PDBsum entry: 2hbu

Oxidoreductase

PDB id: 2hbu

Contents

Protein chain

219 a.a. *

Ligands

UN9

Metals

FE2

Waters ×121

* Residue conservation analysis

PDB id:

2hbu

Name:

Oxidoreductase

Title:

Crystal structure of hif prolyl hydroxylase egln-1 in complex with a biologically active inhibitor

Structure:

Egl nine homolog 1. Chain: a. Fragment: catalytic domain. Synonym: hypoxia-inducible factor prolyl hydroxylase 2, hif-prolyl hydroxylase 2, hif-ph2, hph-2, prolyl hydroxylase domain-containing protein 2, phd2, sm-20. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egln1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Trimer (from PQS)

Resolution:

1.85Å R-factor: 0.181 R-free: 0.231

Authors:

A.G.Evdokimov,R.L.Walter,M.Mekel,M.E.Pokross,R.Kawamoto, A.Boyer

Key ref:

A.G.Evdokimov et al. Crystal structure of hif prolyl hydroxylase in complex with a biologically active inhibitor. To be published,

Date:

14-Jun-06 Release date: 27-Jun-06

Protein chain

Q9GZT9  (EGLN1_HUMAN) -  Egl nine homolog 1

Seq: 426 a.a.

Struc: 219 a.a.

Enzyme reactions

• Enzyme class: E.C.1.14.11.29 - Hypoxia-inducible factor-proline dioxygenase.
• Reaction: Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O₂ = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO₂
• Cofactor: Iron; L-ascorbate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: oxidation-reduction process (1 term)
• Biochemical function: oxidoreductase activity (5 terms)