PDBsum entry: 2e6i

Transferase

PDB id: 2e6i

Contents

Protein chain

64 a.a. *

Metals

_ZN

* Residue conservation analysis

PDB id:

2e6i

Name:

Transferase

Title:

Solution structure of the btk motif of tyrosine-protein kinase itk from human

Structure:

Tyrosine-protein kinase itk/tsk. Chain: a. Fragment: btk motif. Synonym: t-cell-specific kinase, tyrosine-protein kinase lyk, kinase emt. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: itk. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

H.Li,N.Tochio,S.Koshiba,S.Watanabe,T.Harada,T.Kigawa, S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Li et al. Solution structure of the btk motif of tyrosine-Protein kinase itk from human. To be published,

Date:

27-Dec-06 Release date: 03-Jul-07

Protein chain

Q08881  (ITK_HUMAN) -  Tyrosine-protein kinase ITK/TSK

Seq: 620 a.a.

Struc: 64 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - Non-specific protein-tyrosine kinase.
• Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytosol (1 term)
• Biological process: intracellular signal transduction (1 term)