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PDBsum entry 2f12
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Crystal structure of the human sialidase neu2 in complex with 3- hydroxypropyl ether mimetic inhibitor
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Structure:
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Sialidase 2. Chain: a. Synonym: neu2, cytosolic sialidase, n-acetyl-alpha- neuraminidase 2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Resolution:
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2.27Å
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R-factor:
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0.200
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R-free:
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0.250
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Authors:
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L.M.G.Chavas,R.Kato,M.C.Mann,R.J.Thomson,J.C.Dyason,M.Von Itzstein, P.Fusi,C.Tringali,B.Venerando,G.Tettamanti,E.Monti,S.Wakatsuki
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Key ref:
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L.M.G.Chavas
et al.
Crystal structure of the human sialidase neu2 in complex with 3- Hydroxypropyl ether mimetic inhibitor.
To be published,
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Date:
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14-Nov-05
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Release date:
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21-Nov-06
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PROCHECK
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Headers
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References
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Q9Y3R4
(NEUR2_HUMAN) -
Sialidase-2 from Homo sapiens
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Seq:
Struc:
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380 a.a.
359 a.a.*
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Key: |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.2.1.18
- exo-alpha-sialidase.
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Reaction:
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Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
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Links
