PDBsum entry: 1zbu

Hydrolase

PDB id: 1zbu

Contents

Protein chains

225 a.a. *

304 a.a. *

Ligands

AMP ×4

Metals

_MG ×8

Waters ×37

* Residue conservation analysis

PDB id:

1zbu

Name:

Hydrolase

Title:

Crystal structure of full-length 3'-exonuclease

Structure:

3'-5' exonuclease eri1. Chain: a, b, c, d. Synonym: eri-1 homolog. Histone mRNA 3' end-specific exorib protein 3'hexo. Hexo. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eri1, 3'exo. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.00Å R-factor: 0.201 R-free: 0.225

Authors:

Y.Cheng,D.J.Patel

Key ref:

Y.Cheng and d.j.patel Structural basis for 3'-End specific recognition of histone mRNA stem-Loop by 3'-Exonuclease, A human nuclease that also targets sirna. To be published,

Date:

08-Apr-05 Release date: 19-Sep-06

Protein chains

Q8IV48  (ERI1_HUMAN) -  3'-5' exoribonuclease 1

Seq: 349 a.a.

Struc: 225 a.a.*

Protein chain

Q8IV48  (ERI1_HUMAN) -  3'-5' exoribonuclease 1

Seq: 349 a.a.

Struc: 304 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 

• Cellular component: histone pre-mRNA 3'end processing complex (5 terms)
• Biological process: histone mRNA catabolic process (4 terms)
• Biochemical function: histone pre-mRNA stem-loop binding (10 terms)