PDBsum entry: 2ad7

Oxidoreductase

PDB id: 2ad7

Contents

Protein chains

571 a.a. *

69 a.a. *

Ligands

PQQ ×2

Metals

_CA ×2

Waters ×2060

* Residue conservation analysis

PDB id:

2ad7

Name:

Oxidoreductase

Title:

Crystal structure of methanol dehydrogenase from m. W3a1 (fo the presence of methanol

Structure:

Methanol dehydrogenase subunit 1. Chain: a, c. Synonym: mdh large alpha subunit, medh. Methanol dehydrogenase subunit 2. Chain: b, d. Synonym: mdh small beta subunit, mdh-associated peptide, me ec: 1.1.99.8

Source:

Methylophilus methylotrophus. Organism_taxid: 2327. Strain: w3a1. Strain: w3a1

Biol. unit:

Tetramer (from PQS)

Resolution:

1.50Å R-factor: 0.156 R-free: 0.177

Authors:

J.Li,J.-H.Gan,Z.-X.Xia,F.S.Mathews

Key ref:

J.Li et al. The enzymatic reaction-Induced configuration change of the prosthetic group pqq of methanol dehydrogenase. To be published,

Date:

20-Jul-05 Release date: 25-Jul-06

Protein chains

P38539  (DHM1_METME) -  Methanol dehydrogenase [cytochrome c] subunit 1

Seq: 573 a.a.

Struc: 571 a.a.

Protein chains

P38540  (DHM2_METME) -  Methanol dehydrogenase [cytochrome c] subunit 2

Seq: 91 a.a.

Struc: 69 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.1.1.2.7 - Methanol dehydrogenase (cytochrome c).
• Reaction: A primary alcohol + 2 cytochrome c(L) = an aldehyde + 2 reduced cytochrome c(L)
• Cofactor: Pyrroloquinoline quinone

Pyrroloquinoline quinone (Bound ligand (Het Group name = PQQ) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: membrane (3 terms)
• Biological process: oxidation-reduction process (3 terms)
• Biochemical function: oxidoreductase activity (5 terms)