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Transferase PDB id
1zq9
Jmol
Contents
Protein chains
278 a.a. *
Ligands
SAM ×2
Waters ×809
* Residue conservation analysis
PDB id:
1zq9
Name: Transferase
Title: Crystal structure of human dimethyladenosine transferase
Structure: Probable dimethyladenosine transferase. Chain: a, b. Synonym: s- adenosylmethionine-6-n',n'-adenosylrrna, dimethyltransferase, 18s rrna dimethylase, hussy-05. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
1.90Å     R-factor:   0.165     R-free:   0.235
Authors: A.Dong,H.Wu,H.Zeng,P.Loppnau,M.Sundstrom,C.Arrowsmith, A.Edwards,A.Bochkarev,A.Plotnikov,Structural Genomics Consortium (Sgc)
Key ref: H.Wu et al. Crystal structure of human dimethyladenosine transferase with sam. To be published,
Date:
18-May-05     Release date:   31-May-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9UNQ2  (DIMT1_HUMAN) -  Probable dimethyladenosine transferase
Seq:
Struc: 		313 a.a.
278 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.2.1.1.183  - 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6- dimethyladenine1780 in 18S rRNA
4 × S-adenosyl-L-methionine
 + adenine(1779)/adenine(1780) in 18S rRNA
 = 4 × S-adenosyl-L-homocysteine
 + N(6)-dimethyladenine(1779)/N(6)- dimethyladenine(1780) in 18S rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   2 terms 
  Biological process     methylation   4 terms 
  Biochemical function     transferase activity     6 terms