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PDBsum entry 2e37

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2e37
Jmol
Contents
Protein chains
(+ 2 more) 308 a.a. *
Ligands
NAD ×4
SO4 ×2
Waters ×829
* Residue conservation analysis
PDB id:
2e37
Name: Oxidoreductase
Title: Structure of tt0471 protein from thermus thermophilus
Structure: L-lactate dehydrogenase. Chain: a, b, c, d, e, f, g, h. Synonym: l-ldh, NAD binding dehydrogenase. Engineered: yes
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
2.30Å     R-factor:   0.215     R-free:   0.255
Authors: N.K.Lokanath,Riken Structural Genomics/proteomics Initiative
Key ref: N.K.Lokanath and n.kunishima Structure of tt0471 protein from thermus thermophilus. To be published, .
Date:
21-Nov-06     Release date:   27-Nov-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q5SJA1  (LDH_THET8) -  L-lactate dehydrogenase
Seq:
Struc:
310 a.a.
308 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.27  - L-lactate dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: (S)-lactate + NAD+ = pyruvate + NADH
(S)-lactate
+
NAD(+)
Bound ligand (Het Group name = NAD)
corresponds exactly
= pyruvate
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     oxidation-reduction process   4 terms 
  Biochemical function     catalytic activity     4 terms