spacer
spacer

PDBsum entry 1zx8

Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Unknown function PDB id
1zx8
Jmol
Contents
Protein chains
127 a.a. *
Ligands
1PE ×3
Metals
_NI
Waters ×243
* Residue conservation analysis
PDB id:
1zx8
Name: Unknown function
Title: Crystal structure of an atypical cyclophilin (peptidylprolyl isomerase) (tm1367) from thermotoga maritima at 1.90 a reso
Structure: Hypothetical protein tm1367. Chain: a, b, c. Engineered: yes
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1367. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.166     R-free:   0.210
Authors: Joint Center For Structural Genomics (Jcsg)
Key ref:
K.K.Jin et al. (2006). Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins, 63, 1112-1118. PubMed id: 16544291 DOI: 10.1002/prot.20894
Date:
07-Jun-05     Release date:   26-Jul-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9X187  (Q9X187_THEMA) -  DUF369 domain-containing protein
Seq:
Struc:
124 a.a.
127 a.a.
Key:    PfamA domain  Secondary structure

 

 
DOI no: 10.1002/prot.20894 Proteins 63:1112-1118 (2006)
PubMed id: 16544291  
 
 
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold.
K.K.Jin, S.S.Krishna, R.Schwarzenbacher, D.McMullan, P.Abdubek, S.Agarwalla, E.Ambing, H.Axelrod, J.M.Canaves, H.J.Chiu, A.M.Deacon, M.DiDonato, M.A.Elsliger, J.Feuerhelm, A.Godzik, C.Grittini, S.K.Grzechnik, J.Hale, E.Hampton, J.Haugen, M.Hornsby, L.Jaroszewski, H.E.Klock, M.W.Knuth, E.Koesema, A.Kreusch, P.Kuhn, S.A.Lesley, M.D.Miller, K.Moy, E.Nigoghossian, L.Okach, S.Oommachen, J.Paulsen, K.Quijano, R.Reyes, C.Rife, R.C.Stevens, G.Spraggon, H.van den Bedem, J.Velasquez, A.White, G.Wolf, G.W.Han, Q.Xu, K.O.Hodgson, J.Wooley, I.A.Wilson.
 
  ABSTRACT  
 
No abstract given.

 
  Selected figure(s)  
 
Figure 2.
Figure 2. A: Structural superposition of TM1367 (blue) and the human cyclophilin A (PDB: 2cpl, gray). Residues corresponding to the calcineurin binding site of human cyclophilin A are shown in ball-and-stick representation. B: Residues corresponding to PPlase active site of cyclophilin A are shown in ball-and-stick representation. TM1367 residues are shown in brackets.
Figure 3.
Figure 3. A: Structure of TM1367 with a PEG-200 molecule in the putative active site. Contact residues of chain B in a shell 4 Å from the PEG molecule are shown in ball-and-stick. B: Structural superposition of TM1367 (blue) and the C-terminal domain of a protein of unknown function from B. cereus (PDB: 1×7f, green), which is a seven- rather than eight-stranded, closed -barrel.
 
  The above figures are reprinted by permission from John Wiley & Sons, Inc.: Proteins (2006, 63, 1112-1118) copyright 2006.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
  20944235 B.Mohanty, P.Serrano, B.Pedrini, K.Jaudzems, M.Geralt, R.Horst, T.Herrmann, M.A.Elsliger, I.A.Wilson, and K.Wüthrich (2010).
Comparison of NMR and crystal structures for the proteins TM1112 and TM1367.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 66, 1381-1392.
PDB codes: 2k9z 2ka0
19465773 T.C.Terwilliger, P.D.Adams, R.J.Read, A.J.McCoy, N.W.Moriarty, R.W.Grosse-Kunstleve, P.V.Afonine, P.H.Zwart, and L.W.Hung (2009).
Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard.
  Acta Crystallogr D Biol Crystallogr, 65, 582-601.  
18073103 W.A.Hendrickson (2007).
Impact of structures from the protein structure initiative.
  Structure, 15, 1528-1529.  
17206469 X.Ai, A.Semesi, A.Yee, C.H.Arrowsmith, S.S.Li, and W.Y.Choy (2007).
Backbone and side chain 1H, 13C, and 15N resonance assignments of AF2241 from Archaeoglobus fulgidus.
  J Biomol NMR, 38, 183.  
17610131 X.Ai, L.Li, A.Semesi, A.Yee, C.H.Arrowsmith, S.S.Li, and W.Y.Choy (2007).
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold.
  J Biomol NMR, 38, 353-358.
PDB code: 2nnz
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.