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PDBsum entry 2cr9

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protein links
Transferase PDB id
2cr9
Jmol
Contents
Protein chain
139 a.a. *
* Residue conservation analysis
PDB id:
2cr9
Name: Transferase
Title: Solution structure of wgr domain of poly(adp-ribose) polymerase-1
Structure: Poly [adp-ribose] polymerase-1. Chain: a. Fragment: wgr domain. Synonym: parp-1, adprt, NAD+, adp-ribosyltransferase-1, poly[adp-ribose] synthetase-1. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Other_details: cell-free protein synthesis
NMR struc: 20 models
Authors: T.Nagashima,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: T.Nagashima et al. Solution structure of wgr domain of poly(adp-Ribose) polymerase-1. To be published, .
Date:
20-May-05     Release date:   20-Nov-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P09874  (PARP1_HUMAN) -  Poly [ADP-ribose] polymerase 1
Seq:
Struc:
 
Seq:
Struc:
1014 a.a.
139 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 13 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.4.2.30  - NAD(+) ADP-ribosyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
NAD+ ADP-ribosyltransferase
      Reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor
NAD(+)
+ (ADP-D-ribosyl)(n)-acceptor
= nicotinamide
+ (ADP-D- ribosyl)(n+1)-acceptor
Molecule diagrams generated from .mol files obtained from the KEGG ftp site