PDBsum entry: 2d8d

Isomerase

PDB id: 2d8d

Contents

Protein chains

80 a.a. *

Metals

_CL

Waters ×329

* Residue conservation analysis

PDB id:

2d8d

Name:

Isomerase

Title:

Structure of chorismate mutase (form i) from thermus thermop

Structure:

Phospho-2-dehydro-3-deoxyheptonate aldolase/chori mutase. Chain: a, b. Synonym: aroag. Engineered: yes

Source:

Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: aroag. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Dimer (from PQS)

Resolution:

1.15Å R-factor: 0.213 R-free: 0.219

Authors:

B.Bagautdinov,N.Kunishima,Riken Structural Genomics/proteomi Initiative (Rsgi)

Key ref:

B.Bagautdinov and n.kunishima Structure of chorismate mutase from thermus thermophilus hb8. To be published,

Date:

02-Dec-05 Release date: 02-Jun-06

Protein chains

Q72LN8  (Q72LN8_THET2) -  Phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase

Seq: 355 a.a.

Struc: 80 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase.
• Pathway: Shikimate and Chorismate Biosynthesis
• Reaction: Phosphoenolpyruvate + D-erythrose 4-phosphate + H₂O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate + phosphate
• Enzyme class 2: E.C.5.4.99.5 - Chorismate mutase.

Pathway:

• Reaction: Chorismate = prephenate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: chorismate metabolic process (1 term)