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PDBsum entry 2ig7

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protein ligands Protein-protein interface(s) links
Transferase PDB id
2ig7
Jmol
Contents
Protein chain
335 a.a. *
Ligands
UNX ×24
Waters ×252
* Residue conservation analysis
PDB id:
2ig7
Name: Transferase
Title: Crystal structure of human choline kinase b
Structure: Choline/ethanolamine kinase. Chain: a, b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chkb, chetk, chkl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
1.80Å     R-factor:   0.192     R-free:   0.227
Authors: W.M.Rabeh,W.Tempel,L.Nedyalkova,G.Wasney,R.Landry,M.Vedadi, C.H.Arrowsmith,A.M.Edwards,M.Sundstrom,J.Weigelt, A.Bochkarev,H.Park,Structural Genomics Consortium (Sgc)
Key ref: W.M.Rabeh et al. Crystal structure of human choline kinase b. To be published, .
Date:
22-Sep-06     Release date:   10-Oct-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9Y259  (CHKB_HUMAN) -  Choline/ethanolamine kinase
Seq:
Struc:
395 a.a.
335 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 1: E.C.2.7.1.32  - Choline kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + choline = ADP + phosphocholine
ATP
+ choline
= ADP
+ phosphocholine
   Enzyme class 2: E.C.2.7.1.82  - Ethanolamine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + ethanolamine = ADP + O-phosphoethanolamine
ATP
+ ethanolamine
= ADP
+ O-phosphoethanolamine
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytosol   1 term 
  Biological process     small molecule metabolic process   9 terms 
  Biochemical function     nucleotide binding     7 terms