PDBsum entry: 2eh6

Transferase

PDB id

2eh6

Contents

			Protein chains

					375 a.a. *

			Ligands

					PLP ×2

			Waters ×506

* Residue conservation analysis

PDB id:

2eh6

Links
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Name:

Transferase

Title:

Crystal structure of acetylornithine aminotransferase from a aeolicus vf5

Structure:

Acetylornithine aminotransferase. Chain: a, b. Synonym: acoat. Engineered: yes

Source:

Aquifex aeolicus. Organism_taxid: 224324. Strain: vf5. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.90Å

R-factor:

0.198

R-free:

0.221

Authors:

H.Mizutani,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Mizutani and n.kunishima Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5. To be published,

Date:

05-Mar-07

Release date:

11-Sep-07

PROCHECK

	Headers

	References

Protein chains

O66442 (ARGD_AQUAE) - Acetylornithine aminotransferase

Seq: Struc:					376 a.a. 375 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.6.1.11 - Acetylornithine transaminase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Ornithine Biosynthesis

Reaction:

N₂-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

N(2)-acetyl-L-ornithine	+	2-oxoglutarate	=	N-acetyl-L-glutamate 5-semialdehyde	+	L-glutamate

Cofactor:

Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate
Bound ligand (Het Group name = PLP) matches with 93.75% similarity

Molecule diagrams generated from .mol files obtained from the KEGG ftp site



		Gene Ontology (GO) functional annotation

Cellular component	cytoplasm	1 term
Biological process	cellular amino acid biosynthetic process	3 terms
Biochemical function	catalytic activity	5 terms