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PDBsum entry 2f8a

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2f8a
Jmol
Contents
Protein chain
186 a.a. *
Ligands
MLA ×2
Waters ×411
* Residue conservation analysis
PDB id:
2f8a
Name: Oxidoreductase
Title: Crystal structure of the selenocysteine to glycine mutant of glutathione peroxidase 1
Structure: Glutathione peroxidase 1. Chain: a, b. Fragment: residues 12-196. Synonym: gshpx-1, gpx-1, cellular glutathione peroxidase. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Biol. unit: Tetramer (from PDB file)
Resolution:
1.50Å     R-factor:   0.138     R-free:   0.156
Authors: K.L.Kavanagh,C.Johansson,C.Smee,O.Gileadi,F.Von Delft,J.Weig M.Sundstrom,A.Edwards,U.Oppermann,Structural Genomics Conso (Sgc)
Key ref: K.L.Kavanagh et al. Crystal structure of the selenocysteine to glycine mu of human glutathione peroxidase 1. To be published, .
Date:
02-Dec-05     Release date:   13-Dec-05    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P07203  (GPX1_HUMAN) -  Glutathione peroxidase 1
Seq:
Struc:
203 a.a.
186 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.11.1.9  - Glutathione peroxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
2 × glutathione
+ H(2)O(2)
= glutathione disulfide
+ 2 × H(2)O
      Cofactor: Se(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   7 terms 
  Biological process     small molecule metabolic process   61 terms 
  Biochemical function     selenium binding     7 terms