PDBsum entry: 2e5m

Oxidoreductase

PDB id

2e5m

Contents

			Protein chains

					403 a.a. *

			Ligands

					NAP ×2

			Waters ×405

* Residue conservation analysis

PDB id:

2e5m

Links
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Name:

Oxidoreductase

Title:

Crystal structure of isocitrate dehydrogenase from sulfolobu strain 7

Structure:

409aa long hypothetical NADP-dependent isocitrate dehydrogenase. Chain: a, b. Synonym: isocitrate dehydrogenase. Engineered: yes

Source:

Sulfolobus tokodaii str. 7. Organism_taxid: 273063. Strain: strain 7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.40Å

R-factor:

0.217

R-free:

0.279

Authors:

T.Kouyama,H.Kondo

Key ref:

T.Kouyama and h.kondo Isocitrate dehydrogenase from sulfolobus tokodaii strain 7. To be published,

Date:

22-Dec-06

Release date:

15-Jan-08

PROCHECK

	Headers

	References

Protein chains

Q96YK6 (Q96YK6_SULTO) - Isocitrate dehydrogenase

Seq: Struc:					409 a.a. 403 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.1.1.1.42 - Isocitrate dehydrogenase (NADP(+)).

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Citric acid cycle

Reaction:

Isocitrate + NADP⁺ = 2-oxoglutarate + CO₂ + NADPH

Isocitrate	+	NADP(+)	=	2-oxoglutarate	+	CO(2)	+	NADPH

Cofactor:

Manganese or magnesium

Molecule diagrams generated from .mol files obtained from the KEGG ftp site



		Gene Ontology (GO) functional annotation

Biological process	oxidation-reduction process	2 terms
Biochemical function	nucleotide binding	6 terms