PDBsum entry: 2enq

Transferase

PDB id: 2enq

Contents

Protein chain

158 a.a. *

* Residue conservation analysis

PDB id:

2enq

Name:

Transferase

Title:

Solution structure of the c2 domain from human pi3-kinase p110 subunit alpha

Structure:

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform. Chain: a. Fragment: c2 domain. Synonym: pi3-kinase p110 subunit alpha, ptdins-3- kinase p110, pi3k. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3ca. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

H.Endo,T.Nagashima,M.Yoshida,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Endo et al. Solution structure of the c2 domain from human pi3-Kinase p110 subunit alpha. To be published,

Date:

28-Mar-07 Release date: 01-Apr-08

Protein chain

P42336  (PK3CA_HUMAN) -  Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Seq: 1068 a.a.

Struc: 158 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: E.C.2.7.1.153 - Phosphatidylinositol-4,5-bisphosphate 3-kinase.
• Pathway: 1-Phosphatidyl-myo-inositol Metabolism
• Reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
• Enzyme class 3: E.C.2.7.11.1 - Non-specific serine/threonine protein kinase.
• Reaction: ATP + a protein = ADP + a phosphoprotein

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: phosphatidylinositol 3-kinase complex (1 term)
• Biological process: phosphatidylinositol-mediated signaling (2 terms)
• Biochemical function: protein binding (3 terms)