PDBsum entry 2f2d

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protein links
Isomerase PDB id
Protein chain
121 a.a. *
* Residue conservation analysis
PDB id:
Name: Isomerase
Title: Solution structure of the fk506-binding domain of human fkbp38
Structure: 38 kda fk-506 binding protein homolog, fkbp38. Chain: a. Fragment: fk506-binding domain, residues 35-153. Synonym: fkbpr38, fk506-binding protein 8. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp8, fkbp38. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
NMR struc: 20 models
Authors: M.Maestre-Martinez,F.Edlich,F.Jarczowski,M.Weiwad,G.Fischer, C.Luecke
Key ref: M.Maestre-Martínez et al. (2006). Solution structure of the FK506-binding domain of human FKBP38. J Biomol NMR, 34, 197-202. PubMed id: 16604427
16-Nov-05     Release date:   02-May-06    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
Q14318  (FKBP8_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP8
412 a.a.
121 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein folding   1 term 


J Biomol NMR 34:197-202 (2006)
PubMed id: 16604427  
Solution structure of the FK506-binding domain of human FKBP38.
M.Maestre-Martínez, F.Edlich, F.Jarczowski, M.Weiwad, G.Fischer, C.Lücke.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
20140889 M.Maestre-Martínez, K.Haupt, F.Edlich, P.Neumann, C.Parthier, M.T.Stubbs, G.Fischer, and C.Lücke (2011).
A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.
  J Mol Recognit, 24, 23-34.
PDB code: 3ey6
20707607 M.Maestre-Martínez, K.Haupt, F.Edlich, G.Jahreis, F.Jarczowski, F.Erdmann, G.Fischer, and C.Lücke (2010).
New structural aspects of FKBP38 activation.
  Biol Chem, 391, 1157-1167.  
19255428 S.E.Ong, M.Schenone, A.A.Margolin, X.Li, K.Do, M.K.Doud, D.R.Mani, L.Kuai, X.Wang, J.L.Wood, N.J.Tolliday, A.N.Koehler, L.A.Marcaurelle, T.R.Golub, R.J.Gould, S.L.Schreiber, and S.A.Carr (2009).
Identifying the proteins to which small-molecule probes and drugs bind in cells.
  Proc Natl Acad Sci U S A, 106, 4617-4622.  
18498106 C.Stordeur, R.Dallüge, O.Birkenmeier, H.Wienk, R.Rudolph, C.Lange, and C.Lücke (2008).
The NMR solution structure of the artificial protein M7 matches the computationally designed model.
  Proteins, 72, 1104-1107.
PDB code: 2jvf
18658153 D.Ma, X.Bai, S.Guo, and Y.Jiang (2008).
The switch I region of Rheb is critical for its interaction with FKBP38.
  J Biol Chem, 283, 25963-25970.  
18214965 J.A.Somarelli, S.Y.Lee, J.Skolnick, and R.J.Herrera (2008).
Structure-based classification of 45 FK506-binding proteins.
  Proteins, 72, 197-208.  
17942410 F.Edlich, M.Maestre-Martínez, F.Jarczowski, M.Weiwad, M.C.Moutty, M.Malesević, G.Jahreis, G.Fischer, and C.Lücke (2007).
A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38.
  J Biol Chem, 282, 36496-36504.  
17826298 M.Geisler, and A.Bailly (2007).
Tête-à-tête: the function of FKBPs in plant development.
  Trends Plant Sci, 12, 465-473.  
  19704625 A.Bailly, V.Sovero, and M.Geisler (2006).
The Twisted Dwarf's ABC: How Immunophilins Regulate Auxin Transport.
  Plant Signal Behav, 1, 277-280.  
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