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PDBsum entry 2b35

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2b35
Jmol
Contents
Protein chains
(+ 0 more) 253 a.a. *
Ligands
TCL ×6
NAD ×6
* Residue conservation analysis
PDB id:
2b35
Name: Oxidoreductase
Title: Crystal structure of mycobacterium tuberculosis enoyl reductase (inha) inhibited by triclosan
Structure: Enoyl-[acyl-carrier-protein] reductase [nadh]. Chain: a, b, c, d, e, f. Synonym: nadh-dependent enoyl-acp reductase. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: inha. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Tetramer (from PDB file)
Resolution:
2.30Å     R-factor:   0.268     R-free:   0.334
Authors: T.J.Sullivan,J.J.Truglio,P.Novichenok,C.Stratton,X.Zhang, T.Kaur,F.Johnson,M.S.Boyne,A.Amin
Key ref: T.J.Sullivan et al. (2006). Acs chem.Biol., 1, 43-53.
Date:
19-Sep-05     Release date:   07-Mar-06    
PROCHECK
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 Headers
 References

Protein chains
Pfam  
P9WGR1  (INHA_MYCTU) -  Enoyl-[acyl-carrier-protein] reductase [NADH]
Seq:
Struc:
269 a.a.
253 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.3.1.9  - Enoyl-[acyl-carrier-protein] reductase (NADH).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH
acyl-[acyl-carrier protein]
+
NAD(+)
Bound ligand (Het Group name = NAD)
corresponds exactly
= trans-2,3-dehydroacyl-[acyl- carrier protein]
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell wall   2 terms 
  Biological process     oxidation-reduction process   5 terms 
  Biochemical function     oxidoreductase activity     2 terms