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PDBsum entry 2ak4

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protein metals Protein-protein interface(s) links
Immune system PDB id
2ak4
Jmol
Contents
Protein chains
276 a.a. *
99 a.a. *
13 a.a. *
204 a.a. *
241 a.a. *
Metals
IOD ×22
Waters ×239
* Residue conservation analysis
PDB id:
2ak4
Name: Immune system
Title: Crystal structure of sb27 tcr in complex with hla-b 3508- 13Mer peptide
Structure: Hla-b35 variant. Chain: a, f, k, q. Fragment: extracellular domains, alpha1,2,3. Engineered: yes. Beta-2-microglobulin. Chain: b, g, l, r. Engineered: yes. Ebv peptide lpeplpqgqltay. Chain: c, h, m, s.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide lpeplpqgqltay.
Biol. unit: Pentamer (from PQS)
Resolution:
2.50Å     R-factor:   0.247     R-free:   0.278
Authors: F.E.Tynan,S.R.Burrows,A.M.Buckle,C.S.Clements,N.A.Borg, J.J.Miles,T.Beddoe,J.C.Whisstock,M.C.Wilce,S.L.Silins, J.M.Burrows,L.Kjer-Nielsen,L.Konstenko,A.W.Purcell, J.Mccluskey,J.Rossjohn
Key ref:
F.E.Tynan et al. (2005). T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol, 6, 1114-1122. PubMed id: 16186824 DOI: 10.1038/ni1257
Date:
03-Aug-05     Release date:   11-Oct-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P30685  (1B35_HUMAN) -  HLA class I histocompatibility antigen, B-35 alpha chain
Seq:
Struc:
362 a.a.
276 a.a.*
Protein chains
Pfam   ArchSchema ?
P61769  (B2MG_HUMAN) -  Beta-2-microglobulin
Seq:
Struc:
119 a.a.
99 a.a.
Protein chains
Pfam   ArchSchema ?
P03206  (BZLF1_EBVB9) -  Trans-activator protein BZLF1
Seq:
Struc:
245 a.a.
13 a.a.
Protein chains
Pfam   ArchSchema ?
P01848  (TCA_HUMAN) -  T-cell receptor alpha chain C region
Seq:
Struc:
142 a.a.
204 a.a.*
Protein chains
Pfam   ArchSchema ?
P01850  (TRBC1_HUMAN) -  T-cell receptor beta-1 chain C region
Seq:
Struc:
177 a.a.
241 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 7 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   15 terms 
  Biological process     immune system process   21 terms 
  Biochemical function     protein binding     3 terms  

 

 
DOI no: 10.1038/ni1257 Nat Immunol 6:1114-1122 (2005)
PubMed id: 16186824  
 
 
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
F.E.Tynan, S.R.Burrows, A.M.Buckle, C.S.Clements, N.A.Borg, J.J.Miles, T.Beddoe, J.C.Whisstock, M.C.Wilce, S.L.Silins, J.M.Burrows, L.Kjer-Nielsen, L.Kostenko, A.W.Purcell, J.McCluskey, J.Rossjohn.
 
  ABSTRACT  
 
Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still preserving MHC restriction, we have determined here the structure of a TCR in complex with HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was atypical of TCR-peptide-MHC class I interactions, being dominated at the interface by peptide-mediated interactions. The TCR assumed two distinct orientations, swiveling on top of the centrally bulged, rigid peptide such that only limited contacts were made with MHC class I. Although the TCR-peptide recognition resembled an antibody-antigen interaction, the TCR-MHC class I contacts defined a minimal 'generic footprint' of MHC-restriction. Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction.
 
  Selected figure(s)  
 
Figure 2.
Figure 2. SB27 TCR contacts at the interface. (a) 'Footprint' of the SB27 TCR on the HLA-B^*3508-LPEP complex. There are limited MHC-mediated contacts with the SB27 TCR on the gray surface representation of the HLA-B^*3508 heavy chain. (b) 'Footprint' of the LC13 TCR in complex with HLA-B8-FLRGRAYGL, showing the focus toward the carboxy-terminal end of the peptide^5. (c) Closer view of the SB27 TCR contacts with the HLA-B^*3508-LPEP complex. HLA-B^*3508 -helices, light gray; peptide, orange; conformation of Gln155 as it appears in the binary complex (HLA-B^*3508-LPEP)3, dark gray; side chains from the triad of residues mediating MHC-restriction, gold. CDR loop colors are as in Figure 1b.
Figure 4.
Figure 4. SB27 TCR recognition of the HLA-B^*3508-LPEP complex is antibody like and is dominated by TCR-peptide interactions. (a,b) GRASP image of the SB27 TCR-peptide interaction (a) compared with that of a complex between an Fab and a peptide from human rhinovirus viral capsid protein VP2 (b; Protein Data Bank accession number, 1A3R)46. TCR V[ ]and Fab V[H], red; TCR V and Fab V[L], blue; Epstein-Barr virus LPEP and rhinovirus VP2 peptides, yellow. (c) Closer view of the SB27 TCR interactions with the solvent-exposed side chains of the LPEP peptide. Peptide, orange; CDR loop colors are as in Figure 1b. (d) Dose-response assays of analogs of the 13-residue peptide (LPEPLPQGQLTAY) that include single-amino acid substitutions, assessing recognition by SB27 CTLs (chromium-release assays, left) and binding to 'empty' HLA-B^*3508 with the transporter associated with antigen processing-deficient T2-B^*3508 (right). Peptides recognized well in the cytotoxicity assays are assumed to bind well to HLA-B^*3508 and are therefore excluded from the MHC-binding assays (NT). Data represent peptide concentrations for half-maximal lysis or binding calculated from dose-response curves for each peptide and are representative of two independent experiments with similar results.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nat Immunol (2005, 6, 1114-1122) copyright 2005.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21199956 D.K.Sethi, D.A.Schubert, A.K.Anders, A.Heroux, D.A.Bonsor, C.P.Thomas, E.J.Sundberg, J.Pyrdol, and K.W.Wucherpfennig (2011).
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
  J Exp Med, 208, 91.
PDB code: 3pl6
  21301479 J.J.Miles, D.C.Douek, and D.A.Price (2011).
Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.
  Immunol Cell Biol, 89, 375-387.  
21364947 J.M.Khan, and S.Ranganathan (2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
  PLoS One, 6, e17194.  
21127503 P.A.van der Merwe, and O.Dushek (2011).
Mechanisms for T cell receptor triggering.
  Nat Rev Immunol, 11, 47-55.  
  21301478 S.Gras, L.Kjer-Nielsen, Z.Chen, J.Rossjohn, and J.McCluskey (2011).
The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.
  Immunol Cell Biol, 89, 388-395.  
20212169 A.Theodossis, C.Guillonneau, A.Welland, L.K.Ely, C.S.Clements, N.A.Williamson, A.I.Webb, J.A.Wilce, R.J.Mulder, M.A.Dunstone, P.C.Doherty, J.McCluskey, A.W.Purcell, S.J.Turner, and J.Rossjohn (2010).
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.
  Proc Natl Acad Sci U S A, 107, 5534-5539.
PDB codes: 3l3d 3l3g 3l3h 3l3i 3l3j 3l3k
20616723 C.T.Spencer, P.Gilchuk, S.M.Dragovic, and S.Joyce (2010).
Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand.
  Curr Opin Organ Transplant, 15, 512-525.  
20639478 D.K.Cole, E.S.Edwards, K.K.Wynn, M.Clement, J.J.Miles, K.Ladell, J.Ekeruche, E.Gostick, K.J.Adams, A.Skowera, M.Peakman, L.Wooldridge, D.A.Price, and A.K.Sewell (2010).
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
  J Immunol, 185, 2600-2610.  
21067543 D.R.Flower, I.K.Macdonald, K.Ramakrishnan, M.N.Davies, and I.A.Doytchinova (2010).
Computer aided selection of candidate vaccine antigens.
  Immunome Res, 6, S1.  
21124993 J.J.Miles, A.M.Bulek, D.K.Cole, E.Gostick, A.J.Schauenburg, G.Dolton, V.Venturi, M.P.Davenport, M.P.Tan, S.R.Burrows, L.Wooldridge, D.A.Price, P.J.Rizkallah, and A.K.Sewell (2010).
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
  PLoS Pathog, 6, e1001198.
PDB code: 3o4l
20844028 J.Liu, P.Wu, F.Gao, J.Qi, A.Kawana-Tachikawa, J.Xie, C.J.Vavricka, A.Iwamoto, T.Li, and G.F.Gao (2010).
Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.
  J Virol, 84, 11849-11857.
PDB code: 3i6l
20190139 L.Wooldridge, M.Clement, A.Lissina, E.S.Edwards, K.Ladell, J.Ekeruche, R.E.Hewitt, B.Laugel, E.Gostick, D.K.Cole, R.Debets, C.Berrevoets, J.J.Miles, S.R.Burrows, D.A.Price, and A.K.Sewell (2010).
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
  J Immunol, 184, 3357-3366.  
20422411 M.J.Ciesielski, M.S.Ahluwalia, S.A.Munich, M.Orton, T.Barone, A.Chanan-Khan, and R.A.Fenstermaker (2010).
Antitumor cytotoxic T-cell response induced by a survivin peptide mimic.
  Cancer Immunol Immunother, 59, 1211-1221.  
20173027 N.Blanchard, T.Kanaseki, H.Escobar, F.Delebecque, N.A.Nagarajan, E.Reyes-Vargas, D.K.Crockett, D.H.Raulet, J.C.Delgado, and N.Shastri (2010).
Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.
  J Immunol, 184, 3033-3042.  
20707881 N.E.Elamin, C.Bade-Doeding, R.Blasczyk, and B.Eiz-Vesper (2010).
Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters the PΩ peptide motif.
  Tissue Antigens, 76, 487-490.  
20711359 S.A.Valkenburg, S.Gras, C.Guillonneau, N.L.La Gruta, P.G.Thomas, A.W.Purcell, J.Rossjohn, P.C.Doherty, S.J.Turner, and K.Kedzierska (2010).
Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.
  PLoS Pathog, 6, 0.
PDB code: 3ftg
20566715 S.Gras, Z.Chen, J.J.Miles, Y.C.Liu, M.J.Bell, L.C.Sullivan, L.Kjer-Nielsen, R.M.Brennan, J.M.Burrows, M.A.Neller, R.Khanna, A.W.Purcell, A.G.Brooks, J.McCluskey, J.Rossjohn, and S.R.Burrows (2010).
Allelic polymorphism in the T cell receptor and its impact on immune responses.
  J Exp Med, 207, 1555-1567.
PDB codes: 3mv7 3mv8 3mv9
20483993 S.R.Burrows, Z.Chen, J.K.Archbold, F.E.Tynan, T.Beddoe, L.Kjer-Nielsen, J.J.Miles, R.Khanna, D.J.Moss, Y.C.Liu, S.Gras, L.Kostenko, R.M.Brennan, C.S.Clements, A.G.Brooks, A.W.Purcell, J.McCluskey, and J.Rossjohn (2010).
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
  Proc Natl Acad Sci U S A, 107, 10608-10613.
PDB codes: 3kww 3kxf
20405119 Y.Fujii, T.Matsutani, K.Kitaura, S.Suzuki, T.Itoh, T.Takasaki, R.Suzuki, and I.Kurane (2010).
Comprehensive analysis and characterization of the TCR alpha chain sequences in the common marmoset.
  Immunogenetics, 62, 383-395.  
19605354 D.K.Cole, F.Yuan, P.J.Rizkallah, J.J.Miles, E.Gostick, D.A.Price, G.F.Gao, B.K.Jakobsen, and A.K.Sewell (2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
  J Biol Chem, 284, 27281-27289.
PDB code: 3hg1
19307587 G.Stewart-Jones, A.Wadle, A.Hombach, E.Shenderov, G.Held, E.Fischer, S.Kleber, F.Stenner-Liewen, S.Bauer, A.McMichael, A.Knuth, H.Abken, A.A.Hombach, V.Cerundolo, E.Y.Jones, and C.Renner (2009).
Rational development of high-affinity T-cell receptor-like antibodies.
  Proc Natl Acad Sci U S A, 106, 5784-5788.
PDB codes: 3gje 3gjf 3gjg 3hae
19139173 J.K.Archbold, W.A.Macdonald, S.Gras, L.K.Ely, J.J.Miles, M.J.Bell, R.M.Brennan, T.Beddoe, M.C.Wilce, C.S.Clements, A.W.Purcell, J.McCluskey, S.R.Burrows, and J.Rossjohn (2009).
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.
  J Exp Med, 206, 209-219.
PDB codes: 3dx6 3dx7 3dx8 3dx9 3dxa
19196958 J.Petersen, S.J.Wurzbacher, N.A.Williamson, S.H.Ramarathinam, H.H.Reid, A.K.Nair, A.Y.Zhao, R.Nastovska, G.Rudge, J.Rossjohn, and A.W.Purcell (2009).
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
  Proc Natl Acad Sci U S A, 106, 2776-2781.
PDB codes: 3fqn 3fqr 3fqt 3fqu 3fqw 3fqx
19148199 K.C.Garcia, J.J.Adams, D.Feng, and L.K.Ely (2009).
The molecular basis of TCR germline bias for MHC is surprisingly simple.
  Nat Immunol, 10, 143-147.  
19416894 K.Rubtsova, J.P.Scott-Browne, F.Crawford, S.Dai, P.Marrack, and J.W.Kappler (2009).
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
  Proc Natl Acad Sci U S A, 106, 7951-7956.  
  19177349 P.Kumar, A.Vahedi-Faridi, W.Saenger, A.Ziegler, and B.Uchanska-Ziegler (2009).
Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.
  Protein Sci, 18, 37-49.
PDB code: 3bo8
19617632 P.Kumar, A.Vahedi-Faridi, W.Saenger, E.Merino, J.A.López de Castro, B.Uchanska-Ziegler, and A.Ziegler (2009).
Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens.
  J Biol Chem, 284, 29784-29797.
PDB codes: 3bp4 3bp7 3bvn 3bxn
19464197 T.Beddoe, Z.Chen, C.S.Clements, L.K.Ely, S.R.Bushell, J.P.Vivian, L.Kjer-Nielsen, S.S.Pang, M.A.Dunstone, Y.C.Liu, W.A.Macdonald, M.A.Perugini, M.C.Wilce, S.R.Burrows, A.W.Purcell, T.Tiganis, S.P.Bottomley, J.McCluskey, and J.Rossjohn (2009).
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
  Immunity, 30, 777-788.  
20064448 W.A.Macdonald, Z.Chen, S.Gras, J.K.Archbold, F.E.Tynan, C.S.Clements, M.Bharadwaj, L.Kjer-Nielsen, P.M.Saunders, M.C.Wilce, F.Crawford, B.Stadinsky, D.Jackson, A.G.Brooks, A.W.Purcell, J.W.Kappler, S.R.Burrows, J.Rossjohn, and J.McCluskey (2009).
T cell allorecognition via molecular mimicry.
  Immunity, 31, 897-908.
PDB codes: 3kpl 3kpm 3kpn 3kpo 3kpp 3kpq 3kpr 3kps
19472182 Y.Chen, Y.Shi, H.Cheng, Y.Q.An, and G.F.Gao (2009).
Structural immunology and crystallography help immunologists see the immune system in action: how T and NK cells touch their ligands.
  IUBMB Life, 61, 579-590.  
18342005 D.I.Godfrey, J.Rossjohn, and J.McCluskey (2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
  Immunity, 28, 304-314.  
18726714 E.J.Collins, and D.S.Riddle (2008).
TCR-MHC docking orientation: natural selection, or thymic selection?
  Immunol Res, 41, 267-294.  
18332182 E.J.Petrie, C.S.Clements, J.Lin, L.C.Sullivan, D.Johnson, T.Huyton, A.Heroux, H.L.Hoare, T.Beddoe, H.H.Reid, M.C.Wilce, A.G.Brooks, and J.Rossjohn (2008).
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.
  J Exp Med, 205, 725-735.
PDB code: 3cdg
18193023 H.Watarai, R.Nakagawa, M.Omori-Miyake, N.Dashtsoodol, and M.Taniguchi (2008).
Methods for detection, isolation and culture of mouse and human invariant NKT cells.
  Nat Protoc, 3, 70-78.  
18275829 J.Ishizuka, G.B.Stewart-Jones, A.van der Merwe, J.I.Bell, A.J.McMichael, and E.Y.Jones (2008).
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
  Immunity, 28, 171-182.
PDB codes: 2vlj 2vlk 2vll 2vlm 2vlr
18378495 J.K.Archbold, W.A.Macdonald, S.R.Burrows, J.Rossjohn, and J.McCluskey (2008).
T-cell allorecognition: a case of mistaken identity or déjà vu?
  Trends Immunol, 29, 220-226.  
18270323 K.K.Wynn, Z.Fulton, L.Cooper, S.L.Silins, S.Gras, J.K.Archbold, F.E.Tynan, J.J.Miles, J.McCluskey, S.R.Burrows, J.Rossjohn, and R.Khanna (2008).
Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.
  Blood, 111, 4283-4292.
PDB codes: 3bw9 3bwa
19047637 K.Kedzierska, C.Guillonneau, S.Gras, L.A.Hatton, R.Webby, A.W.Purcell, J.Rossjohn, P.C.Doherty, and S.J.Turner (2008).
Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy.
  Proc Natl Acad Sci U S A, 105, 19408-19413.
PDB code: 3cpl
17719639 K.Kedzierska, N.L.La Gruta, J.Stambas, S.J.Turner, and P.C.Doherty (2008).
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
  Mol Immunol, 45, 607-618.  
18678247 L.K.Ely, S.R.Burrows, A.W.Purcell, J.Rossjohn, and J.McCluskey (2008).
T-cells behaving badly: structural insights into alloreactivity and autoimmunity.
  Curr Opin Immunol, 20, 575-580.  
18384692 M.Chiriva-Internati, R.Ferraro, M.Prabhakar, Y.Yu, L.Baggoni, J.Moreno, N.Gagliano, N.Portinaro, M.R.Jenkins, E.E.Frezza, F.Hardwicke, N.D'Cunha, W.Kast, and E.Cobos (2008).
The pituitary tumor transforming gene 1 (PTTG-1): an immunological target for multiple myeloma.
  J Transl Med, 6, 15.  
18243675 N.Blanchard, and N.Shastri (2008).
Coping with loss of perfection in the MHC class I peptide repertoire.
  Curr Opin Immunol, 20, 82-88.  
18304006 P.Marrack, J.P.Scott-Browne, S.Dai, L.Gapin, and J.W.Kappler (2008).
Evolutionarily conserved amino acids that control TCR-MHC interaction.
  Annu Rev Immunol, 26, 171-203.  
18207719 S.Gras, L.Kjer-Nielsen, S.R.Burrows, J.McCluskey, and J.Rossjohn (2008).
T-cell receptor bias and immunity.
  Curr Opin Immunol, 20, 119-125.  
18703505 T.Mareeva, E.Martinez-Hackert, and Y.Sykulev (2008).
How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide.
  J Biol Chem, 283, 29053-29059.
PDB codes: 3cvh 3cvi
18301425 V.Venturi, D.A.Price, D.C.Douek, and M.P.Davenport (2008).
The molecular basis for public T-cell responses?
  Nat Rev Immunol, 8, 231-238.  
17473845 A.W.Purcell, J.McCluskey, and J.Rossjohn (2007).
More than one reason to rethink the use of peptides in vaccine design.
  Nat Rev Drug Discov, 6, 404-414.  
17521918 C.Mazza, and B.Malissen (2007).
What guides MHC-restricted TCR recognition?
  Semin Immunol, 19, 225-235.  
17363906 C.Mazza, N.Auphan-Anezin, C.Gregoire, A.Guimezanes, C.Kellenberger, A.Roussel, A.Kearney, P.A.van der Merwe, A.M.Schmitt-Verhulst, and B.Malissen (2007).
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
  EMBO J, 26, 1972-1983.
PDB code: 2ol3
17694060 D.Feng, C.J.Bond, L.K.Ely, J.Maynard, and K.C.Garcia (2007).
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
  Nat Immunol, 8, 975-983.
PDB codes: 2pxy 2z31 2z35
17273992 E.Gostick, D.K.Cole, S.L.Hutchinson, L.Wooldridge, S.Tafuro, B.Laugel, A.Lissina, A.Oxenius, J.M.Boulter, D.A.Price, and A.K.Sewell (2007).
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
  Eur J Immunol, 37, 479-486.  
17259989 F.E.Tynan, H.H.Reid, L.Kjer-Nielsen, J.J.Miles, M.C.Wilce, L.Kostenko, N.A.Borg, N.A.Williamson, T.Beddoe, A.W.Purcell, S.R.Burrows, J.McCluskey, and J.Rossjohn (2007).
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
  Nat Immunol, 8, 268-276.
PDB codes: 2nw2 2nw3 2nx5
17128277 G.E.Hammer, F.Gonzalez, E.James, H.Nolla, and N.Shastri (2007).
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
  Nat Immunol, 8, 101-108.  
17611570 J.H.Kessler, and C.J.Melief (2007).
Identification of T-cell epitopes for cancer immunotherapy.
  Leukemia, 21, 1859-1874.  
17418777 J.Rossjohn, and J.McCluskey (2007).
How a home-grown T cell receptor interacts with a foreign landscape.
  Cell, 129, 19-20.  
17418792 L.A.Colf, A.J.Bankovich, N.A.Hanick, N.A.Bowerman, L.L.Jones, D.M.Kranz, and K.C.Garcia (2007).
How a single T cell receptor recognizes both self and foreign MHC.
  Cell, 129, 135-146.
PDB codes: 2e7l 2oi9
17950605 L.Deng, and R.A.Mariuzza (2007).
Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors.
  Trends Biochem Sci, 32, 500-508.  
17334368 L.Deng, R.J.Langley, P.H.Brown, G.Xu, L.Teng, Q.Wang, M.I.Gonzales, G.G.Callender, M.I.Nishimura, S.L.Topalian, and R.A.Mariuzza (2007).
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor.
  Nat Immunol, 8, 398-408.
PDB codes: 2ial 2iam 2ian
18083574 M.Koch, S.Camp, T.Collen, D.Avila, J.Salomonsen, H.J.Wallny, A.van Hateren, L.Hunt, J.P.Jacob, F.Johnston, D.A.Marston, I.Shaw, P.R.Dunbar, V.Cerundolo, E.Y.Jones, and J.Kaufman (2007).
Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
  Immunity, 27, 885-899.
PDB codes: 3bev 3bew
17581592 N.A.Borg, K.S.Wun, L.Kjer-Nielsen, M.C.Wilce, D.G.Pellicci, R.Koh, G.S.Besra, M.Bharadwaj, D.I.Godfrey, J.McCluskey, and J.Rossjohn (2007).
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.
  Nature, 448, 44-49.
PDB code: 2po6
18007679 N.J.Felix, and P.M.Allen (2007).
Specificity of T-cell alloreactivity.
  Nat Rev Immunol, 7, 942-953.  
17825839 P.J.Miller, Y.Pazy, B.Conti, D.Riddle, E.Appella, and E.J.Collins (2007).
Single MHC mutation eliminates enthalpy associated with T cell receptor binding.
  J Mol Biol, 373, 315-327.
PDB codes: 2j8u 2jcc 2uwe
17459926 R.M.Brennan, J.J.Miles, S.L.Silins, M.J.Bell, J.M.Burrows, and S.R.Burrows (2007).
Predictable alphabeta T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope.
  J Virol, 81, 7269-7273.  
17121793 X.G.Yu, M.Lichterfeld, S.Chetty, K.L.Williams, S.K.Mui, T.Miura, N.Frahm, M.E.Feeney, Y.Tang, F.Pereyra, M.X.Labute, K.Pfafferott, A.Leslie, H.Crawford, R.Allgaier, W.Hildebrand, R.Kaslow, C.Brander, T.M.Allen, E.S.Rosenberg, P.Kiepiela, M.Vajpayee, P.A.Goepfert, M.Altfeld, P.J.Goulder, and B.D.Walker (2007).
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
  J Virol, 81, 1619-1631.  
17389359 Y.Mimura, Y.Mimura-Kimura, K.Doores, D.Golgher, B.G.Davis, R.A.Dwek, P.M.Rudd, and T.Elliott (2007).
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.
  Proc Natl Acad Sci U S A, 104, 5983-5988.  
17011774 C.S.Clements, M.A.Dunstone, W.A.Macdonald, J.McCluskey, and J.Rossjohn (2006).
Specificity on a knife-edge: the alphabeta T cell receptor.
  Curr Opin Struct Biol, 16, 787-795.  
16474394 H.L.Hoare, L.C.Sullivan, G.Pietra, C.S.Clements, E.J.Lee, L.K.Ely, T.Beddoe, M.Falco, L.Kjer-Nielsen, H.H.Reid, J.McCluskey, L.Moretta, J.Rossjohn, and A.G.Brooks (2006).
Structural basis for a major histocompatibility complex class Ib-restricted T cell response.
  Nat Immunol, 7, 256-264.
PDB code: 2esv
16963442 J.K.Archbold, W.A.Macdonald, J.J.Miles, R.M.Brennan, L.Kjer-Nielsen, J.McCluskey, S.R.Burrows, and J.Rossjohn (2006).
Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry.
  J Biol Chem, 281, 34324-34332.
PDB code: 2h6p
20477094 K.Irvine, and J.Bennink (2006).
Factors influencing immunodominance hierarchies in TCD8+ -mediated antiviral responses.
  Expert Rev Clin Immunol, 2, 135-147.  
16860610 L.C.Sullivan, H.L.Hoare, J.McCluskey, J.Rossjohn, and A.G.Brooks (2006).
A structural perspective on MHC class Ib molecules in adaptive immunity.
  Trends Immunol, 27, 413-420.  
16617112 L.K.Ely, T.Beddoe, C.S.Clements, J.M.Matthews, A.W.Purcell, L.Kjer-Nielsen, J.McCluskey, and J.Rossjohn (2006).
Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.
  Proc Natl Acad Sci U S A, 103, 6641-6646.  
16505140 L.Kjer-Nielsen, N.A.Borg, D.G.Pellicci, T.Beddoe, L.Kostenko, C.S.Clements, N.A.Williamson, M.J.Smyth, G.S.Besra, H.H.Reid, M.Bharadwaj, D.I.Godfrey, J.Rossjohn, and J.McCluskey (2006).
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
  J Exp Med, 203, 661-673.
PDB codes: 2eyr 2eys 2eyt
16551255 M.G.Rudolph, R.L.Stanfield, and I.A.Wilson (2006).
How TCRs bind MHCs, peptides, and coreceptors.
  Annu Rev Immunol, 24, 419-466.  
17005729 N.A.Williamson, J.Rossjohn, and A.W.Purcell (2006).
Tumors reveal their secrets to cytotoxic T cells.
  Proc Natl Acad Sci U S A, 103, 14649-14650.  
17110956 S.J.Turner, P.C.Doherty, J.McCluskey, and J.Rossjohn (2006).
Structural determinants of T-cell receptor bias in immunity.
  Nat Rev Immunol, 6, 883-894.  
16297661 S.R.Burrows, J.Rossjohn, and J.McCluskey (2006).
Have we cut ourselves too short in mapping CTL epitopes?
  Trends Immunol, 27, 11-16.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.