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PDBsum entry 2g44

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protein ligands Protein-protein interface(s) links
Hormone/growth factor receptor PDB id
2g44
Jmol
Contents
Protein chains
237 a.a. *
Ligands
LYS-ILE-LEU-HIS-
ARG-LEU-LEU-GLN-
ASP
×2
T3O ×2
Waters ×6
* Residue conservation analysis
PDB id:
2g44
Name: Hormone/growth factor receptor
Title: Human estrogen receptor alpha ligand-binding domain in compl obcp-1m-g and a glucocorticoid receptor interacting protein ii peptide
Structure: Estrogen receptor. Chain: a, b. Fragment: ligand binding domain. Synonym: er, estradiol receptor, er-alpha. Engineered: yes. Mutation: yes. Nuclear receptor coactivator 2. Chain: c, d. Fragment: grip peptide.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: esr1, esr, nr3a1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapie (humans).
Resolution:
2.65Å     R-factor:   0.219     R-free:   0.256
Authors: S.S.Rajan,R.W.Hsieh,S.K.Sharma,G.L.Greene
Key ref: R.W.Hsieh Discovery and characterization of novel estrogen receptor agonist ligands and development of biochips for nuclear receptor drug discovery. Thesis, .
Date:
21-Feb-06     Release date:   09-Jan-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P03372  (ESR1_HUMAN) -  Estrogen receptor
Seq:
Struc:
 
Seq:
Struc:
595 a.a.
237 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     3 terms