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protein ligands Protein-protein interface(s) links
Transferase PDB id
2efy
Jmol
Contents
Protein chains
302 a.a. *
Ligands
PLP ×2
4AT ×2
Waters ×161
* Residue conservation analysis
PDB id:
2efy
Name: Transferase
Title: Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase with 4-acetylbutyric acid
Structure: O-acetylserine (thiol)-lyase. Chain: a, b. Synonym: o-acetylserine sulfhydrylase, cysteine synthase. Engineered: yes
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.35Å     R-factor:   0.193     R-free:   0.238
Authors: M.Goto
Key ref: M.Goto Crystal structure of t.Th. Hb8 o-Acetylserine sulfhydrylase complexed with 4-Acetylbutyric acid. To be published,
Date:
26-Feb-07     Release date:   26-Feb-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q5SLE6  (Q5SLE6_THET8) -  Cysteine synthase
Seq:
Struc: 		304 a.a.
302 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.2.5.1.47  - Cysteine synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate
O(3)-acetyl-L-serine
 + H(2)S
 =
L-cysteine
Bound ligand (Het Group name = 4AT)
matches with 45.45% similarity 		+ acetate
      Cofactor: Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
Bound ligand (Het Group name = PLP) matches with 93.75% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   4 terms 
  Biochemical function     catalytic activity     5 terms