PDBsum entry: 2ec9

Blood clotting

PDB id: 2ec9

Contents

Protein chains

142 a.a. *

254 a.a. *

75 a.a. *

116 a.a. *

Ligands

ASO

FUC

24X

Metals

_CA ×9

Waters ×224

* Residue conservation analysis

PDB id:

2ec9

Name:

Blood clotting

Title:

Crystal structure analysis of human factor viia , souluble t factor complexed with bcx-3607

Structure:

Coagulation factor vii. Chain: l. Fragment: residues 1-142. Synonym: serum prothrombin conversion accelerator, spca, proconvertin, eptacog alfa. Engineered: yes. Coagulation factor vii. Chain: h. Fragment: residues 16-257.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.00Å R-factor: 0.242 R-free: 0.282

Authors:

K.Raman,B.Yarlagadda

Key ref:

K.Raman et al. Crystal structure analysis of human factor viia , Souluble tissue factor complexed with bcx-3607. To be published,

Date:

13-Feb-07 Release date: 19-Feb-08

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII

Seq: 466 a.a.

Struc: 142 a.a.*

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII

Seq: 466 a.a.

Struc: 254 a.a.

Protein chain

P13726  (TF_HUMAN) -  Tissue factor

Seq: 295 a.a.

Struc: 75 a.a.

Protein chain

P13726  (TF_HUMAN) -  Tissue factor

Seq: 295 a.a.

Struc: 116 a.a.

* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.21 - Coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (2 terms)
• Biological process: blood coagulation (2 terms)
• Biochemical function: catalytic activity (4 terms)