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PDBsum entry 2f13

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protein ligands links
Hydrolase PDB id
2f13
Jmol
Contents
Protein chain
351 a.a. *
Ligands
PO4
DYM
Waters ×190
* Residue conservation analysis
PDB id:
2f13
Name: Hydrolase
Title: Crystal structure of the human sialidase neu2 in complex with 2',3'- dihydroxypropyl ether mimetic inhibitor
Structure: Sialidase 2. Chain: a. Synonym: neu2, cytosolic sialidase, n-acetyl-alpha- neuraminidase 2. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Resolution:
2.26Å     R-factor:   0.194     R-free:   0.241
Authors: L.M.G.Chavas,R.Kato,M.C.Mann,R.J.Thomson,J.C.Dyason,M.Von Itzstein,P.Fusi,C.Tringali,B.Venerando,G.Tettamanti,E.Monti S.Wakatsuki
Key ref: L.M.G.Chavas et al. Crystal structure of the human sialidase neu2 in complex with 2',3'- Dihydroxypropyl ether mimetic inhibitor. To be published, .
Date:
14-Nov-05     Release date:   21-Nov-06    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9Y3R4  (NEUR2_HUMAN) -  Sialidase-2
Seq:
Struc:
380 a.a.
351 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   2 terms 
  Biological process     metabolic process   9 terms 
  Biochemical function     exo-alpha-(2->3)-sialidase activity     6 terms