PDBsum entry 2li5

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Protein transport PDB id
Protein chains
117 a.a.
34 a.a.
PDB id:
Name: Protein transport
Title: Nmr structure of atg8-atg7c30 complex
Structure: Autophagy-related protein 8. Chain: a. Synonym: atg8, autophagy-related ubiquitin-like modifier at cytoplasm to vacuole targeting protein 5. Engineered: yes. Mutation: yes. Ubiquitin-like modifier-activating enzyme atg7. Chain: b. Fragment: unp residues 601-630.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: atg8, apg8, aut7, cvt5, ybl078c, ybl0732. Expressed in: aspergillus niger. Expression_system_taxid: 5061. Gene: atg7, apg7, cvt2, yhr171w. Expressed in: escherichia coli.
NMR struc: 19 models
Authors: H.Kumeta,K.Satoo,N.N.Noda,Y.Fujioka,K.Ogura,H.Nakatogawa,Y.O F.Inagaki
Key ref: N.N.Noda et al. (2011). Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell, 44, 462-475. PubMed id: 22055191 DOI: 10.1016/j.molcel.2011.08.035
23-Aug-11     Release date:   16-Nov-11    
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Protein chain
Pfam   ArchSchema ?
P38182  (ATG8_YEAST) -  Autophagy-related protein 8
117 a.a.
117 a.a.*
Protein chain
Pfam   ArchSchema ?
P38862  (ATG7_YEAST) -  Ubiquitin-like modifier-activating enzyme ATG7
630 a.a.
34 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   12 terms 
  Biological process     transport   12 terms 
  Biochemical function     protein tag     2 terms  


DOI no: 10.1016/j.molcel.2011.08.035 Mol Cell 44:462-475 (2011)
PubMed id: 22055191  
Structural basis of Atg8 activation by a homodimeric E1, Atg7.
N.N.Noda, K.Satoo, Y.Fujioka, H.Kumeta, K.Ogura, H.Nakatogawa, Y.Ohsumi, F.Inagaki.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
23142983 M.Yamaguchi, K.Matoba, R.Sawada, Y.Fujioka, H.Nakatogawa, H.Yamamoto, Y.Kobashigawa, H.Hoshida, R.Akada, Y.Ohsumi, N.N.Noda, and F.Inagaki (2012).
Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.
  Nat Struct Mol Biol, 19, 1250-1256.  
23142976 S.E.Kaiser, K.Mao, A.M.Taherbhoy, S.Yu, J.L.Olszewski, D.M.Duda, I.Kurinov, A.Deng, T.D.Fenn, D.J.Klionsky, and B.A.Schulman (2012).
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
  Nat Struct Mol Biol, 19, 1242-1249.
PDB codes: 4gsj 4gsk 4gsl
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