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PDBsum entry 2e3x

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protein ligands metals Protein-protein interface(s) links
Hydrolase, blood clotting, toxin PDB id
2e3x
Jmol
Contents
Protein chains
416 a.a. *
129 a.a. *
120 a.a. *
Ligands
NAG ×2
NAG-NAG
NAG-NAG-MAN-MAN
GM6
Metals
_CA ×5
_ZN
* Residue conservation analysis
PDB id:
2e3x
Name: Hydrolase, blood clotting, toxin
Title: Crystal structure of russell's viper venom metalloproteinase
Structure: Coagulation factor x-activating enzyme heavy chai chain: a. Synonym: rvv-x heavy chain, coagulation factor x-activating alpha-chain, russellysin. Coagulation factor x-activating enzyme light chai chain: b. Synonym: rvv-x light chain 1, coagulation factor x-activati beta-chain, c-type lectin-like protein subunit 1, rvv-x lig a.
Source: Daboia russellii siamensis. Organism_taxid: 343250. Strain: siamensis. Secretion: venom. Secretion: venom
Resolution:
2.91Å     R-factor:   0.218     R-free:   0.273
Authors: T.Igarashi,S.Takeda
Key ref: S.Takeda et al. Crystal structure of rvv-X: an example of evolutionary gain of specificity by adam proteinases. Febs lett., .
Date:
30-Nov-06     Release date:   11-Dec-07    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q7LZ61  (VM3CX_DABRU) -  Coagulation factor X-activating enzyme heavy chain
Seq:
Struc:
 
Seq:
Struc:
619 a.a.
416 a.a.*
Protein chain
Pfam   ArchSchema ?
Q4PRD2  (LC2_DABRU) -  Snaclec coagulation factor X-activating enzyme light chain 2
Seq:
Struc:
158 a.a.
129 a.a.
Protein chain
Pfam   ArchSchema ?
Q4PRD1  (LC1_DABRU) -  Snaclec coagulation factor X-activating enzyme light chain 1
Seq:
Struc:
146 a.a.
120 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain A: E.C.3.4.24.58  - Russellysin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of Arg-|-Xaa bonds. Has no action on insulin B chain.
      Cofactor: Calcium; Zinc
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     proteolysis   1 term 
  Biochemical function     carbohydrate binding     4 terms