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PDBsum entry 2duv

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protein ligands links
Transferase PDB id
2duv
Jmol
Contents
Protein chain
272 a.a. *
Ligands
371
Waters ×74
* Residue conservation analysis
PDB id:
2duv
Name: Transferase
Title: Structure of cdk2 with a 3-hydroxychromones
Structure: Cell division protein kinase 2. Chain: a. Synonym: p33 protein kinase. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.20Å     R-factor:   0.264     R-free:   0.310
Authors: K.H.Kim,J.Lee,T.Park,S.Jeong,C.Hong
Key ref: J.Lee et al. (2007). 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett, 17, 1284-1287. PubMed id: 17178224 DOI: 10.1016/j.bmcl.2006.12.011
Date:
27-Jul-06     Release date:   27-Jan-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
272 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   14 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2006.12.011 Bioorg Med Chem Lett 17:1284-1287 (2007)
PubMed id: 17178224  
 
 
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
J.Lee, T.Park, S.Jeong, K.H.Kim, C.Hong.
 
  ABSTRACT  
 
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.