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Lyase PDB id
2eja
Jmol
Contents
Protein chains
337 a.a. *
Ligands
ACT
Waters ×751
* Residue conservation analysis
PDB id:
2eja
Name: Lyase
Title: Crystal structure of uroporphyrinogen decarboxylase from aquifex aeolicus
Structure: Uroporphyrinogen decarboxylase. Chain: a, b. Synonym: uro-d, upd. Engineered: yes
Source: Aquifex aeolicus. Organism_taxid: 63363. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.205     R-free:   0.270
Authors: B.Bagautdinov,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: B.Bagautdinov and n.kunishima Crystal structure of uroporphyrinogen decarboxylase from aquifex aeolicus. To be published,
Date:
16-Mar-07     Release date:   18-Mar-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
O66667  (DCUP_AQUAE) -  Uroporphyrinogen decarboxylase
Seq:
Struc: 		338 a.a.
337 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.1.1.37  - Uroporphyrinogen decarboxylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		Porphyrin Biosynthesis (later stages)
      Reaction: Uroporphyrinogen III = coproporphyrinogen + 4 CO2
Uroporphyrinogen III
 = coproporphyrinogen
 +
4 × CO(2)
Bound ligand (Het Group name = ACT)
matches with 75.00% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     porphyrin biosynthetic process   1 term 
  Biochemical function     lyase activity     3 terms