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PDBsum entry 2gp0

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protein ligands links
Hydrolase PDB id
2gp0
Jmol
Contents
Protein chain
288 a.a. *
Ligands
PO4
GOL
Waters ×297
* Residue conservation analysis
PDB id:
2gp0
Name: Hydrolase
Title: Heptp catalytic domain (residues 44-339), s225d mutant
Structure: Tyrosine-protein phosphatase non-receptor type 7. Chain: a. Fragment: catalytic domain (residues 65-360). Synonym: protein-tyrosine phosphatase lc-ptp, hematopoietic tyrosine phosphatase, heptp. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn7. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.05Å     R-factor:   0.179     R-free:   0.206
Authors: R.Page
Key ref: R.Page and t.mustelin Heptp catalytic domain (residues 44-339), S225d mutant. To be published, .
Date:
15-Apr-06     Release date:   09-May-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P35236  (PTN7_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 7
Seq:
Struc:
360 a.a.
288 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+
phosphate
Bound ligand (Het Group name = PO4)
corresponds exactly
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms