 C.C.Mastick, and A.R.Saltiel (1997).
Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells.
  J Biol Chem, 272, 20706-20714.  
9566119 D.C.Dalgarno, M.C.Botfield, and R.J.Rickles (1997).
SH3 domains and drug design: ligands, structure, and biological function.
  Biopolymers, 43, 383-400.  
9287362 D.Davidson, J.F.Cloutier, A.Gregorieff, and A.Veillette (1997).
Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells.
  J Biol Chem, 272, 23455-23462.  
9362479 E.D.Lowe, M.E.Noble, V.T.Skamnaki, N.G.Oikonomakos, D.J.Owen, and L.N.Johnson (1997).
The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
  EMBO J, 16, 6646-6658.
PDB code: 2phk
9342381 F.Onofri, S.Giovedì, P.Vaccaro, A.J.Czernik, F.Valtorta, P.De Camilli, P.Greengard, and F.Benfenati (1997).
Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity.
  Proc Natl Acad Sci U S A, 94, 12168-12173.  
9434895 F.Sicheri, and J.Kuriyan (1997).
Structures of Src-family tyrosine kinases.
  Curr Opin Struct Biol, 7, 777-785.  
9204760 G.Superti-Furga, and S.Gonfloni (1997).
A crystal milestone: the structure of regulated Src.
  Bioessays, 19, 447-450.  
9535169 H.D.Showalter, and A.J.Kraker (1997).
Small molecule inhibitors of the platelet-derived growth factor receptor, the fibroblast growth factor receptor, and Src family tyrosine kinases.
  Pharmacol Ther, 76, 55-71.  
9408950 H.V.Patel, S.R.Tzeng, C.Y.Liao, S.H.Chen, and J.W.Cheng (1997).
SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl.
  Proteins, 29, 545-552.  
9374534 J.Couet, M.Sargiacomo, and M.P.Lisanti (1997).
Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities.
  J Biol Chem, 272, 30429-30438.  
9394826 J.Kobarg, G.S.Whitney, D.Palmer, A.Aruffo, and M.A.Bowen (1997).
Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains.
  Eur J Immunol, 27, 2971-2980.  
9241420 J.Kuriyan, and D.Cowburn (1997).
Modular peptide recognition domains in eukaryotic signaling.
  Annu Rev Biophys Biomol Struct, 26, 259-288.  
9667874 J.P.Wery, and R.W.Schevitz (1997).
New trends in macromolecular X-ray crystallography.
  Curr Opin Chem Biol, 1, 365-369.  
9398156 J.R.Engen, T.E.Smithgall, W.H.Gmeiner, and D.L.Smith (1997).
Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.
  Biochemistry, 36, 14384-14391.  
9325251 J.S.Hardwick, and B.M.Sefton (1997).
The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505.
  J Biol Chem, 272, 25429-25432.  
9362531 J.Sloan-Lancaster, W.Zhang, J.Presley, B.L.Williams, R.T.Abraham, J.Lippincott-Schwartz, and L.E.Samelson (1997).
Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.
  J Exp Med, 186, 1713-1724.  
9095189 J.T.Nguyen, and W.A.Lim (1997).
How Src exercises self-restraint.
  Nat Struct Biol, 4, 256-260.  
9326643 M.I.Wahl, A.C.Fluckiger, R.M.Kato, H.Park, O.N.Witte, and D.J.Rawlings (1997).
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
  Proc Natl Acad Sci U S A, 94, 11526-11533.  
9407116 M.Warmuth, M.Bergmann, A.Priess, K.Häuslmann, B.Emmerich, and M.Hallek (1997).
The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
  J Biol Chem, 272, 33260-33270.  
9250364 R.L.Brockbank, and H.J.Vogel (1997).
NMR studies of the RRsrc peptide, a tyrosine kinase substrate.
  Biochem Cell Biol, 75, 163-169.  
9351809 S.Arold, P.Franken, M.P.Strub, F.Hoh, S.Benichou, R.Benarous, and C.Dumas (1997).
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
  Structure, 5, 1361-1372.
PDB codes: 1avv 1avz
  17708948 S.D, and T.S J (1997).
Src: more than the sum of its parts.
  Trends Cell Biol, 7, 215-217.  
9218412 S.D.Briggs, M.Sharkey, M.Stevenson, and T.E.Smithgall (1997).
SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.
  J Biol Chem, 272, 17899-17902.  
9287186 S.Desiderio (1997).
Role of Btk in B cell development and signaling.
  Curr Opin Immunol, 9, 534-540.  
9405355 S.Gonfloni, J.C.Williams, K.Hattula, A.Weijland, R.K.Wierenga, and G.Superti-Furga (1997).
The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.
  EMBO J, 16, 7261-7271.  
9442882 S.M.Thomas, and J.S.Brugge (1997).
Cellular functions regulated by Src family kinases.
  Annu Rev Cell Dev Biol, 13, 513-609.  
9667861 S.S.Taylor, and E.Radzio-Andzelm (1997).
Protein kinase inhibition: natural and synthetic variations on a theme.
  Curr Opin Chem Biol, 1, 219-226.  
  9334312 S.T.Wen, and R.A.Van Etten (1997).
The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.
  Genes Dev, 11, 2456-2467.  
9351806 T.D.Mulhern, G.L.Shaw, C.J.Morton, A.J.Day, and I.D.Campbell (1997).
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
  Structure, 5, 1313-1323.
PDB codes: 1aot 1aou
9235982 T.P.Stauffer, C.H.Martenson, J.E.Rider, B.K.Kay, and T.Meyer (1997).
Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides.
  Biochemistry, 36, 9388-9394.  
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