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PDBsum entry 2f2d

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protein links
Isomerase PDB id
2f2d
Jmol
Contents
Protein chain
121 a.a. *
* Residue conservation analysis
PDB id:
2f2d
Name: Isomerase
Title: Solution structure of the fk506-binding domain of human fkbp38
Structure: 38 kda fk-506 binding protein homolog, fkbp38. Chain: a. Fragment: fk506-binding domain, residues 35-153. Synonym: fkbpr38, fk506-binding protein 8. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp8, fkbp38. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
NMR struc: 20 models
Authors: M.Maestre-Martinez,F.Edlich,F.Jarczowski,M.Weiwad,G.Fischer, C.Luecke
Key ref: M.Maestre-Martínez et al. (2006). Solution structure of the FK506-binding domain of human FKBP38. J Biomol NMR, 34, 197-202. PubMed id: 16604427
Date:
16-Nov-05     Release date:   02-May-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q14318  (FKBP8_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP8
Seq:
Struc:
412 a.a.
121 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein folding   1 term 

 

 
J Biomol NMR 34:197-202 (2006)
PubMed id: 16604427  
 
 
Solution structure of the FK506-binding domain of human FKBP38.
M.Maestre-Martínez, F.Edlich, F.Jarczowski, M.Weiwad, G.Fischer, C.Lücke.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20140889 M.Maestre-Martínez, K.Haupt, F.Edlich, P.Neumann, C.Parthier, M.T.Stubbs, G.Fischer, and C.Lücke (2011).
A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.
  J Mol Recognit, 24, 23-34.
PDB code: 3ey6
20707607 M.Maestre-Martínez, K.Haupt, F.Edlich, G.Jahreis, F.Jarczowski, F.Erdmann, G.Fischer, and C.Lücke (2010).
New structural aspects of FKBP38 activation.
  Biol Chem, 391, 1157-1167.  
19255428 S.E.Ong, M.Schenone, A.A.Margolin, X.Li, K.Do, M.K.Doud, D.R.Mani, L.Kuai, X.Wang, J.L.Wood, N.J.Tolliday, A.N.Koehler, L.A.Marcaurelle, T.R.Golub, R.J.Gould, S.L.Schreiber, and S.A.Carr (2009).
Identifying the proteins to which small-molecule probes and drugs bind in cells.
  Proc Natl Acad Sci U S A, 106, 4617-4622.  
18498106 C.Stordeur, R.Dallüge, O.Birkenmeier, H.Wienk, R.Rudolph, C.Lange, and C.Lücke (2008).
The NMR solution structure of the artificial protein M7 matches the computationally designed model.
  Proteins, 72, 1104-1107.
PDB code: 2jvf
18658153 D.Ma, X.Bai, S.Guo, and Y.Jiang (2008).
The switch I region of Rheb is critical for its interaction with FKBP38.
  J Biol Chem, 283, 25963-25970.  
18214965 J.A.Somarelli, S.Y.Lee, J.Skolnick, and R.J.Herrera (2008).
Structure-based classification of 45 FK506-binding proteins.
  Proteins, 72, 197-208.  
17942410 F.Edlich, M.Maestre-Martínez, F.Jarczowski, M.Weiwad, M.C.Moutty, M.Malesević, G.Jahreis, G.Fischer, and C.Lücke (2007).
A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38.
  J Biol Chem, 282, 36496-36504.  
17826298 M.Geisler, and A.Bailly (2007).
Tête-à-tête: the function of FKBPs in plant development.
  Trends Plant Sci, 12, 465-473.  
  19704625 A.Bailly, V.Sovero, and M.Geisler (2006).
The Twisted Dwarf's ABC: How Immunophilins Regulate Auxin Transport.
  Plant Signal Behav, 1, 277-280.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.