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PDBsum entry 2c4a

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protein ligands metals links
Hydrolase PDB id
2c4a
Jmol
Contents
Protein chain
388 a.a. *
Ligands
SIA ×2
NAG-NAG ×2
NAG
BMA-MAN-MAN-MAN-
MAN-MAN-MAN
Metals
_CA
Waters ×259
* Residue conservation analysis
PDB id:
2c4a
Name: Hydrolase
Title: Structure of neuraminidase subtype n9 complexed with 30 mm sialic acid (nana, neu5ac), crystal soaked for 3 hours at 291 k.
Structure: Neuraminidase subtype n9. Chain: a. Fragment: residues 83-470. Engineered: yes
Source: Influenza a virus. Avian influenza virus a. Organism_taxid: 11320. Strain: a/tern/sterna albifrons/n9. Expressed in: gallus gallus. Expression_system_taxid: 9031
Resolution:
2.15Å     R-factor:   0.160     R-free:   0.205
Authors: E.Rudino-Pinera,P.Tunnah,S.J.Crennell,R.G.Webster,W.G.Laver, E.F.Garman
Key ref: E.Rudino-Pinera et al. The crystal structure of influenza type a virus neuraminidase of the n6 subtype at 1.85 a resolution. To be published, .
Date:
17-Oct-05     Release date:   27-Mar-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P03472  (NRAM_I75A5) -  Neuraminidase
Seq:
Struc:
470 a.a.
388 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.2.1.18  - Exo-alpha-sialidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   3 terms 
  Biological process     carbohydrate metabolic process   1 term 
  Biochemical function     exo-alpha-sialidase activity     1 term