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PDBsum entry 2dx0

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
2dx0
Jmol
Contents
Protein chains
117 a.a. *
95 a.a. *
Ligands
SO4 ×3
Waters ×102
* Residue conservation analysis
PDB id:
2dx0
Name: Hydrolase
Title: Crystal structure of the n-terminal sh2 domain of mouse phospholipasE C-gamma 2
Structure: PhospholipasE C, gamma 2. Chain: a, b. Fragment: n-terminal sh2 domain, residues 516-640. Engineered: yes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: cell-free protein synthesis.
Resolution:
2.50Å     R-factor:   0.222     R-free:   0.262
Authors: N.Handa,T.Takagi,K.Murayama,T.Terada,M.Shirouzu,S.Yokoyama, Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: T.Takagi et al. Crystal structure of the n-Terminal sh2 domain of mouse phospholipase c-Gamma 2. To be published, .
Date:
22-Aug-06     Release date:   04-Sep-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8CIH5  (PLCG2_MOUSE) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1265 a.a.
117 a.a.
Protein chain
Pfam   ArchSchema ?
Q8CIH5  (PLCG2_MOUSE) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1265 a.a.
95 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.3.1.4.11  - Phosphoinositide phospholipase C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
myo-Inositol Phosphate Metabolism
      Reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
+ H(2)O
= 1D-myo-inositol 1,4,5-trisphosphate
+ diacylglycerol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     intracellular signal transduction   2 terms 
  Biochemical function     phosphatidylinositol phospholipase C activity     1 term