PDBsum entry: 2e0t

Hydrolase

PDB id: 2e0t

Contents

Protein chain

150 a.a. *

Waters ×263

* Residue conservation analysis

PDB id:

2e0t

Name:

Hydrolase

Title:

Crystal structure of catalytic domain of dual specificity ph 26, ms0830 from homo sapiens

Structure:

Dual specificity phosphatase 26. Chain: a. Fragment: catalytic domain, residues 61-211. Synonym: ms0830, putative, low-molecular-mass dual- specifi phosphatase 4, dual-specificity phosphatase skrp3, mitogen- protein kinase phosphatase 8, nata1 protein, cdna flj31142 imr322001317, weakly similar to homo sapiens protein phosph engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: cell-free protein synthesis

Resolution:

1.67Å R-factor: 0.172 R-free: 0.212

Authors:

Y.Xie,S.Kishishita,K.Murayama,C.Hori-Takemoto,L.Chen,Z.J.Liu B.C.Wang,M.Shirozu,S.Yokoyama,Riken Structural Genomics/pro Initiative (Rsgi)

Key ref:

Y.Xie et al. Crystal structure of catalytic domain of dual specificity phosphatase 26, Ms0830 from homo sapiens. To be published,

Date:

13-Oct-06 Release date: 16-Oct-07

Protein chain

Q9BV47  (DUS26_HUMAN) -  Dual specificity protein phosphatase 26

Seq: 211 a.a.

Struc: 150 a.a.

Enzyme reactions

• Enzyme class 2: E.C.3.1.3.16 - Phosphoprotein phosphatase.
• Reaction: A phosphoprotein + H₂O = a protein + phosphate
• Enzyme class 3: E.C.3.1.3.48 - Protein-tyrosine-phosphatase.
• Reaction: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: dephosphorylation (2 terms)
• Biochemical function: phosphatase activity (3 terms)