PDBsum entry: 2cka

Hydrolase

PDB id: 2cka

Contents

Protein chain

58 a.a. *

* Residue conservation analysis

PDB id:

2cka

Name:

Hydrolase

Title:

Solution structures of the brk domains of the human chromo helicase domain 7 and 8, reveals structural similarity with gyf domain suggesting a role in protein interaction

Structure:

Chromodomain-helicase-DNA-binding protein 8. Chain: a. Fragment: brk domain, residues 2012-2085. Synonym: atp-dependent helicase chd8, chd-8, helicase with snf2 domain 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta. Other_details: self made cdna library of multiple human carcinoma cell lines

NMR struc:

20 models

Authors:

E.Ab,R.N.De Jong,T.Diercks,J.Xiaoyun,M.Daniels,R.Kaptein, G.E.Folkers

Key ref:

E.Ab et al. Solution structures of the brk domains of the human chromo helicase domain 7 and 8, Reveals structural similarity with gyf domain suggesting a role in protein interaction. To be published,

Date:

14-Apr-06 Release date: 08-May-07

Protein chain

Q9HCK8  (CHD8_HUMAN) -  Chromodomain-helicase-DNA-binding protein 8

Seq: 2581 a.a.

Struc: 58 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.12 - Dna helicase.
• Reaction: ATP + H₂O = ADP + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site