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PDBsum entry 2f6r

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protein ligands links
Transferase PDB id
2f6r
Jmol
Contents
Protein chain
230 a.a. *
Ligands
ACO
UNL
Waters ×199
* Residue conservation analysis
PDB id:
2f6r
Name: Transferase
Title: Crystal structure of bifunctional coenzyme a synthase (coa s (18044849) from mus musculus at 1.70 a resolution
Structure: Bifunctional coenzyme a synthase. Chain: a. Fragment: phosphopantetheine adenylyltransferase and dephos kinase. Synonym: coa synthase. Pantetheine- phosphate adenylyltrans ppat dephospho-coa pyrophosphorylase. Dpck, dephosphocoenzy kinase, dpcoak. Engineered: yes. Mutation: yes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: coasy, ukr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
1.70Å     R-factor:   0.180     R-free:   0.211
Authors: Joint Center For Structural Genomics (Jcsg)
Key ref: Joint center for structural genomics (jcsg) Crystal structure of bifunctional coenzyme a synthase (coa synthase) (18044849) from mus musculus at 1.70 a resolution. To be published, .
Date:
29-Nov-05     Release date:   27-Dec-05    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9DBL7  (COASY_MOUSE) -  Bifunctional coenzyme A synthase
Seq:
Struc:
 
Seq:
Struc:
563 a.a.
230 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.2.7.1.24  - Dephospho-CoA kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Coenzyme A Biosynthesis (late stages)
      Reaction: ATP + 3'-dephospho-CoA = ADP + CoA
ATP
+ 3'-dephospho-CoA
= ADP
+
CoA
Bound ligand (Het Group name = ACO)
matches with 94.12% similarity
   Enzyme class 3: E.C.2.7.7.3  - Pantetheine-phosphate adenylyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
ATP
Bound ligand (Het Group name = ACO)
matches with 49.09% similarity
+ pantetheine 4'-phosphate
= diphosphate
+ 3'-dephospho-CoA
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     coenzyme A biosynthetic process   1 term 
  Biochemical function     dephospho-CoA kinase activity     2 terms