PDBsum entry: 2cok

Transferase

PDB id: 2cok

Contents

Protein chain

113 a.a. *

* Residue conservation analysis

PDB id:

2cok

Name:

Transferase

Title:

Solution structure of brct domain of poly(adp-ribose) polymerase-1

Structure:

Poly [adp-ribose] polymerase-1. Chain: a. Fragment: brca1 c-turminus (brct) domain. Synonym: parp-1, adprt, NAD(+) adp-ribosyltransferase-1, poly[adp-ribose] synthetase-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

T.Nagashima,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

T.Nagashima et al. Solution structure of brct domain of poly(adp-Ribose) polymerase-1. To be published,

Date:

17-May-05 Release date: 17-Nov-05

Protein chain

P09874  (PARP1_HUMAN) -  Poly [ADP-ribose] polymerase 1

Seq: 1014 a.a.

Struc: 113 a.a.*

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.4.2.30 - NAD(+) ADP-ribosyltransferase.
• Pathway: NAD⁺ ADP-ribosyltransferase
• Reaction: NAD⁺ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: intracellular (1 term)