spacer
spacer

PDBsum entry 2cbu

Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Hydrolase PDB id
2cbu
Jmol
Contents
Protein chains
440 a.a. *
Ligands
CTS ×2
ACT ×2
Metals
_CA
Waters ×824
* Residue conservation analysis
PDB id:
2cbu
Name: Hydrolase
Title: Beta-glucosidase from thermotoga maritima in complex with castanospermine
Structure: Beta-glucosidase a. Chain: a, b. Synonym: gentiobiase, cellobiase, beta-d-glucoside glucohydrolase. Engineered: yes
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
1.85Å     R-factor:   0.186     R-free:   0.237
Authors: T.M.Gloster,G.J.Davies,R.Madsen
Key ref: T.M.Gloster et al. (2006). Dissection of conformationally restricted inhibitors binding to a beta-glucosidase. Chembiochem, 7, 738-742. PubMed id: 16628756 DOI: 10.1002/cbic.200600005
Date:
09-Jan-06     Release date:   03-Feb-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q08638  (BGLA_THEMA) -  Beta-glucosidase A
Seq:
Struc:
446 a.a.
440 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.2.1.21  - Beta-glucosidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   4 terms 
  Biochemical function     hydrolase activity     4 terms  

 

 
DOI no: 10.1002/cbic.200600005 Chembiochem 7:738-742 (2006)
PubMed id: 16628756  
 
 
Dissection of conformationally restricted inhibitors binding to a beta-glucosidase.
T.M.Gloster, R.Madsen, G.J.Davies.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20490603 J.R.Ketudat Cairns, and A.Esen (2010).
β-Glucosidases.
  Cell Mol Life Sci, 67, 3389-3405.  
20066263 T.M.Gloster, and G.J.Davies (2010).
Glycosidase inhibition: assessing mimicry of the transition state.
  Org Biomol Chem, 8, 305-320.  
19532990 M.Aguilar-Moncayo, T.M.Gloster, J.P.Turkenburg, M.I.García-Moreno, C.Ortiz Mellet, G.J.Davies, and J.M.García Fernández (2009).
Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.
  Org Biomol Chem, 7, 2738-2747.
PDB codes: 2wbg 2wc3 2wc4
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

spacer

spacer