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PDBsum entry 2cmj

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2cmj
Jmol
Contents
Protein chains
410 a.a. *
Ligands
NAP ×2
Waters ×599
* Residue conservation analysis
PDB id:
2cmj
Name: Oxidoreductase
Title: Crystal structure of mouse cytosolic isocitrate dehydrogenase
Structure: Isocitrate dehydrogenase [nadp] cytoplasmic. Chain: a, b. Fragment: residues 4-413. Synonym: oxalosuccinate decarboxylase, idh, NADP(+)-specific icdh, idp. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: de3
Resolution:
1.99Å     R-factor:   0.196     R-free:   0.245
Authors: H.J.Cho,K.J.Kim,T.L.Huh,B.S.Kang
Key ref: H.J.Cho et al. Crystal structure of mouse cytosolic isocitrate dehydrogenase. To be published, .
Date:
10-May-06     Release date:   29-May-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
O88844  (IDHC_MOUSE) -  Isocitrate dehydrogenase [NADP] cytoplasmic
Seq:
Struc:
414 a.a.
410 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.42  - Isocitrate dehydrogenase (NADP(+)).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Citric acid cycle
      Reaction: Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH
Isocitrate
+
NADP(+)
Bound ligand (Het Group name = NAP)
corresponds exactly
= 2-oxoglutarate
+ CO(2)
+ NADPH
      Cofactor: Mn(2+) or Mg(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   5 terms 
  Biological process     oxidation-reduction process   10 terms 
  Biochemical function     oxidoreductase activity     9 terms