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PDBsum entry 1zh9

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protein ligands metals links
Lyase PDB id
1zh9
Jmol
Contents
Protein chain
256 a.a. *
Ligands
MPX
BE7
Metals
_ZN
Waters ×239
* Residue conservation analysis
PDB id:
1zh9
Name: Lyase
Title: Carbonic anhydrase ii in complex with n-4-methyl-1- piperazinyl-n'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor
Structure: Carbonic anhydrase ii. Chain: a. Synonym: carbonate dehydratase ii, ca-ii, carbonic anhydrasE C. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.70Å     R-factor:   0.153     R-free:   0.212
Authors: V.S.Honndorf,A.Heine,G.Klebe,C.T.Supuran
Key ref: V.S.Honndorf et al. Carbonic anhydrase ii in complex with n-4-Methyl-1-Piperazinyl-N'-(P-Sulfonamide) phenylthiourea as sulfonamide inhibitor. To be published, .
Date:
23-Apr-05     Release date:   23-May-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
256 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zinc
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   10 terms 
  Biological process     angiotensin-mediated signaling pathway   20 terms 
  Biochemical function     protein binding     5 terms