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PDBsum entry 2eqi

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protein links
Immune system, hydrolase PDB id
2eqi
Jmol
Contents
Protein chain
69 a.a. *
* Residue conservation analysis
PDB id:
2eqi
Name: Immune system, hydrolase
Title: Solution structure of the sh3 domain from phospholipasE C, gamma 2
Structure: PhospholipasE C, gamma 2. Chain: a. Fragment: sh3 domain. Engineered: yes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: plcg2. Other_details: cell-free protein synthesis
NMR struc: 20 models
Authors: X.R.Qin,T.Nagashima,F.Hayahsi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: X.R.Qin et al. Solution structure of the sh3 domain from phospholipase c, Gamma 2. To be published, .
Date:
30-Mar-07     Release date:   08-Apr-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8CIH5  (PLCG2_MOUSE) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1265 a.a.
69 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 12 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.4.11  - Phosphoinositide phospholipase C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
myo-Inositol Phosphate Metabolism
      Reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
+ H(2)O
= 1D-myo-inositol 1,4,5-trisphosphate
+ diacylglycerol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     intracellular signal transduction   2 terms 
  Biochemical function     phosphatidylinositol phospholipase C activity     1 term