PDBsum entry: 2d7u

Ligase

PDB id: 2d7u

Contents

Protein chain

321 a.a. *

Waters ×106

* Residue conservation analysis

PDB id:

2d7u

Name:

Ligase

Title:

Crystal structure of hypothetical adenylosuccinate synthetas from pyrococcus horikoshii ot3

Structure:

Adenylosuccinate synthetase. Chain: a. Synonym: imp--aspartate ligase, adss, ampsase. Engineered: yes

Source:

Pyrococcus horikoshii. Organism_taxid: 70601. Strain: ot3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Dimer (from PQS)

Resolution:

2.50Å R-factor: 0.236 R-free: 0.285

Authors:

Y.Xie,S.Kishisita,K.Murayama,M.Shirouzu,S.Yokoyama,Riken Str Genomics/proteomics Initiative (Rsgi)

Key ref:

Y.Xie et al. Crystal structure of hypothetical adenylosuccinate synthetase, Ph0438 from pyrococcus horikoshii ot3. To be published,

Date:

29-Nov-05 Release date: 29-May-06

Protein chain

O58187  (PURA_PYRHO) -  Adenylosuccinate synthetase

Seq: 339 a.a.

Struc: 321 a.a.

Enzyme reactions

• Enzyme class: E.C.6.3.4.4 - Adenylosuccinate synthase.
• Pathway: AMP and GMP Biosynthesis
• Reaction: GTP + IMP + L-aspartate = GDP + phosphate + N₆-(1,2-dicarboxyethyl)- AMP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (1 term)
• Biological process: purine nucleotide biosynthetic process (1 term)
• Biochemical function: nucleotide binding (6 terms)