spacer
spacer

PDBsum entry 2dzw

Go to PDB code: 
protein Protein-protein interface(s) links
Lyase PDB id
2dzw
Jmol
Contents
Protein chains
244 a.a. *
Waters ×430
* Residue conservation analysis
PDB id:
2dzw
Name: Lyase
Title: Structure of mutant tryptophan synthase alpha-subunit (e244a) from a hyperthermophile, pyrococcus furiosus
Structure: Tryptophan synthase alpha chain. Chain: a, b. Synonym: tryptophan synthase alpha-subunit. Engineered: yes. Mutation: yes
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.40Å     R-factor:   0.192     R-free:   0.258
Authors: K.Ogasahara,Y.Yamagata,K.Yutani,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: K.Ogasahara et al. Structures of mutant tryptophan synthase alpha-Subunits from a hyperthermophile, Pyrococcus furiosus. To be published, .
Date:
30-Sep-06     Release date:   28-Aug-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q8U094  (TRPA_PYRFU) -  Tryptophan synthase alpha chain
Seq:
Struc:
248 a.a.
244 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.20  - Tryptophan synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Tryptophan Biosynthesis
      Reaction: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
L-serine
+ 1-C-(indol-3-yl)glycerol 3-phosphate
= L-tryptophan
+ D-glyceraldehyde 3-phosphate
+ H(2)O
      Cofactor: Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   5 terms 
  Biochemical function     catalytic activity     3 terms