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PDBsum entry 2x9f

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protein ligands metals links
Transferase PDB id
2x9f
Jmol
Contents
Protein chain
265 a.a. *
Ligands
X9F
Metals
_MG ×2
Waters ×249
* Residue conservation analysis
PDB id:
2x9f
Name: Transferase
Title: Ephb4 kinase domain inhibitor complex
Structure: Ephrin type-b receptor 4. Chain: a. Fragment: kinase domain, residues 598-899. Synonym: ephb4 receptor tyrosine kinase, tyrosine-protein k receptor htk, tyrosine-protein kinase tyro11. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Resolution:
1.75Å     R-factor:   0.158     R-free:   0.194
Authors: J.Read,C.A.Brassington,I.Green,E.J.Mccall,A.L.Valentine, D.B
Key ref: C.Bardelle et al. (2010). Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett, 20, 6242-6245. PubMed id: 20850301 DOI: 10.1016/j.bmcl.2010.08.100
Date:
17-Mar-10     Release date:   29-Sep-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P54760  (EPHB4_HUMAN) -  Ephrin type-B receptor 4
Seq:
Struc:
 
Seq:
Struc:
987 a.a.
265 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.10.1  - Receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP
+ [protein]-L-tyrosine
= ADP
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     regulation of signal transduction   2 terms 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     5 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2010.08.100 Bioorg Med Chem Lett 20:6242-6245 (2010)
PubMed id: 20850301  
 
 
Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors.
C.Bardelle, B.Barlaam, N.Brooks, T.Coleman, D.Cross, R.Ducray, I.Green, C.L.Brempt, A.Olivier, J.Read.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21441027 B.Barlaam, R.Ducray, C.Lambert-van der Brempt, P.Plé, C.Bardelle, N.Brooks, T.Coleman, D.Cross, J.G.Kettle, and J.Read (2011).
Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series.
  Bioorg Med Chem Lett, 21, 2207-2211.
PDB code: 2xvd
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