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Transcription/DNA
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PDB id
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2e42
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Contents |
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* Residue conservation analysis
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PDB id:
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Transcription/DNA
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Title:
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Crystal structure of c/ebpbeta bzip homodimer v285a mutant bound to a high affinity DNA fragment
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Structure:
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Ccaat/enhancer-binding protein beta. Chain: a, b. Fragment: residues 259-336. Synonym: c/ebp beta, nuclear factor nf-il6, transcription factor 5. Engineered: yes. Mutation: yes. DNA (5'- d(p Dtp Dap Dgp Dgp Dap Dtp Dtp Dgp Dcp Dgp Dcp Dap Dap Dtp
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cebpb, tcf5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
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Resolution:
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1.80Å
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R-factor:
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0.232
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R-free:
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0.252
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Authors:
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T.H.Tahirov,T.Inoue-Bungo,K.Sato,M.Shiina,K.Hamada,K.Ogata
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Key ref:
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T.H.Tahirov
et al.
Structural basis for flexible base recognition by c/ebpbeta.
To be published,
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Date:
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01-Dec-06
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Release date:
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18-Dec-07
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PROCHECK
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Headers
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References
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P17676
(CEBPB_HUMAN) -
CCAAT/enhancer-binding protein beta
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Seq:
Struc:
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345 a.a.
65 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Gene Ontology (GO) functional annotation
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Cellular component
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nucleus
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1 term
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Biological process
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regulation of transcription, DNA-dependent
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1 term
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Biochemical function
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transcription factor activity
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3 terms
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Links
