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PDBsum entry 1zx0

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protein ligands Protein-protein interface(s) links
Transferase PDB id
1zx0
Jmol
Contents
Protein chains
229 a.a. *
Ligands
SAH ×4
Waters ×796
* Residue conservation analysis
Superseded by: 3orh
PDB id:
1zx0
Name: Transferase
Title: Human guanidinoacetate n-methyltransferase with sah
Structure: Guanidinoacetate n-methyltransferase. Chain: a, b, c, d. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gamt. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
1.86Å     R-factor:   0.228     R-free:   0.269
Authors: A.Dong,H.Wu,H.Zeng,P.Loppnau,M.Sundstrom,C.H.Arrowsmith,A.M. A.Bochkarev,A.N.Plotnikov,Structural Genomics Consortium (S
Key ref: A.Dong et al. The crystal structure of human guanidinoacetate n-Methyltransferase with sah. To be published, .
Date:
06-Jun-05     Release date:   14-Jun-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam  
Q14353  (GAMT_HUMAN) -  Guanidinoacetate N-methyltransferase
Seq:
Struc:
236 a.a.
229 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.1.1.2  - Guanidinoacetate N-methyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Creatine Biosynthesis
      Reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine
S-adenosyl-L-methionine
Bound ligand (Het Group name = SAH)
matches with 96.00% similarity
+ guanidinoacetate
= S-adenosyl-L-homocysteine
+ creatine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site