 |
PDBsum entry 2c9h
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Structure of mitochondrial beta-ketoacyl synthase
|
|
Structure:
|
|
Mitochondrial beta-ketoacyl synthase. Chain: a. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3.
|
|
Biol. unit:
|
|
Dimer (from PDB file)
|
|
Resolution:
|
|
|
1.80Å
|
R-factor:
|
0.181
|
R-free:
|
0.240
|
|
|
Authors:
|
|
G.Bunkoczi,X.Wu,C.Smee,O.Gileadi,C.Arrowsmith,A.Edwards,M.Sundstrom, J.Weigelt,F.Von Delft,U.Oppermann
|
|
Key ref:
|
|
G.Bunkoczi
et al.
Structure of mitochondrial beta-Ketoacyl synthase.
To be published,
.
|
|
|
Date:
|
|
|
12-Dec-05
|
Release date:
|
13-Dec-05
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q9NWU1
(OXSM_HUMAN) -
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
459 a.a.
427 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 7 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.3.1.41
- beta-ketoacyl-[acyl-carrier-protein] synthase I.
|
|
|
|
|
|
|
Reaction:
|
|
a fatty acyl-[ACP] + malonyl-[ACP] + H+ = a 3-oxoacyl-[ACP] + holo- [ACP] + CO2
|
|
|
|
|
|
fatty acyl-[ACP]
|
+
|
malonyl-[ACP]
|
+
|
H(+)
|
=
|
3-oxoacyl-[ACP]
|
+
|
holo- [ACP]
|
+
|
CO2
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
