spacer
spacer

PDBsum entry 2abu

Go to PDB code: 
protein metals links
Oxidoreductase PDB id
2abu
Jmol
Contents
Protein chain
662 a.a.
Metals
FE2
Theoretical model
PDB id:
2abu
Name: Oxidoreductase
Title: Human 12-lipoxygenase
Structure: Arachidonate 12-lipoxygenase, 12s-type. Chain: a. Synonym: 12-lox, platelet-type lipoxygenase 12. Ec: 1.13.11.31
Source: Homo sapiens. Human
Authors: P.Arul Prakasam,P.P.Mathur
Key ref: P.Arul prakasam and p.p.mathur Structure of human 12-Lipoxygenase. To be published, .
Date:
16-Jul-05     Release date:   02-Aug-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18054  (LOX12_HUMAN) -  Arachidonate 12-lipoxygenase, 12S-type
Seq:
Struc:
 
Seq:
Struc:
663 a.a.
662 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.13.11.31  - Arachidonate 12-lipoxygenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate
Arachidonate
+ O(2)
= (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate
      Cofactor: Fe cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site