PDBsum entry 2cuc

Signaling protein

PDB id: 2cuc

Contents

Protein chain

70 a.a. *

* Residue conservation analysis

PDB id:

2cuc

Name:

Signaling protein

Title:

Solution structure of the sh3 domain of the mouse hypothetical protein sh3rf2

Structure:

Sh3 domain containing ring finger 2. Chain: a. Fragment: sh3 domain. Synonym: hypothetical sh3rf2 protein. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: sh3rf2. Other_details: cell-free system

NMR struc:

20 models

Authors:

S.Ohnishi,T.Kigawa,S.Koshiba,M.Inoue,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

S.Ohnishi et al. Solution structure of the sh3 domain of the mouse hypothetical protein sh3rf2. To be published, .

Date:

26-May-05 Release date: 26-Nov-05

Protein chain

Q8BZT2  (SH3R2_MOUSE) -  E3 ubiquitin-protein ligase SH3RF2 from Mus musculus

Seq: 735 a.a.

Struc: 70 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine