PDBsum entry: 2gk9

Transferase

PDB id: 2gk9

Contents

Protein chains

243 a.a. *

245 a.a. *

* Residue conservation analysis

PDB id:

2gk9

Name:

Transferase

Title:

Human phosphatidylinositol-4-phosphate 5-kinase, type ii, gamma

Structure:

Phosphatidylinositol-4-phosphate 5-kinase, type ii, gamma. Chain: a, b, c, d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pip5k2c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Tetramer (from PQS)

Resolution:

2.80Å R-factor: 0.261 R-free: 0.297

Authors:

J.Uppenberg,M.Hogbom,D.Ogg,C.Arrowsmith,H.Berglund, R.Collins,M.Ehn,S.Flodin,A.Flores,S.Graslund,L.Holmberg- Schiavone,A.Edwards,M.Hammarstrom,T.Kotenyova,P.Nilsson- Ehle,P.Nordlund,T.Nyman,C.Persson,J.Sagemark,P.Stenmark, M.Sundstrom,A.G.Thorsell,S.Van Den Berg,J.Weigelt, B.M.Hallberg,Structural Genomics Consortium (Sgc)

Key ref:

A.G.Thorsell et al. Structure of human phosphatidylinositol-4-Phosphate 5-Kinase, Type ii, Gamma. To be published,

Date:

31-Mar-06 Release date: 02-May-06

Protein chains

Q8TBX8  (PI42C_HUMAN) -  Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma

Seq: 421 a.a.

Struc: 243 a.a.*

Protein chain

Q8TBX8  (PI42C_HUMAN) -  Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma

Seq: 421 a.a.

Struc: 245 a.a.*

* PDB and UniProt seqs differ at 50 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase.
• Pathway: 1-Phosphatidyl-myo-inositol Metabolism
• Reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: membrane (2 terms)
• Biological process: phosphatidylinositol metabolic process (1 term)
• Biochemical function: nucleotide binding (7 terms)