PDBsum entry: 2e2w

Ligase

PDB id: 2e2w

Contents

Protein chain

113 a.a. *

* Residue conservation analysis

PDB id:

2e2w

Name:

Ligase

Title:

Solution structure of the first brct domain of human DNA ligase iv

Structure:

DNA ligase 4. Chain: a. Fragment: brct domain. Synonym: DNA ligase iv, polydeoxyribonucleotide synthase [atp] 4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lig4. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

T.Nagashima,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

T.Nagashima et al. Solution structure of the first brct domain of human DNA ligase V. To be published,

Date:

17-Nov-06 Release date: 05-Dec-06

Protein chain

P49917  (DNLI4_HUMAN) -  DNA ligase 4

Seq: 911 a.a.

Struc: 113 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.6.5.1.1 - Dna ligase (ATP).
• Reaction: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: intracellular (1 term)