PDBsum entry 2bcc

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Oxidoreductase PDB id
Protein chains
442 a.a. *
406 a.a. *
379 a.a. *
241 a.a. *
196 a.a. *
100 a.a. *
78 a.a. *
66 a.a. *
33 a.a. *
59 a.a. *
HEM ×3
PEE ×2
* Residue conservation analysis
PDB id:
Name: Oxidoreductase
Title: Stigmatellin-bound cytochrome bc1 complex from chicken
Structure: Ubiquinol cytochromE C oxidoreductase. Chain: a. Synonym: cytochrome bc1 complex, complex iii. Other_details: model include qo-site inhibitor stigmatellin ubiquinol cytochromE C oxidoreductase. Chain: b. Synonym: cytochrome bc1 complex, complex iii. Other_details: model include qo-site inhibitor stigmatellin ubiquinol cytochromE C oxidoreductase.
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Tissue: muscle. Organelle: mitochondria. Cellular_location: mitochondrial inner membrane. Other_details: isolated from tissue. Other_details: isolated from tissue
Biol. unit: Not given
3.50Å     R-factor:   0.284     R-free:   0.317
Authors: Z.Zhang,L.Huang,V.M.Shulmeister,Y.I.Chi,K.K.Kim,L.W.Hung,A.R E.A.Berry,S.H.Kim
Key ref:
Z.Zhang et al. (1998). Electron transfer by domain movement in cytochrome bc1. Nature, 392, 677-684. PubMed id: 9565029 DOI: 10.1038/33612
18-Sep-98     Release date:   02-Aug-99    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P31800  (QCR1_BOVIN) -  Cytochrome b-c1 complex subunit 1, mitochondrial
480 a.a.
442 a.a.*
Protein chain
Pfam   ArchSchema ?
P23004  (QCR2_BOVIN) -  Cytochrome b-c1 complex subunit 2, mitochondrial
453 a.a.
406 a.a.*
Protein chain
Pfam   ArchSchema ?
P18946  (CYB_CHICK) -  Cytochrome b
380 a.a.
379 a.a.
Protein chain
Pfam   ArchSchema ?
P00125  (CY1_BOVIN) -  Cytochrome c1, heme protein, mitochondrial
325 a.a.
241 a.a.*
Protein chain
Pfam   ArchSchema ?
P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial
274 a.a.
196 a.a.*
Protein chain
Pfam   ArchSchema ?
P00129  (QCR7_BOVIN) -  Cytochrome b-c1 complex subunit 7
111 a.a.
100 a.a.*
Protein chain
Pfam   ArchSchema ?
P13271  (QCR8_BOVIN) -  Cytochrome b-c1 complex subunit 8
82 a.a.
78 a.a.*
Protein chain
Pfam   ArchSchema ?
P00126  (QCR6_BOVIN) -  Cytochrome b-c1 complex subunit 6, mitochondrial
91 a.a.
66 a.a.*
Protein chain
No UniProt id for this chain
Struc: 33 a.a.
Protein chain
Pfam   ArchSchema ?
P00130  (QCR9_BOVIN) -  Cytochrome b-c1 complex subunit 9
64 a.a.
59 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 116 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain E: E.C.  - Quinol--cytochrome-c reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+
Bound ligand (Het Group name = BOG)
matches with 40.00% similarity
2 × ferricytochrome c
Bound ligand (Het Group name = HEM)
matches with 63.64% similarity
= quinone
+ 2 × ferrocytochrome c
+ 2 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   8 terms 
  Biological process     oxidation-reduction process   13 terms 
  Biochemical function     catalytic activity     10 terms  


    Added reference    
DOI no: 10.1038/33612 Nature 392:677-684 (1998)
PubMed id: 9565029  
Electron transfer by domain movement in cytochrome bc1.
Z.Zhang, L.Huang, V.M.Shulmeister, Y.I.Chi, K.K.Kim, L.W.Hung, A.R.Crofts, E.A.Berry, S.H.Kim.
The cytochrome bc1 is one of the three major respiratory enzyme complexes residing in the inner mitochondrial membrane. Cytochrome bc1 transfers electrons from ubiquinol to cytochrome c and uses the energy thus released to form an electrochemical gradient across the inner membrane. Our X-ray crystal structures of the complex from chicken, cow and rabbit in both the presence and absence of inhibitors of quinone oxidation, reveal two different locations for the extrinsic domain of one component of the enzyme, an iron-sulphur protein. One location is close enough to the supposed quinol oxidation site to allow reduction of the Fe-S protein by ubiquinol. The other site is close enough to cytochrome c1 to allow oxidation of the Fe-S protein by the cytochrome. As neither location will allow both reactions to proceed at a suitable rate, the reaction mechanism must involve movement of the extrinsic domain of the Fe-S component in order to shuttle electrons from ubiquinol to cytochrome c1. Such a mechanism has not previously been observed in redox protein complexes.
  Selected figure(s)  
Figure 3.
Figure 3 Structure of the intermembrane (external surface) domains of the chicken bc[1] complex. This is viewed from within the membrane, with the transmembrane helices truncated at roughly the membrane surface. Ball-and-stick models represent the haem group of cytochrome c[1], the Rieske iron-sulphur cluster, and the disulphide cysteines of subunit 8. SU, subunit; cyt, cytochrome.
Figure 6.
Figure 6 Relative positions of the redox centres in the two different conformations of the bc[1] complex dimer. a, b, Iron centres revealed by anomalous scattering near the iron edge. The net is a Bivoet difference map with X-ray wavelength 7,131 eV phased with experimental phases improved by averaging, and contoured at 4.5 . c, d, Schematic drawing representing the cofactors. a, c, Results from a native crystal, with the iron-sulphur cluster of the Rieske protein in the distal position (from the low-potential haem group of cytochrome b). b, d, Results from a crystal containing bound stigmatellin, with the cluster in the proximal position.
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (1998, 392, 677-684) copyright 1998.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

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A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization.
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20398779 B.Malyarchuk, M.Derenko, D.Berman, M.Perkova, T.Grzybowski, A.Lejrikh, and N.Bulakhova (2010).
Phylogeography and molecular adaptation of Siberian salamander Salamandrella keyserlingii based on mitochondrial DNA variation.
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20655344 D.W.Urry, K.D.Urry, W.Szaflarski, and M.Nowicki (2010).
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery.
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20025846 E.A.Berry, L.S.Huang, D.W.Lee, F.Daldal, K.Nagai, and N.Minagawa (2010).
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex.
  Biochim Biophys Acta, 1797, 360-370.
PDB code: 3h1l
20032466 E.L.Seifert, C.Estey, J.Y.Xuan, and M.E.Harper (2010).
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation.
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20091229 F.Baymann, and W.Nitschke (2010).
Heliobacterial Rieske/cytb complex.
  Photosynth Res, 104, 177-187.  
20496909 K.L.Hsueh, W.M.Westler, and J.L.Markley (2010).
NMR investigations of the Rieske protein from Thermus thermophilus support a coupled proton and electron transfer mechanism.
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19826804 K.McLuskey, A.W.Roszak, Y.Zhu, and N.W.Isaacs (2010).
Crystal structures of all-alpha type membrane proteins.
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19892700 M.Castellani, R.Covian, T.Kleinschroth, O.Anderka, B.Ludwig, and B.L.Trumpower (2010).
Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone reduction site.
  J Biol Chem, 285, 502-510.  
20217232 S.Lemeille, and J.D.Rochaix (2010).
State transitions at the crossroad of thylakoid signalling pathways.
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19431150 A.S.Walker, C.Auclair, M.Gredt, and P.Leroux (2009).
First occurrence of resistance to strobilurin fungicides in Microdochium nivale and Microdochium majus from French naturally infected wheat grains.
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19099453 D.R.Kolling, R.I.Samoilova, A.A.Shubin, A.R.Crofts, and S.A.Dikanov (2009).
Proton environment of reduced Rieske iron-sulfur cluster probed by two-dimensional ESEEM spectroscopy.
  J Phys Chem A, 113, 653-667.  
19348884 F.Millett, and B.Durham (2009).
Chapter 5 Use of ruthenium photooxidation techniques to study electron transfer in the cytochrome bc1 complex.
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20161522 H.B.Gray, and J.R.Winkler (2009).
Electron Flow through Proteins.
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19254042 J.W.Cooley, D.W.Lee, and F.Daldal (2009).
Across membrane communication between the Q(o) and Q(i) active sites of cytochrome bc(1).
  Biochemistry, 48, 1888-1899.  
19960681 L.Zhao, J.W.Pridgeon, J.J.Becnel, G.G.Clark, and K.J.Linthicum (2009).
Mitochondrial gene cytochrome b developmental and environmental expression in Aedes aegypti (Diptera: Culicidae).
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19719482 M.S.Albury, C.Elliott, and A.L.Moore (2009).
Towards a structural elucidation of the alternative oxidase in plants.
  Physiol Plant, 137, 316-327.  
19415898 M.Sarewicz, M.Dutka, W.Froncisz, and A.Osyczka (2009).
Magnetic interactions sense changes in distance between heme b(L) and the iron-sulfur cluster in cytochrome bc(1).
  Biochemistry, 48, 5708-5720.  
19165831 P.Van Nieuwenhuyse, T.Van Leeuwen, J.Khajehali, B.Vanholme, and L.Tirry (2009).
Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl.
  Pest Manag Sci, 65, 404-412.  
  19774111 Q.L.Chen, X.S.Tang, W.J.Yao, and S.Q.Lu (2009).
Bioinformatics analysis of the complete sequences of cytochrome b of Takydromus sylvaticus and modeling the tertiary structure of encoded protein.
  Int J Biol Sci, 5, 596-602.  
19176478 R.Covian, and B.L.Trumpower (2009).
Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers.
  J Biol Chem, 284, 8614-8620.  
19175316 R.E.Berry, M.N.Shokhirev, A.Y.Ho, F.Yang, T.K.Shokhireva, H.Zhang, A.Weichsel, W.R.Montfort, and F.A.Walker (2009).
Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.
  J Am Chem Soc, 131, 2313-2327.
PDB code: 3fll
19260761 S.Lemeille, A.Willig, N.Depège-Fargeix, C.Delessert, R.Bassi, and J.D.Rochaix (2009).
Analysis of the chloroplast protein kinase Stt7 during state transitions.
  PLoS Biol, 7, e45.  
19236481 V.Zara, L.Conte, and B.L.Trumpower (2009).
Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane.
  FEBS J, 276, 1900-1914.  
18796602 A.P.Komarov, O.W.Rokhlin, C.A.Yu, and A.V.Gudkov (2008).
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
  Proc Natl Acad Sci U S A, 105, 14453-14458.  
18501698 A.R.Crofts, J.T.Holland, D.Victoria, D.R.Kolling, S.A.Dikanov, R.Gilbreth, S.Lhee, R.Kuras, and M.G.Kuras (2008).
The Q-cycle reviewed: How well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric complex?
  Biochim Biophys Acta, 1777, 1001-1019.  
18701458 B.Gurung, L.Yu, and C.A.Yu (2008).
Stigmatellin Induces Reduction of Iron-Sulfur Protein in the Oxidized Cytochrome bc1 Complex.
  J Biol Chem, 283, 28087-28094.  
18247319 D.Fernández-Ortuño, J.A.Torés, Vicente, and A.Pérez-García (2008).
Field resistance to QoI fungicides in Podosphaera fusca is not supported by typical mutations in the mitochondrial cytochrome b gene.
  Pest Manag Sci, 64, 694-702.  
18953640 D.Xia, L.Esser, M.Elberry, F.Zhou, L.Yu, and C.A.Yu (2008).
The road to the crystal structure of the cytochrome bc (1) complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides.
  J Bioenerg Biomembr, 40, 485-492.  
18418633 E.A.Berry, and F.A.Walker (2008).
Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins.
  J Biol Inorg Chem, 13, 481-498.  
18022381 F.A.Rotsaert, M.G.Ding, and B.L.Trumpower (2008).
Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin.
  Biochim Biophys Acta, 1777, 211-219.  
18535145 G.J.Workun, K.Moquin, R.A.Rothery, and J.H.Weiner (2008).
Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold.
  Microbiol Mol Biol Rev, 72, 228.  
18258178 H.W.Ma, S.Yang, L.Yu, and C.A.Yu (2008).
Formation of engineered intersubunit disulfide bond in cytochrome bc1 complex disrupts electron transfer activity in the complex.
  Biochim Biophys Acta, 1777, 317-326.  
18039651 L.Esser, M.Elberry, F.Zhou, C.A.Yu, L.Yu, and D.Xia (2008).
Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides.
  J Biol Chem, 283, 2846-2857.
PDB codes: 2qjk 2qjp 2qjy
18533432 L.Zhao, J.W.Pridgeon, J.J.Becnel, G.G.Clark, and K.J.Linthicum (2008).
Cytochrome c gene and protein expression: developmental regulation, environmental response, and pesticide sensitivity in Aedes aegypti.
  J Med Entomol, 45, 401-408.  
18786405 M.V.Petoukhov, J.B.Vicente, P.B.Crowley, M.A.Carrondo, M.Teixeira, and D.I.Svergun (2008).
Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering.
  Structure, 16, 1428-1436.  
18093133 N.Fisher, and B.Meunier (2008).
Molecular basis of resistance to cytochrome bc1 inhibitors.
  FEMS Yeast Res, 8, 183-192.  
18516048 O.A.Ulanovskaya, J.Janjic, M.Suzuki, S.S.Sabharwal, P.T.Schumacker, S.J.Kron, and S.A.Kozmin (2008).
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
  Nat Chem Biol, 4, 418-424.  
18996700 P.J.Crowley, E.A.Berry, T.Cromartie, F.Daldal, C.R.Godfrey, D.W.Lee, J.E.Phillips, A.Taylor, and R.Viner (2008).
The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.
  Bioorg Med Chem, 16, 10345-10355.
PDB code: 3cwb
18454936 R.Covian, and B.L.Trumpower (2008).
The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.
  Biochim Biophys Acta, 1777, 1044-1052.  
18471987 R.Covian, and B.L.Trumpower (2008).
Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin.
  Biochim Biophys Acta, 1777, 1079-1091.  
18390544 S.R.Solmaz, and C.Hunte (2008).
Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.
  J Biol Chem, 283, 17542-17549.
PDB codes: 3cx5 3cxh
18713733 S.Yang, H.W.Ma, L.Yu, and C.A.Yu (2008).
On the Mechanism of Quinol Oxidation at the QP Site in the Cytochrome bc1 Complex: STUDIED USING MUTANTS LACKING CYTOCHROME bL OR bH.
  J Biol Chem, 283, 28767-28776.  
18721136 T.Kleinschroth, O.Anderka, M.Ritter, A.Stocker, T.A.Link, B.Ludwig, and P.Hellwig (2008).
Characterization of mutations in crucial residues around the Q(o) binding site of the cytochrome bc complex from Paracoccus denitrificans.
  FEBS J, 275, 4773-4785.  
17908308 A.Bresell, and B.Persson (2007).
Characterization of oligopeptide patterns in large protein sets.
  BMC Genomics, 8, 346.  
  18978960 A.R.Crofts (2007).
Life, Information, Entropy, and Time: Vehicles for Semantic Inheritance.
  Complexity, 13, 14-50.  
17200733 A.Y.Mulkidjanian (2007).
Proton translocation by the cytochrome bc1 complexes of phototrophic bacteria: introducing the activated Q-cycle.
  Photochem Photobiol Sci, 6, 19-34.  
17223530 D.J.Kolling, J.S.Brunzelle, S.Lhee, A.R.Crofts, and S.K.Nair (2007).
Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters.
  Structure, 15, 29-38.
PDB codes: 2nuk 2num 2nve 2nvf 2nvg 2nwf
17457691 D.Xia, L.Esser, L.Yu, and C.A.Yu (2007).
Structural basis for the mechanism of electron bifurcation at the quinol oxidation site of the cytochrome bc1 complex.
  Photosynth Res, 92, 17-34.  
17498743 E.Yamashita, H.Zhang, and W.A.Cramer (2007).
Structure of the cytochrome b6f complex: quinone analogue inhibitors as ligands of heme cn.
  J Mol Biol, 370, 39-52.
PDB codes: 2e74 2e75 2e76
17322303 J.Heinemeyer, H.P.Braun, E.J.Boekema, and R.Kouril (2007).
A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria.
  J Biol Chem, 282, 12240-12248.  
17174478 J.J.Perry, L.Fan, and J.A.Tainer (2007).
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
  Neuroscience, 145, 1280-1299.  
17360398 J.Zhu, T.Egawa, S.R.Yeh, L.Yu, and C.A.Yu (2007).
Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex.
  Proc Natl Acad Sci U S A, 104, 4864-4869.  
17573435 L.Giachini, F.Francia, G.Veronesi, D.W.Lee, F.Daldal, L.S.Huang, E.A.Berry, T.Cocco, S.Papa, F.Boscherini, and G.Venturoli (2007).
X-Ray absorption studies of Zn2+ binding sites in bacterial, avian, and bovine cytochrome bc1 complexes.
  Biophys J, 93, 2934-2951.  
17237510 M.S.Chae, C.C.Lin, K.E.Kessler, C.E.Nargang, L.L.Tanton, L.B.Hahn, and F.E.Nargang (2007).
Identification of an alternative oxidase induction motif in the promoter region of the aod-1 gene in Neurospora crassa.
  Genetics, 175, 1597-1606.  
17584742 R.Covian, K.Zwicker, F.A.Rotsaert, and B.L.Trumpower (2007).
Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex. Consequences for semiquinone stabilization.
  J Biol Chem, 282, 24198-24208.  
17561507 R.Covian, T.Kleinschroth, B.Ludwig, and B.L.Trumpower (2007).
Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites.
  J Biol Chem, 282, 22289-22297.  
17535914 R.Kuras, D.Saint-Marcoux, F.A.Wollman, and Vitry (2007).
A specific c-type cytochrome maturation system is required for oxygenic photosynthesis.
  Proc Natl Acad Sci U S A, 104, 9906-9910.  
17616531 S.A.Dikanov, J.T.Holland, B.Endeward, D.R.Kolling, R.I.Samoilova, T.F.Prisner, and A.R.Crofts (2007).
Hydrogen bonds between nitrogen donors and the semiquinone in the Qi-site of the bc1 complex.
  J Biol Chem, 282, 25831-25841.  
17516628 S.Devanathan, Z.Salamon, G.Tollin, J.C.Fitch, T.E.Meyer, E.A.Berry, and M.A.Cusanovich (2007).
Plasmon waveguide resonance spectroscopic evidence for differential binding of oxidized and reduced Rhodobacter capsulatus cytochrome c2 to the cytochrome bc1 complex mediated by the conformation of the Rieske iron-sulfur protein.
  Biochemistry, 46, 7138-7145.  
17253777 S.Rajagukguk, S.Yang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2007).
Effect of mutations in the cytochrome b ef loop on the electron-transfer reactions of the Rieske iron-sulfur protein in the cytochrome bc1 complex.
  Biochemistry, 46, 1791-1798.  
17399709 V.P.Shinkarev, and C.A.Wraight (2007).
Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes.
  FEBS Lett, 581, 1535-1541.  
17680808 V.Zara, L.Conte, and B.L.Trumpower (2007).
Identification and characterization of cytochrome bc(1) subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc(1) subunits.
  FEBS J, 274, 4526-4539.  
17848555 Y.R.Chen, C.L.Chen, D.R.Pfeiffer, and J.L.Zweier (2007).
Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.
  J Biol Chem, 282, 32640-32654.  
16624922 C.S.Willett (2006).
Deleterious epistatic interactions between electron transport system protein-coding loci in the copepod Tigriopus californicus.
  Genetics, 173, 1465-1477.  
16844750 E.J.Haddadian, and E.L.Gross (2006).
A Brownian dynamics study of the interactions of the luminal domains of the cytochrome b6f complex with plastocyanin and cytochrome c6: the effects of the Rieske FeS protein on the interactions.
  Biophys J, 91, 2589-2600.  
16551638 E.Schäfer, H.Seelert, N.H.Reifschneider, F.Krause, N.A.Dencher, and J.Vonck (2006).
Architecture of active mammalian respiratory chain supercomplexes.
  J Biol Chem, 281, 15370-15375.  
16586113 F.A.Walker (2006).
The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography.
  J Biol Inorg Chem, 11, 391-397.  
17008316 I.Forquer, R.Covian, M.K.Bowman, B.L.Trumpower, and D.M.Kramer (2006).
Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex.
  J Biol Chem, 281, 38459-38465.  
16987314 J.Bachmann, B.Bauer, K.Zwicker, B.Ludwig, and O.Anderka (2006).
The Rieske protein from Paracoccus denitrificans is inserted into the cytoplasmic membrane by the twin-arginine translocase.
  FEBS J, 273, 4817-4830.  
16352458 J.L.Cape, M.K.Bowman, and D.M.Kramer (2006).
Understanding the cytochrome bc complexes by what they don't do. The Q-cycle at 30.
  Trends Plant Sci, 11, 46-55.  
16371475 J.Yan, G.Kurisu, and W.A.Cramer (2006).
Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex.
  Proc Natl Acad Sci U S A, 103, 69-74.
PDB code: 2d2c
17050691 J.Zhang, F.E.Frerman, and J.J.Kim (2006).
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool.
  Proc Natl Acad Sci U S A, 103, 16212-16217.
PDB codes: 2gmh 2gmj
16924113 L.Esser, X.Gong, S.Yang, L.Yu, C.A.Yu, and D.Xia (2006).
Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex.
  Proc Natl Acad Sci U S A, 103, 13045-13050.
PDB codes: 2fyn 2fyu
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Regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex.
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15894632 J.N.Forkey, M.E.Quinlan, and Y.E.Goldman (2005).
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Keilin, cytochrome, and the respiratory chain.
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Microbial ferric iron reductases.
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Crystal structure of the bromide-bound D85S mutant of bacteriorhodopsin: principles of ion pumping.
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PDB code: 1mgy
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Superoxide and hydrogen peroxide production by Drosophila mitochondria.
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Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.
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Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5.
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Structures and proton-pumping strategies of mitochondrial respiratory enzymes.
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KAI1, a prostate metastasis suppressor: prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell-surface receptor proteins.
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Modeling of the structural features of integral-membrane proteins reverse-environment prediction of integral membrane protein structure (REPIMPS).
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Q-band ENDOR (electron nuclear double resonance) of the high-affinity ubisemiquinone center in cytochrome bo3 from Escherichia coli.
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Inhibitory copper binding site on the spinach cytochrome b6f complex: implications for Qo site catalysis.
  Biochemistry, 39, 3285-3296.  
10681499 B.Schoepp, E.Chabaud, C.Breyton, A.Verméglio, and J.L.Popot (2000).
On the spatial organization of hemes and chlorophyll in cytochrome b(6)f. A linear and circular dichroism study.
  J Biol Chem, 275, 5275-5283.  
10681500 B.Schoepp, J.Breton, P.Parot, and A.Verméglio (2000).
Relative orientation of the hemes of the cytochrome bc(1) complexes from Rhodobacter sphaeroides, Rhodospirillum rubrum, and beef heart mitochondria. A linear dichroism study.
  J Biol Chem, 275, 5284-5290.  
10788423 C.Breyton (2000).
Conformational changes in the cytochrome b6f complex induced by inhibitor binding.
  J Biol Chem, 275, 13195-13201.  
11004464 C.Breyton (2000).
The cytochrome b(6)f complex: structural studies and comparison with the bc(1) complex.
  Biochim Biophys Acta, 1459, 467-474.  
10788468 C.H.Snyder, E.B.Gutierrez-Cirlos, and B.L.Trumpower (2000).
Evidence for a concerted mechanism of ubiquinol oxidation by the cytochrome bc1 complex.
  J Biol Chem, 275, 13535-13541.  
10873857 C.Hunte, J.Koepke, C.Lange, T.Rossmanith, and H.Michel (2000).
Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.
  Structure, 8, 669-684.
PDB code: 1ezv
11074596 C.M.Perks, C.McCaig, and J.M.Holly (2000).
Differential insulin-like growth factor (IGF)-independent interactions of IGF binding protein-3 and IGF binding protein-5 on apoptosis in human breast cancer cells. Involvement of the mitochondria.
  J Cell Biochem, 80, 248-258.  
10632712 C.Schwarze, A.V.Carluccio, G.Venturoli, and A.Labahn (2000).
Photo-induced cyclic electron transfer involving cytochrome bc1 complex and reaction center in the obligate aerobic phototroph Roseobacter denitrificans.
  Eur J Biochem, 267, 422-433.  
11106766 D.A.Berthold, M.E.Andersson, and P.Nordlund (2000).
New insight into the structure and function of the alternative oxidase.
  Biochim Biophys Acta, 1460, 241-254.  
10966481 E.A.Berry, M.Guergova-Kuras, L.S.Huang, and A.R.Crofts (2000).
Structure and function of cytochrome bc complexes.
  Annu Rev Biochem, 69, 1005-1075.  
11004461 E.A.Berry, Z.Zhang, H.D.Bellamy, and L.Huang (2000).
Crystallographic location of two Zn(2+)-binding sites in the avian cytochrome bc(1) complex.
  Biochim Biophys Acta, 1459, 440-448.
PDB code: 3h1k
10781061 E.Darrouzet, M.Valkova-Valchanova, C.C.Moser, P.L.Dutton, and F.Daldal (2000).
Uncovering the [2Fe2S] domain movement in cytochrome bc1 and its implications for energy conversion.
  Proc Natl Acad Sci U S A, 97, 4567-4572.  
11112533 E.Darrouzet, M.Valkova-Valchanova, and F.Daldal (2000).
Probing the role of the Fe-S subunit hinge region during Q(o) site catalysis in Rhodobacter capsulatus bc(1) complex.
  Biochemistry, 39, 15475-15483.  
10734109 H.Tian, R.Sadoski, L.Zhang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2000).
Definition of the interaction domain for cytochrome c on the cytochrome bc(1) complex. Steady-state and rapid kinetic analysis of electron transfer between cytochrome c and Rhodobacter sphaeroides cytochrome bc(1) surface mutants.
  J Biol Chem, 275, 9587-9595.  
10971589 J.H.Nett, C.Hunte, and B.L.Trumpower (2000).
Changes to the length of the flexible linker region of the Rieske protein impair the interaction of ubiquinol with the cytochrome bc1 complex.
  Eur J Biochem, 267, 5777-5782.  
10837495 J.Illerhaus, L.Altschmied, J.Reichert, E.Zak, R.G.Herrmann, and W.Haehnel (2000).
Dynamic interaction of plastocyanin with the cytochrome bf complex.
  J Biol Chem, 275, 17590-17595.  
10966478 J.L.Popot, and D.M.Engelman (2000).
Helical membrane protein folding, stability, and evolution.
  Annu Rev Biochem, 69, 881-922.  
11101297 J.M.Shifman, B.R.Gibney, R.E.Sharp, and P.L.Dutton (2000).
Heme redox potential control in de novo designed four-alpha-helix bundle proteins.
  Biochemistry, 39, 14813-14821.  
10627300 K.C.Hansen, B.E.Schultz, G.Wang, and S.I.Chan (2000).
Reaction of Escherichia coli cytochrome bo(3) and mitochondrial cytochrome bc(1) with a photoreleasable decylubiquinol.
  Biochim Biophys Acta, 1456, 121-137.  
11112550 K.Kobayashi, S.Tagawa, and T.Mogi (2000).
Transient formation of ubisemiquinone radical and subsequent electron transfer process in the Escherichia coli cytochrome bo.
  Biochemistry, 39, 15620-15625.  
10852722 L.A.Sazanov, S.Y.Peak-Chew, I.M.Fearnley, and J.E.Walker (2000).
Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme.
  Biochemistry, 39, 7229-7235.  
10713075 L.Zhang, C.H.Tai, L.Yu, and C.A.Yu (2000).
pH-induced intramolecular electron transfer between the iron-sulfur protein and cytochrome c(1) in bovine cytochrome bc(1) complex.
  J Biol Chem, 275, 7656-7661.  
10681446 M.Brugna, S.Rodgers, A.Schricker, G.Montoya, M.Kazmeier, W.Nitschke, and I.Sinning (2000).
A spectroscopic method for observing the domain movement of the Rieske iron-sulfur protein.
  Proc Natl Acad Sci U S A, 97, 2069-2074.  
10823938 M.Eilers, S.C.Shekar, T.Shieh, S.O.Smith, and P.J.Fleming (2000).
Internal packing of helical membrane proteins.
  Proc Natl Acad Sci U S A, 97, 5796-5801.  
10858292 M.Guergova-Kuras, R.Kuras, N.Ugulava, I.Hadad, and A.R.Crofts (2000).
Specific mutagenesis of the rieske iron-sulfur protein in Rhodobacter sphaeroides shows that both the thermodynamic gradient and the pK of the oxidized form determine the rate of quinol oxidation by the bc(1) complex.
  Biochemistry, 39, 7436-7444.  
11093219 M.H.Huynh, P.S.White, and T.J.Meyer (2000).
Proton-Coupled Electron Transfer from Sulfur: A S-H/S-D Kinetic Isotope Effect of >/=31.1 We are grateful to the U.S. Department of Energy for financial support.
  Angew Chem Int Ed Engl, 39, 4101-4104.  
10898682 M.Korsinczky, N.Chen, B.Kotecka, A.Saul, K.Rieckmann, and Q.Cheng (2000).
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.
  Antimicrob Agents Chemother, 44, 2100-2108.  
11079541 M.Rana, Coo, F.Diaz, H.Smeets, and C.T.Moraes (2000).
An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production.
  Ann Neurol, 48, 774-781.  
11056038 M.Suwa, H.T.Yudate, Y.Masuho, and S.Mitaku (2000).
A novel measure characterized by a polar energy surface approximation for recognition and classification of transmembrane protein structures.
  Proteins, 41, 504-517.  
11112534 M.Valkova-Valchanova, E.Darrouzet, C.R.Moomaw, C.A.Slaughter, and F.Daldal (2000).
Proteolytic cleavage of the Fe-S subunit hinge region of Rhodobacter capsulatus bc(1) complex: effects of inhibitors and mutations.
  Biochemistry, 39, 15484-15492.  
10757970 R.C.Sadoski, G.Engstrom, H.Tian, L.Zhang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2000).
Use of a photoactivated ruthenium dimer complex to measure electron transfer between the Rieske iron-sulfur protein and cytochrome c(1) in the cytochrome bc(1) complex.
  Biochemistry, 39, 4231-4236.  
10704220 S.Heimann, M.V.Ponamarev, and W.A.Cramer (2000).
Movement of the Rieske iron-sulfur protein in the p-side bulk aqueous phase: effect of lumenal viscosity on redox reactions of the cytochrome b6f complex.
  Biochemistry, 39, 2692-2699.  
10861933 S.Jiang, and I.A.Vakser (2000).
Side chains in transmembrane helices are shorter at helix-helix interfaces.
  Proteins, 40, 429-435.  
10848994 S.Rodgers, C.Moser, M.Martinez-Julvez, and I.Sinning (2000).
Deletion of the 6-kDa subunit affects the activity and yield of the bc1 complex from Rhodovulum sulfidophilum.
  Eur J Biochem, 267, 3753-3761.  
10981634 T.M.Iverson, C.Luna-Chavez, I.Schröder, G.Cecchini, and D.C.Rees (2000).
Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex.
  Curr Opin Struct Biol, 10, 448-455.  
10673443 T.Ohnishi, C.C.Moser, C.C.Page, P.L.Dutton, and T.Yano (2000).
Simple redox-linked proton-transfer design: new insights from structures of quinol-fumarate reductase.
  Structure, 8, R23-R32.  
10733991 U.A.van der Heide, S.C.Hopkins, and Y.E.Goldman (2000).
A maximum entropy analysis of protein orientations using fluorescence polarization data from multiple probes.
  Biophys J, 78, 2138-2150.  
10692548 V.H.Obungu, Y.Wang, S.M.Amyot, C.B.Gocke, and D.S.Beattie (2000).
Mutations in the tether region of the iron-sulfur protein affect the activity and assembly of the cytochrome bc(1) complex of yeast mitochondria.
  Biochim Biophys Acta, 1457, 36-44.  
11123950 V.P.Shinkarev, N.B.Ugulava, A.R.Crofts, and C.A.Wraight (2000).
DCCD inhibits the reactions of the iron-sulfur protein in Rhodobacter sphaeroides chromatophores.
  Biochemistry, 39, 16206-16212.  
11087372 V.P.Shinkarev, N.B.Ugulava, E.Takahashi, A.R.Crofts, and C.A.Wraight (2000).
Aspartate-187 of cytochrome b is not needed for DCCD inhibition of ubiquinol: cytochrome c oxidoreductase in Rhodobacter sphaeroides chromatophores.
  Biochemistry, 39, 14232-14237.  
10869174 Y.I.Chi, L.S.Huang, Z.Zhang, J.G.Fernández-Velasco, and E.A.Berry (2000).
X-ray structure of a truncated form of cytochrome f from chlamydomonas reinhardtii.
  Biochemistry, 39, 7689-7701.
PDB code: 1cfm
10092604 A.Matsuno-Yagi, and Y.Hatefi (1999).
Ubiquinol:cytochrome c oxidoreductase. Effects of inhibitors on reverse electron transfer from the iron-sulfur protein to cytochrome b.
  J Biol Chem, 274, 9283-9288.  
10468555 A.R.Crofts, S.Hong, N.Ugulava, B.Barquera, R.Gennis, M.Guergova-Kuras, and E.A.Berry (1999).
Pathways for proton release during ubihydroquinone oxidation by the bc(1) complex.
  Proc Natl Acad Sci U S A, 96, 10021-10026.  
  10464208 A.S.Saribas, S.Mandaci, and F.Daldal (1999).
An engineered cytochrome b6c1 complex with a split cytochrome b is able to support photosynthetic growth of Rhodobacter capsulatus.
  J Bacteriol, 181, 5365-5372.  
10413476 B.Gomez, and N.C.Robinson (1999).
Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1.
  Biochemistry, 38, 9031-9038.  
  10493590 B.R.Gibney, and P.L.Dutton (1999).
Histidine placement in de novo-designed heme proteins.
  Protein Sci, 8, 1888-1898.  
  10416021 C.A.Yu, L.Zhang, K.P.Deng, H.Tian, D.Xia, H.Kim, J.Deisenhofer, and L.Yu (1999).
Structure and reaction mechanisms of multifunctional mitochondrial cytochrome bc1 complex.
  Biofactors, 9, 103-109.  
10531315 C.H.Snyder, and B.L.Trumpower (1999).
Ubiquinone at center N is responsible for triphasic reduction of cytochrome b in the cytochrome bc(1) complex.
  J Biol Chem, 274, 31209-31216.  
10082790 C.H.Snyder, E.Denke, and B.L.Trumpower (1999).
Aromatic amino acids in the Rieske iron-sulfur protein do not form an obligatory conduit for electron transfer from the iron-sulfur cluster to the heme of cytochrome c1 in the cytochrome bc1 complex.
  Biochim Biophys Acta, 1410, 237-247.  
9927413 C.Jungas, J.L.Ranck, J.L.Rigaud, P.Joliot, and A.Verméglio (1999).
Supramolecular organization of the photosynthetic apparatus of Rhodobacter sphaeroides.
  EMBO J, 18, 534-542.  
10508156 C.M.Cruciat, K.Hell, H.Fölsch, W.Neupert, and R.A.Stuart (1999).
Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex.
  EMBO J, 18, 5226-5233.  
10433117 Vitry, and O.Vallon (1999).
Mutants of Chlamydomonas: tools to study thylakoid membrane structure, function and biogenesis.
  Biochimie, 81, 631-643.  
10387032 E.Darrouzet, S.Mandaci, J.Li, H.Qin, D.B.Knaff, and F.Daldal (1999).
Substitution of the sixth axial ligand of Rhodobacter capsulatus cytochrome c1 heme yields novel cytochrome c1 variants with unusual properties.
  Biochemistry, 38, 7908-7917.  
10082948 F.Gao, H.Qin, D.B.Knaff, L.Zhang, L.Yu, C.A.Yu, K.A.Gray, F.Daldal, and M.R.Ondrias (1999).
Q-Band resonance Raman investigation of turnip cytochrome f and Rhodobacter capsulatus cytochrome c1.
  Biochim Biophys Acta, 1430, 203-213.  
10357809 F.Zito, G.Finazzi, R.Delosme, W.Nitschke, D.Picot, and F.A.Wollman (1999).
The Qo site of cytochrome b6f complexes controls the activation of the LHCII kinase.
  EMBO J, 18, 2961-2969.  
10092855 G.Montoya, K.te Kaat, S.Rodgers, W.Nitschke, and I.Sinning (1999).
The cytochrome bc1 complex from Rhodovulum sulfidophilum is a dimer with six quinones per monomer and an additional 6-kDa component.
  Eur J Biochem, 259, 709-718.  
  10477309 G.Schäfer, M.Engelhard, and V.Müller (1999).
Bioenergetics of the Archaea.
  Microbiol Mol Biol Rev, 63, 570-620.  
10066773 H.Tian, S.White, L.Yu, and C.A.Yu (1999).
Evidence for the head domain movement of the rieske iron-sulfur protein in electron transfer reaction of the cytochrome bc1 complex.
  J Biol Chem, 274, 7146-7152.  
9880536 H.Zhang, D.Huang, and W.A.Cramer (1999).
Stoichiometrically bound beta-carotene in the cytochrome b6f complex of oxygenic photosynthesis protects against oxygen damage.
  J Biol Chem, 274, 1581-1587.  
10447880 I.K.Srivastava, J.M.Morrisey, E.Darrouzet, F.Daldal, and A.B.Vaidya (1999).
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites.
  Mol Microbiol, 33, 704-711.  
9915790 J.G.Okun, P.Lümmen, and U.Brandt (1999).
Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).
  J Biol Chem, 274, 2625-2630.  
10092599 J.H.Nett, and B.L.Trumpower (1999).
Intermediate length Rieske iron-sulfur protein is present and functionally active in the cytochrome bc1 complex of Saccharomyces cerevisiae.
  J Biol Chem, 274, 9253-9257.  
10404600 J.Lubkowski, F.Hennecke, A.Plückthun, and A.Wlodawer (1999).
Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.
  Structure, 7, 711-722.
PDB code: 1tol
  10631987 J.U.Bowie (1999).
Helix-bundle membrane protein fold templates.
  Protein Sci, 8, 2711-2719.  
10611277 K.E.McAuley, P.K.Fyfe, J.P.Ridge, N.W.Isaacs, R.J.Cogdell, and M.R.Jones (1999).
Structural details of an interaction between cardiolipin and an integral membrane protein.
  Proc Natl Acad Sci U S A, 96, 14706-14711.
PDB code: 1qov
  10595562 K.S.Makarova, and N.V.Grishin (1999).
Thermolysin and mitochondrial processing peptidase: how far structure-functional convergence goes.
  Protein Sci, 8, 2537-2540.  
10358018 M.Brugna, W.Nitschke, M.Asso, B.Guigliarelli, D.Lemesle-Meunier, and C.Schmidt (1999).
Redox components of cytochrome bc-type enzymes in acidophilic prokaryotes. II. The Rieske protein of phylogenetically distant acidophilic organisms.
  J Biol Chem, 274, 16766-16772.  
9930987 M.M.Pereira, J.N.Carita, and M.Teixeira (1999).
Membrane-bound electron transfer chain of the thermohalophilic bacterium Rhodothermus marinus: a novel multihemic cytochrome bc, a new complex III.
  Biochemistry, 38, 1268-1275.  
10409625 Planque, J.A.Kruijtzer, R.M.Liskamp, D.Marsh, D.V.Greathouse, R.E.Koeppe, Kruijff, and J.A.Killian (1999).
Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptides.
  J Biol Chem, 274, 20839-20846.  
10066163 M.Saraste (1999).
Oxidative phosphorylation at the fin de siècle.
  Science, 283, 1488-1493.  
  10048323 Q.Zhao, S.Modi, G.Smith, M.Paine, P.D.McDonagh, C.R.Wolf, D.Tew, L.Y.Lian, G.C.Roberts, and H.P.Driessen (1999).
Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
  Protein Sci, 8, 298-306.
PDB code: 1b1c
10079091 R.E.Sharp, A.Palmitessa, B.R.Gibney, J.L.White, C.C.Moser, F.Daldal, and P.L.Dutton (1999).
Ubiquinone binding capacity of the Rhodobacter capsulatus cytochrome bc1 complex: effect of diphenylamine, a weak binding QO site inhibitor.
  Biochemistry, 38, 3440-3446.  
10555979 R.E.Sharp, B.R.Gibney, A.Palmitessa, J.L.White, J.A.Dixon, C.C.Moser, F.Daldal, and P.L.Dutton (1999).
Effect of inhibitors on the ubiquinone binding capacity of the primary energy conversion site in the Rhodobacter capsulatus cytochrome bc(1) complex.
  Biochemistry, 38, 14973-14980.  
10410805 S.H.White, and W.C.Wimley (1999).
Membrane protein folding and stability: physical principles.
  Annu Rev Biophys Biomol Struct, 28, 319-365.  
10567355 S.Hong, N.Ugulava, M.Guergova-Kuras, and A.R.Crofts (1999).
The energy landscape for ubihydroquinone oxidation at the Q(o) site of the bc(1) complex in Rhodobacter sphaeroides.
  J Biol Chem, 274, 33931-33944.  
10512801 S.Izrailev, A.R.Crofts, E.A.Berry, and K.Schulten (1999).
Steered molecular dynamics simulation of the Rieske subunit motion in the cytochrome bc(1) complex.
  Biophys J, 77, 1753-1768.  
10491129 S.van Wilpe, H.Boumans, G.Lobo-Hajdu, L.A.Grivell, and J.A.Berden (1999).
Functional complementation analysis of yeast bc1 mutants. A study of the mitochondrial import of heterologous and hybrid proteins.
  Eur J Biochem, 264, 825-832.  
10373012 T.J.Stevens, and I.T.Arkin (1999).
Are membrane proteins "inside-out" proteins?
  Proteins, 36, 135-143.  
10373108 T.M.Iverson, C.Luna-Chavez, G.Cecchini, and D.C.Rees (1999).
Structure of the Escherichia coli fumarate reductase respiratory complex.
  Science, 284, 1961-1966.
PDB code: 1fum
  10416020 U.Brandt (1999).
Proton translocation in the respiratory chain involving ubiquinone--a hypothetical semiquinone switch mechanism for complex I.
  Biofactors, 9, 95.  
10413471 V.Schünemann, A.X.Trautwein, J.Illerhaus, and W.Haehnel (1999).
Mössbauer and electron paramagnetic resonance studies of the cytochrome bf complex.
  Biochemistry, 38, 8981-8991.  
  10416018 W.A.Cramer, and G.M.Soriano (1999).
Energy transduction function of the quinone reactions in cytochrome bc complexes.
  Biofactors, 9, 81-86.  
9729743 A.R.Crofts, and E.A.Berry (1998).
Structure and function of the cytochrome bc1 complex of mitochondria and photosynthetic bacteria.
  Curr Opin Struct Biol, 8, 501-509.  
9609705 A.S.SaribaƟ, M.Valkova-Valchanova, M.K.Tokito, Z.Zhang, E.A.Berry, and F.Daldal (1998).
Interactions between the cytochrome b, cytochrome c1, and Fe-S protein subunits at the ubihydroquinone oxidation site of the bc1 complex of Rhodobacter capsulatus.
  Biochemistry, 37, 8105-8114.  
10066592 A.V.Vener, I.Ohad, and B.Andersson (1998).
Protein phosphorylation and redox sensing in chloroplast thylakoids.
  Curr Opin Plant Biol, 1, 217-223.  
9671508 F.Zito, G.Finazzi, P.Joliot, and F.A.Wollman (1998).
Glu78, from the conserved PEWY sequence of subunit IV, has a key function in cytochrome b6f turnover.
  Biochemistry, 37, 10395-10403.  
9653134 H.Kim, D.Xia, C.A.Yu, J.Z.Xia, A.M.Kachurin, L.Zhang, L.Yu, and J.Deisenhofer (1998).
Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bc1 complex from bovine heart.
  Proc Natl Acad Sci U S A, 95, 8026-8033.  
9724544 H.Oh-oka, M.Iwaki, and S.Itoh (1998).
Membrane-bound cytochrome cz couples quinol oxidoreductase to the P840 reaction center complex in isolated membranes of the green sulfur bacterium Chlorobium tepidum.
  Biochemistry, 37, 12293-12300.  
9774409 H.Tian, L.Yu, M.W.Mather, and C.A.Yu (1998).
Flexibility of the neck region of the rieske iron-sulfur protein is functionally important in the cytochrome bc1 complex.
  J Biol Chem, 273, 27953-27959.  
9699610 J.M.Grimes, and D.I.Stuart (1998).
Large unit cells and cellular mechanics.
  Nat Struct Biol, 5, 630-634.  
9843452 J.M.Shifman, C.C.Moser, W.A.Kalsbeck, D.F.Bocian, and P.L.Dutton (1998).
Functionalized de novo designed proteins: mechanism of proton coupling to oxidation/reduction in heme protein maquettes.
  Biochemistry, 37, 16815-16827.  
9819216 M.B.Valkova-Valchanova, A.S.Saribas, B.R.Gibney, P.L.Dutton, and F.Daldal (1998).
Isolation and characterization of a two-subunit cytochrome b-c1 subcomplex from Rhodobacter capsulatus and reconstitution of its ubihydroquinone oxidation (Qo) site with purified Fe-S protein subunit.
  Biochemistry, 37, 16242-16251.  
  9658021 M.Brugna, D.Albouy, and W.Nitschke (1998).
Diversity of cytochrome bc complexes: example of the Rieske protein in green sulfur bacteria.
  J Bacteriol, 180, 3719-3723.  
9784589 M.Hippler, K.Redding, and J.D.Rochaix (1998).
Chlamydomonas genetics, a tool for the study of bioenergetic pathways.
  Biochim Biophys Acta, 1367, 1.  
9751725 M.S.Graige, G.Feher, and M.Y.Okamura (1998).
Conformational gating of the electron transfer reaction QA-.QB --> QAQB-. in bacterial reaction centers of Rhodobacter sphaeroides determined by a driving force assay.
  Proc Natl Acad Sci U S A, 95, 11679-11684.  
9860833 M.V.Ponamarev, and W.A.Cramer (1998).
Perturbation of the internal water chain in cytochrome f of oxygenic photosynthesis: loss of the concerted reduction of cytochromes f and b6.
  Biochemistry, 37, 17199-17208.  
9671509 P.Joliot, and A.Joliot (1998).
In vivo analysis of the effect of dicyclohexylcarbodiimide on electron and proton transfers in cytochrome bf complex of Chlorella sorokiniana.
  Biochemistry, 37, 10404-10410.  
9819220 R.Kuras, M.Guergova-Kuras, and A.R.Crofts (1998).
Steps toward constructing a cytochrome b6 f complex in the purple bacterium Rhodobacter sphaeroides: an example of the structural plasticity of a membrane cytochrome.
  Biochemistry, 37, 16280-16288.  
9751640 R.M.Garavito (1998).
Membrane protein structures: the known world expands.
  Curr Opin Biotechnol, 9, 344-349.  
9651245 S.Iwata, J.W.Lee, K.Okada, J.K.Lee, M.Iwata, B.Rasmussen, T.A.Link, S.Ramaswamy, and B.K.Jap (1998).
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex.
  Science, 281, 64-71.
PDB codes: 1be3 1bgy
9705291 S.Jünemann, P.Heathcote, and P.R.Rich (1998).
On the mechanism of quinol oxidation in the bc1 complex.
  J Biol Chem, 273, 21603-21607.  
9693740 U.Brandt (1998).
The chemistry and mechanics of ubihydroquinone oxidation at center P (Qo) of the cytochrome bc1 complex.
  Biochim Biophys Acta, 1365, 261-268.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.